RSS-Feed abonnieren

DOI: 10.1055/s-0045-1810017
Three-Dimensional Finite-Element Study into the Effect of Scar Tissue on the Displacement of the Maxillary Segments by Rapid Palatal Expansion in Unilateral Cleft Lip, Alveolus, and Palate

Abstract
Objectives
Scar tissue tension may potentially influence the effectiveness of rapid palatal expansion (RPE) in patients with unilateral cleft lip and palate (UCLP). Comprehending the biomechanics of expansion appliances in individuals with UCLP is crucial in determining the suitable RPE design to rectify the asymmetric arch. This study used finite-element analysis (FEA) to investigate how scar contractures affect maxillary segments displacement during RPE in UCLP patients.
Materials and Methods
A three-dimensional model of the maxilla was constructed from cone beam computed tomography images of an 11-year-old boy with UCLP who received RPE. ANSYS 2022 R2 software was employed to conduct FEA simulations with this model. Three forces were considered: expansion force, upper lip tension, and scar tension. Two simulation conditions were analyzed: a control scenario with only the expansion force and a second scenario with all three forces applied. Displacement was assessed in transversal (x-axis), vertical (y-axis), and sagittal (z-axis) directions at 14 reference points located across the palate and dentition.
Results
Both simulations exhibited similar patterns of maxillary displacement, but the magnitude of displacement was reduced when scar and lip tension were included. The minor segment exhibited a greater displacement than the major segment, with the largest movement occurring in the anterior region along the x- and z-axes, which gradually decreased posteriorly. The displacement pattern was as follows: x-axis > z-axis > y-axis for the major segment and z-axis > x-axis > y-axis for the minor segment.
Conclusion
The FEA model demonstrated that RPE in UCLP produces an asymmetrical expansion with a pyramid-shaped displacement pattern. However, when scar tension from the palate and the upper lip is included, the extent of the segmental movement is reduced. These findings suggest that scar tissue tension may potentially influence the effectiveness of RPE in patients with UCLP.
Keywords
rapid palatal expander - finite-element analysis - scar - unilateral cleft lip and palate - medicineData Availability Statement
Derived data supporting the findings of this study are available from the corresponding author on request.
Ethical Approval
Ethical clearance was given by the ethics committee of the Faculty of Dentistry, UGM (No. 71/UN1/KEP/FKG-RSGM/EC/2023). Written informed consent was obtained from the patient's parents for CBCT data.
Publikationsverlauf
Artikel online veröffentlicht:
18. Juli 2025
© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)
Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India
-
References
- 1 Sumardi S, Latief BS, Kuijpers-Jagtman AM, Ongkosuwito EM, Bronkhorst EM, Kuijpers MAR. Long-term follow-up of mandibular dental arch changes in patients with complete non-syndromic unilateral cleft lip, alveolus, and palate. PeerJ 2021; 9: e12643
- 2 Kadir A, Mossey PA, Blencowe H. et al. Systematic review and meta-analysis of the birth prevalence of orofacial clefts in low- and middle-income countries. Cleft Palate Craniofac J 2017; 54 (05) 571-581
- 3 Meng WY, Ma YQ, Shi B, Liu RK, Wang XM. The comparison of biomechanical effects of the conventional and bone-borne palatal expanders on late adolescence with unilateral cleft palate: a 3-dimensional finite element analysis. BMC Oral Health 2022; 22 (01) 600
- 4 Kuijpers-Jagtman AM, Long RE. The influence of surgery and orthopedic treatment on maxillofacial growth and maxillary arch development in patients treated for orofacial clefts. Cleft Palate Craniofac J 2000; 37 (06) 1-12
- 5 Von Den Hoff JW, Maltha JC, Kuijpers-Jagtman AM. Palatal wound healing: the effects of scarring on growth. In: Berkowitz S. ed. Cleft Lip and Palate. Berlin: Springer; 2013: 309-324
- 6 Oberoi S, Hoffman WY, Chigurupati R, Vargervik K. Frequency of surgical correction for maxillary hypoplasia in cleft lip and palate. J Craniofac Surg 2012; 23 (06) 1665-1667
- 7 Richardson S, Krishna S, Khandeparker RV. A comprehensive management protocol to treat cleft maxillary hypoplasia. J Craniomaxillofac Surg 2018; 46 (02) 356-361
- 8 Iswati R, Farmasyanti CA, Ayub A, Kuijpers-Jagtman AM, Alhasyimi AA. Interdisciplinary management of class III malocclusion with cleft lip and palate. Dent J 2023; 56 (01) 7-12
- 9 Kuijpers-Jagtman AM, Kuijpers MAR. Cleft lip and palate: role of the orthodontist in the interdisciplinary management team. In: Krishnan V, Kuijpers-Jagtman AM. eds. Integrated Clinical Orthodontics. 2nd ed.. Hobroken, NJ: John Wiley & Sons Ltd; 2024: 128-149
