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DOI: 10.1055/s-0045-1811169
A Comparative Analysis of Clinical Outcomes between Proximal and Distal Recipient Vessel Microanastomosis for Lower Limb Reconstruction
Authors

Abstract
Background
This study aims to compare the clinical outcomes of lower limb free-flap reconstruction with vascular anastomosis performed proximal versus distal to the zone of injury. Very few comparative studies on this topic have been published to date. These studies are discussed in this article.
Materials and Methods
A retrospective analysis of microvascular free-flap reconstructions for lower extremity defects over a 5-year period, from 2018 to 2023, was conducted. Outcomes of vascular anastomosis distal to the zone of injury were compared with those proximal to the zone of injury. Clinical parameters evaluated included flap failure, arterial and venous compromise, operative takebacks, and their success rates.
Results
Of the 101 cases included in our analysis, 81 underwent vascular anastomosis proximal to the zone of injury, and 20 underwent distal anastomosis. In total, 72 (88.88%) proximal and 18 (90%) distal anastomoses were successful. Arterial thrombus occurred in 1 case (5%) among those who underwent distal anastomosis and in 4 cases (4.9%) of the proximal anastomosis cohort, whereas venous thrombus was seen in 1 case (5%) of the distal group and 12 cases (14.81%) of the proximal group. No statistically significant differences were found in clinical outcomes between the groups.
Conclusion
Free tissue transfer using recipient vessels distal to the zone of injury is a reliable option for lower limb reconstruction. Distal anastomosis, which can be technically less challenging, demonstrates survival rates comparable to proximal anastomosis and can be considered a viable approach in selected patients.
Patients' Consent
Informed consent was obtained from all the participants of the study.
Publication History
Article published online:
25 September 2025
© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)
Thieme Medical and Scientific Publishers Pvt. Ltd.
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References
- 1 Mundy LR, Truong T, Shammas RL, Gage MJ, Pomann GM, Hollenbeck ST. Acute treatment patterns for lower extremity trauma in the United States: flaps versus amputation. J Reconstr Microsurg 2017; 33 (08) 563-570
- 2 Hammert WC, Minarchek J, Trzeciak MA. Free-flap reconstruction of traumatic lower extremity wounds. Am J Orthop 2000; 29 (9, Suppl): 22-26
- 3 Acland RD. Refinements in lower extremity free flap surgery. Clin Plast Surg 1990; 17 (04) 733-744
- 4 Kolker AR, Kasabian AK, Karp NS, Gottlieb JJ. Fate of free flap microanastomosis distal to the zone of injury in lower extremity trauma. Plast Reconstr Surg 1997; 99 (04) 1068-1073
- 5 Stompro BE, Stevenson TR. Reconstruction of the traumatized leg: use of distally based free flaps. Plast Reconstr Surg 1994; 93 (05) 1021-1025 , discussion 1026–1027
- 6 Mathes SJ. Discussion-reconstruction of the traumatized leg: use of distally based free flaps. Plast Reconstr Surg 1994; 93 (05) 1026-1027
- 7 Godina M. Early microsurgical reconstruction of complex trauma of the extremities. Plast Reconstr Surg 1986; 78 (03) 285-292
- 8 Harashina T. Analysis of 200 free flaps. Br J Plast Surg 1988; 41 (01) 33-36
- 9 Khouri RK, Shaw WW. Reconstruction of the lower extremity with microvascular free flaps: a 10-year experience with 304 consecutive cases. J Trauma 1989; 29 (08) 1086-1094
- 10 Loos MS, Freeman BG, Lorenzetti A. Zone of injury: a critical review of the literature. Ann Plast Surg 2010; 65 (06) 573-577
- 11 Godina M, Arnez ZM, Lister GD. Preferential use of the posterior approach to blood vessels of the lower leg in microvascular surgery. Plast Reconstr Surg 1991; 88 (02) 287-291
- 12 Isenberg JS, Sherman R. Zone of injury: a valid concept in microvascular reconstruction of the traumatized lower limb?. Ann Plast Surg 1996; 36 (03) 270-272
- 13 Spector JA, Levine S, Levine JP. Free tissue transfer to the lower extremity distal to the zone of injury: indications and outcomes over a 25-year experience. Plast Reconstr Surg 2007; 120 (04) 952-959
- 14 Park S, Han SH, Lee TJ. Algorithm for recipient vessel selection in free tissue transfer to the lower extremity. Plast Reconstr Surg 1999; 103 (07) 1937-1948
- 15 Stranix JT, Borab ZM, Rifkin WJ. et al. Proximal versus distal recipient vessels in lower extremity reconstruction: a retrospective series and systematic review. J Reconstr Microsurg 2018; 34 (05) 334-340
- 16 Stranix JT, Lee ZH, Jacoby A. et al. Not all Gustilo type IIIB fractures are created equal: arterial injury impacts limb salvage outcomes. Plast Reconstr Surg 2017; 140 (05) 1033-1041
- 17 Yazar S, Lin CH, Wei FC. One-stage reconstruction of composite bone and soft-tissue defects in traumatic lower extremities. Plast Reconstr Surg 2004; 114 (06) 1457-1466
- 18 Bendon CL, Giele HP. Success of free flap anastomoses performed within the zone of trauma in acute lower limb reconstruction. J Plast Reconstr Aesthet Surg 2016; 69 (07) 888-893
- 19 Hallock GG. Liability of recipient vessels distal to the zone of injury when used for extremity free flaps. J Reconstr Microsurg 1996; 12 (02) 89-92
- 20 Heller L, Levin LS. Lower extremity microsurgical reconstruction. Plast Reconstr Surg 2001; 108 (04) 1029-1041 , quiz 1042
- 21 Yazar S, Lin CH. Selection of recipient vessel in traumatic lower extremity. J Reconstr Microsurg 2012; 28 (03) 199-204
- 22 Hong JP, Koshima I. Using perforators as recipient vessels (supermicrosurgery) for free flap reconstruction of the knee region. Ann Plast Surg 2010; 64 (03) 291-293
- 23 Fang T, Zhang EW, Lineaweaver WC, Zhang F. Recipient vessels in the free flap reconstruction around the knee. Ann Plast Surg 2013; 71 (04) 429-433
- 24 Hong JP, Park CJ, Suh HP. Importance of vascularity and selecting the recipient vessels of lower extremity reconstruction. J Reconstr Microsurg 2021; 37 (01) 83-88
- 25 Othman S, Stranix JT, Piwnica-Worms W. et al. Microvascular free tissue transfer for reconstruction of complex lower extremity trauma: Predictors of complications and flap failure. Microsurgery 2023; 43 (01) 5-12
- 26 Terry PH, Burke JF, Demers AJ, Moran TE, Weiss DB, Stranix JT. Arterial injury in tibial fracture correlates with trauma severity and orthopaedic outcomes. Orthoplastic Surg 2022; 7: 25-30
- 27 Zeiderman MR, Bailey CM, Arora A, Pu LLQ. Anterior tibial vessel turnover as recipient vessel for complex free tissue transfer around the knee. J Plast Reconstr Aesthet Surg 2020; 73 (10) 1897-1916
- 28 Stranix JT, Lee ZH, Jacoby A. et al. Forty years of lower extremity take-backs: flap type influences salvage outcomes. Plast Reconstr Surg 2018; 141 (05) 1282-1287
- 29 Minami A, Kato H, Suenaga N, Iwasaki N. Distally-based free vascularized tissue grafts in the lower leg. J Reconstr Microsurg 1999; 15 (07) 495-499