Z Gastroenterol 2025; 63(08): e635-e636
DOI: 10.1055/s-0045-1811131
Abstracts | DGVS/DGAV
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CEUS-guided biopsies in soft tissue tumors

Authors

  • A-C Zygmunt

    1   Universitätsmedizin Göttingen, Klinik für Allgemein-, Viszeral- und Kinderchirurgie, Göttingen, Deutschland

  • E Yilmaz

    1   Universitätsmedizin Göttingen, Klinik für Allgemein-, Viszeral- und Kinderchirurgie, Göttingen, Deutschland

  • M Nietert

    2   Universitätsmedizin Göttingen, Institut für medizinische Biostatistik, Göttingen, Deutschland

  • A Seif

    3   Universitätsmedizin Göttingen, Institut für Klinische und Interventionelle Radiologie, Göttingen, Deutschland

  • S Philipp

    4   Universitätsmedizin Göttingen, Institut für Pathologie, Göttingen, Deutschland

  • M Lerchbaumer

    5   Charite, Universitätsmedizin Berlin, Klinik für Radiologie, Berlin, Deutschland

  • M Ghadimi

    1   Universitätsmedizin Göttingen, Klinik für Allgemein-, Viszeral- und Kinderchirurgie, Göttingen, Deutschland

  • F Bösch

    1   Universitätsmedizin Göttingen, Klinik für Allgemein-, Viszeral- und Kinderchirurgie, Göttingen, Deutschland

  • Y-JP Jo

    1   Universitätsmedizin Göttingen, Klinik für Allgemein-, Viszeral- und Kinderchirurgie, Göttingen, Deutschland
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Introduction: In patients with soft tissue tumors (STT), treatment planning depends on tumor entity. Core needle biopsy (CNB) is the diagnostic standard. Contrast-enhanced ultrasonography (CEUS) has provided promising results but is still not widely used in the evaluation of STT, especially when located in the retroperitoneum. The purpose of this study was to evaluate the role of CEUS in diagnosing STT.

Methods: This is a retrospective study of 69 Patients (35 male, 34 female) subjected to CEUS-guided CNB, treated from Dec 2021 to July 2024 at the Sarcoma Center of the University Medical Center Goettingen. US and CEUS were performed with the Logiq S8 XDClear (GE, USA) and using sulfur hexafluoride microbubbles (SonoVue, Bracco, Italy) as contrast medium. Adequate probes with sufficient and probable diagnosis were analysed for accuracy in differentiating between malignant and benign, furthermore however diagnosing subtype and grading.

The masses biopsied were located in the abdomen and retroperitoneum (n=15), trunk (including shoulder, neck, hip, glutes) (n=22), upper (n=3) and lower extremities (n=26) as well as groin (n=3).

Results: The patients’ age ranged from 22 to 86 years at time of biopsy. Out of 69 STS, adequate samples were retrieved through CEUS-guided biopsy in 64 (28 benign, 36 malignant) cases (92,75%). 46 cases could be compared histopathologically to resected specimen. After adequate CEUS-CNB-sampling and comparison to resected specimen (42 cases=91,3%), our results showed no false positives or negatives regarding differentiation between malignant and benign masses; sensitivity and specificity were 100%. PPV as well as NPV were also 100%. Considering histopathological subtypes, 41/42 yielded correct histopathological subtype (97,6%). In malignant masses, 18/22 diagnosis were concordant in initial and definitive grading (81%). No peri- or postinterventional complications occurred.

Conclusion: CEUS-guided CNB is safe and has proven to be a promising method in guiding biopticsampling of STT, directing the needle to the most significant areas of the tumor. The need for re-biopsy is low and can safely be conducted, if necessary, while concordance in histopathological diagnosis of biopsy and resection sample is extremely high. This allows for precise diagnosis and optimised neoadjuvant treatment for patients.



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Artikel online veröffentlicht:
04. September 2025

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