Open Access
CC BY 4.0 · Arq Neuropsiquiatr 2025; 83(08): s00451810408
DOI: 10.1055/s-0045-1810408
Review Article

The cerebellum and psychiatric disorders: unraveling its role in mental health

1   Universidade Federal do Ceará, Faculdade de Medicina, Departamento de Clínica Médica, Seção de Neurologia, Fortaleza CE, Brazil.
2   Universidade do Estado do Ceará, Centro de Ciências da Saúde, Fortaleza CE, Brazil.
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1   Universidade Federal do Ceará, Faculdade de Medicina, Departamento de Clínica Médica, Seção de Neurologia, Fortaleza CE, Brazil.
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1   Universidade Federal do Ceará, Faculdade de Medicina, Departamento de Clínica Médica, Seção de Neurologia, Fortaleza CE, Brazil.
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3   University Health Network, Toronto Western Hospital, Morton and Gloria Shulman Movement Disorders Centre and the Edmond J. Safra Program in Parkinson's Disease, Toronto ON, Canada.
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4   Universidade Federal de São Paulo, Escola Paulista de Medicina, Departamento de Neurologia e Neurocirurgia, Unidade de Ataxia, São Paulo SP, Brazil.
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4   Universidade Federal de São Paulo, Escola Paulista de Medicina, Departamento de Neurologia e Neurocirurgia, Unidade de Ataxia, São Paulo SP, Brazil.
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4   Universidade Federal de São Paulo, Escola Paulista de Medicina, Departamento de Neurologia e Neurocirurgia, Unidade de Ataxia, São Paulo SP, Brazil.
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Abstract

Several studies describe a strong association between structural and functional abnormalities of the cerebellum and psychiatric disorders. It is possible to find investigations especially in cases of schizophrenia, bipolar disorder, depression, anxiety disorders, attention-deficit/hyperactivity disorder (ADHD), and autism spectrum disorder (ASD). The involvement of the cerebellum in these conditions is also supported by clinical, functional, and structural imaging studies. The present narrative review aims to discuss and highlight the role of the cerebellum in these disorders, gathering evidence on the possible locations and connections of the affected cerebellar areas and their implications in the cognitive, emotional, and behavioral domains.

Authors' Contributions

Formal analysis: PBN, MWBS, SSOS, RPM, LENF, JLP, OGPB; Writing – original draft: PBN, MWBS, SSOS, RPM, LENF, JLP, OGPB; Writing – review & editing: PBN, MWBS, SSOS, RPM, LENF, JLP, OGPB.


Data Availability Statement

The datasets generated and/or analyzed during the current study are available from the corresponding author upon reasonable request.


Editor-in-Chief: Hélio A. G. Teive (https://orcid.org/0000-0003-2305-1073).


Associate Editor: Antonio Lucio Teixeira (https://orcid.org/0000-0002-9621-5422).




Publikationsverlauf

Eingereicht: 06. März 2025

Angenommen: 19. Mai 2025

Artikel online veröffentlicht:
31. August 2025

© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit (https://creativecommons.org/licenses/by/4.0/)

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Bibliographical Record
Pedro Braga-Neto, Maria Wanessa Barbosa dos Santos, Stephanie Suzanne de Oliveira Scott, Renato Puppi Munhoz, Luiz Eduardo Novis, José Luiz Pedroso, Orlando Graziani Povoas Barsottini. The cerebellum and psychiatric disorders: unraveling its role in mental health. Arq Neuropsiquiatr 2025; 83: s00451810408.
DOI: 10.1055/s-0045-1810408