Open Access
CC BY 4.0 · Indian J Med Paediatr Oncol
DOI: 10.1055/s-0045-1811249
Review Article

Navigating the Genetic Frontier: Establishing Genetic Clinics for Comprehensive Hereditary Cancer Management in Resource-Limited Settings

1   Department of Medical Oncology, Homi Bhabha Cancer Hospital and Mahamana Pandit Madan Mohan Malaviya Cancer Centre, Tata Memorial Centre, Homi Bhabha National Institute, Varanasi, Uttar Pradesh, India
,
Ankita Rungta Kapoor
2   Department of Radiation Oncology, Homi Bhabha Cancer Hospital and Mahamana Pandit Madan Mohan Malaviya Cancer Centre, Tata Memorial Centre, Homi Bhabha National Institute, Varanasi, Uttar Pradesh, India
,
Archi Rungta
3   Department of Cancer Genetics, Tata Memorial Hospital, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, Maharashtra, India
,
1   Department of Medical Oncology, Homi Bhabha Cancer Hospital and Mahamana Pandit Madan Mohan Malaviya Cancer Centre, Tata Memorial Centre, Homi Bhabha National Institute, Varanasi, Uttar Pradesh, India
,
Anuj Gupta
1   Department of Medical Oncology, Homi Bhabha Cancer Hospital and Mahamana Pandit Madan Mohan Malaviya Cancer Centre, Tata Memorial Centre, Homi Bhabha National Institute, Varanasi, Uttar Pradesh, India
,
Bipinesh Sansar
1   Department of Medical Oncology, Homi Bhabha Cancer Hospital and Mahamana Pandit Madan Mohan Malaviya Cancer Centre, Tata Memorial Centre, Homi Bhabha National Institute, Varanasi, Uttar Pradesh, India
,
Amit Kumar
4   Department of Medical Oncology, Homi Bhabha Cancer Hospital and Research Centre, Tata Memorial Centre, Homi Bhabha National Institute, Muzaffarpur, Bihar, India
,
5   Department of Pathology, Homi Bhabha Cancer Hospital and Mahamana Pandit Madan Mohan Malaviya Cancer Centre, Tata Memorial Centre, Homi Bhabha National Institute, Varanasi, Uttar Pradesh, India
,
Shashikant Patne
5   Department of Pathology, Homi Bhabha Cancer Hospital and Mahamana Pandit Madan Mohan Malaviya Cancer Centre, Tata Memorial Centre, Homi Bhabha National Institute, Varanasi, Uttar Pradesh, India
,
Satyajit Pradhan
2   Department of Radiation Oncology, Homi Bhabha Cancer Hospital and Mahamana Pandit Madan Mohan Malaviya Cancer Centre, Tata Memorial Centre, Homi Bhabha National Institute, Varanasi, Uttar Pradesh, India
,
6   Radiation Oncology, Tata Memorial Hospital, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, Maharashtra, India
› Author Affiliations

Funding None.
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Abstract

This review article explores the vital role of genetic clinics in the management of hereditary cancers, emphasizing their significance in early detection, tailored treatment, and family screening. It presents analysis of the prevalence of hereditary cancers in India, including breast, ovarian, prostate, colon, and kidney cancers, stressing the necessity for effective genetic testing and counseling services.

The manuscript synthesizes available prevalence data, outlines key components and challenges of clinic establishment, and provides strategies for improving public acceptance, access, and workforce capacity. It also focuses on importance of early detection, family screening, and targeted therapies for patients with inherited genetic mutation.

In conclusion, the article emphasizes the need for a patient-centered approach, increased access to genetic clinics, exploration of future genomics and technology advancements, and the evaluation of genetic clinics' impact on patient outcomes. By addressing challenges and capitalizing on opportunities, genetic clinics can continue to improve patients' and their families' lives, ultimately contributing to the battle against hereditary cancers.

Data Availability Statement

Data sharing is not applicable to this article as no new data were created or analyzed in this study


Patient Consent

No patient data was collected as informed consent was not required.




Publication History

Article published online:
22 August 2025

© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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