- 10 Khdairi N, Halilah T, Khandakji M, Bartzela T. Rapid maxillary expansion treatment in patients with cleft lip and palate: a survey on clinical experience in the European cleft centers. J Clin Med 2023; 12 (09) 1-16
- 11 Biondi E, Bandini A, Lombardo L, Orlandi S, Siciliani G, Manfredi C. Phonetic analysis during treatment with rapid maxillary expander. Orthod Craniofac Res 2017; 20 (01) 21-29
- 12 Holberg C, Holberg N, Schwenzer K, Wichelhaus A, Rudzki-Janson I. Biomechanical analysis of maxillary expansion in CLP patients. Angle Orthod 2007; 77 (02) 280-287
- 13 Mathew A, Nagachandran KS, Vijayalakshmi D. Stress and displacement pattern evaluation using two different palatal expanders in unilateral cleft lip and palate: a three-dimensional finite element analysis. Prog Orthod 2016; 17 (01) 38
- 14 Al-Gunaid T, Asahito T, Yamaki M. et al. Relapse tendency in maxillary arch width in unilateral cleft lip and palate patients with different maxillary arch forms. Cleft Palate Craniofac J 2008; 45 (03) 278-283
- 15 Kim J, Uhm KI, Shin D, Lee J, Choi H. Maxillary distraction osteogenesis using a rigid external distractor: Which clinical factors are related with relapse?. J Craniofac Surg 2015; 26 (04) 1178-1181
- 16 Alhasyimi AA, Ayub A, Farmasyanti CA. Effectiveness of the attachment design and thickness of clear aligners during orthodontic anterior retraction: finite element analysis. Eur J Dent 2024; 18 (01) 174-181
- 17 Leeisaramas C, Chantarapanich N, Inglam S, Insee K. Analysis of stress distribution and displacement based on the miniscrew positions of the palatal slope bone-borne expander: a finite element study. Eur J Dent 2024; 18 (04) 1012-1021
- 18 Ateş EM, Pamukçu H, Koç O, Altıparmak N. Effects of different expansion appliances and surgical incisions on maxillary expansion: a finite element analysis. J Stomatol Oral Maxillofac Surg 2024; 125 (5S1): 101936
- 19 Marcin M, Katarzyna C. Stress and displacement patterns during orthodontic intervention in the maxilla of patients with cleft palate analyzed by finite element analysis: a systematic review. BMC Oral Health 2023; 23 (01) 93
- 20 Huang W, Li YH, Guo KL, Zhou YC, Li XJ. Finite element analysis of the comprehensive impact of scar and maxillary expansion combined with protraction on the development of maxilla with cleft lip and palate after repair operation. Hua Xi Kou Qiang Yi Xue Za Zhi 2020; 38 (06) 642-646
- 21 Carvalho Trojan L, Andrés González-Torres L, Claudia Moreira Melo A, Barbosa de Las Casas E. Stresses and strains analysis using different palatal expander appliances in upper jaw and midpalatal suture. Artif Organs 2017; 41 (06) E41-E51
- 22 Huang C, Akaishi S, Hyakusoku H, Ogawa R. Are keloid and hypertrophic scar different forms of the same disorder? A fibroproliferative skin disorder hypothesis based on keloid findings. Int Wound J 2014; 11 (05) 517-522
- 23 Trotman CA, Barlow SM, Faraway JJ. Functional outcomes of cleft lip surgery. Part III: measurement of lip forces. Cleft Palate Craniofac J 2007; 44 (06) 617-623
- 24 Matos GR, Neto RR, Júnior AJM, Junior RBB. Influence of the inclination of the incisal edge of planas direct tracks on deciduous dentition with anterior crossbite: finite-elements study. Eur J Dent 2022; 16 (03) 528-535
- 25 Işeri H, Tekkaya AE, Oztan O, Bilgiç S. Biomechanical effects of rapid maxillary expansion on the craniofacial skeleton, studied by the finite element method. Eur J Orthod 1998; 20 (04) 347-356
- 26 Xue R, Lai Q, Xing H. et al. Finite element analysis and clinical application of 3D-printed Ti alloy implant for the reconstruction of mandibular defects. BMC Oral Health 2024; 24 (01) 95
- 27 Pan X, Qian Y, Yu J, Wang D, Tang Y, Shen G. Biomechanical effects of rapid palatal expansion on the craniofacial skeleton with cleft palate: a three-dimensional finite element analysis. Cleft Palate Craniofac J 2007; 44 (02) 149-154
- 28 Agarwal A, Mathur R. Maxillary expansion. Int J Clin Pediatr Dent 2010; 3 (03) 139-146
- 29 Goeckner K, Pepakayala V, Nervina J, Gianchandani Y, Kapila S. Three-dimensional force measurements during rapid palatal expansion in Sus scrofa. Micromachines (Basel) 2016; 7 (04) 64
- 30 Lee H, Nguyen A, Hong C, Hoang P, Pham J, Ting K. Biomechanical effects of maxillary expansion on a patient with cleft palate: a finite element analysis. Am J Orthod Dentofacial Orthop 2016; 150 (02) 313-323
- 31 Garrett BJ, Caruso JM, Rungcharassaeng K, Farrage JR, Kim JS, Taylor GD. Skeletal effects to the maxilla after rapid maxillary expansion assessed with cone-beam computed tomography. Am J Orthod Dentofacial Orthop 2008; 134 (01) 8-9
- 32 Liu S, Xu T, Zou W. Effects of rapid maxillary expansion on the midpalatal suture: a systematic review. Eur J Orthod 2015; 37 (06) 651-655
- 33 Weissheimer A, de Menezes LME, Mezomo M, Dias DM, de Lima EMS, Rizzatto SMD. Immediate effects of rapid maxillary expansion with Haas-type and Hyrax-type expanders: a randomized clinical trial. Am J Orthod Dentofacial Orthop 2011; 140 (03) 366-376