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CC BY-NC-ND 4.0 · Indian J Radiol Imaging
DOI: 10.1055/s-0045-1810066
Original Article

Association of Pericardial Fat with Severity of Coronary Artery Disease

Sunil Kumar K. S.
1   Department of Radiodiagnosis, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India
,
Pankaj Sharma 
1   Department of Radiodiagnosis, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India
,
Barun Kumar
2   Department of Cardiology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India
,
Udit Chauhan
1   Department of Radiodiagnosis, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India
› Institutsangaben
Funding None.
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Abstract

Background

Obesity is a well-known risk factor for cardiovascular disease. Measurement of pericardial fat (PF) by multidetector computed tomography (MDCT) might have potential for early diagnosis and assessment of risk of coronary artery disease (CAD). Our study is the first study from India, wherein we have tried to find the association of PF with the severity of CAD.

Aim and Objective

To evaluate the association of PF quantified by MDCT with the severity of CAD.

Materials and Methods

This cross-sectional study was performed at a single-tertiary-care center over a period of 18 months, and included patients who referred for coronary computed tomography: (1) suspected case of CAD, (2) symptomatic patient with intermediate pretest probability of CAD, or uninterpretable electrocardiogram, or unable to exercise on stress test. Periprostatic fat volume (PFV) was quantified using semiautomated technique, for measuring the amount of fat during end-systolic phase. Patients who had evidence of CAD were considered “CAD positive” in this study.

Observation and Results

A total of 87 patients were enrolled in this study. However, 7 patients were excluded due to motion artifacts and 80 patients (females, 27.5%, and males, 72.5%; mean age, 49.30 ± 12.27 years) were eligible for this study. PFV ranged from 28 to 547 mL, and the median value of PFV was around 100 mL.

Conclusion

Our study demonstrated a significant association between PF and age/body mass index/risk factors such as diabetes or family history. Higher PF was strongly associated with calcium score and severity of stenosis on computed tomography coronary angiography. Thus, PF is a risk predictor in subclinical CAD patients.

Keywords

pericardial fat volume - epicardial fat volume - coronary artery disease - multidetector computer tomography - coronary angiography - coronary artery calcium score

Ethical Approval

Ethical approval was obtained from the Institutional Ethics Committee. We obtained informed consent from every patient. The study conforms to the Ethical Guidelines of the Declaration of Helsinki.


Patients' Consent

Written informed consent to publish the personal and clinical details of the participant was obtained from patients.




Publikationsverlauf

Artikel online veröffentlicht:
18. Juli 2025

© 2025. Indian Radiological Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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