RSS-Feed abonnieren
PDF herunterladen
DOI: 10.1055/s-0045-1811529
Infrared Thermography – A Novel Tool in the Surgical Treatment of H3 K27M-Altered Diffuse Midline Spinal Cord Glioma: Technical and Case Report
Authors
Abstract
Diffuse midline gliomas (DMGs), H3K27-altered, are rare and aggressive tumors primarily affecting children, though adult cases occur. These gliomas present significant surgical challenges, and novel techniques are needed to improve outcomes. We present the case of a 53-year-old male with a solid expansive lesion located at T12 to L1, who presented with bilateral thigh pain, loss of sphincter control, and increased urinary frequency. Initial magnetic resonance imaging suggested an ependymoma; however, tumor resection followed by immunohistochemical analysis confirmed a diagnosis of diffuse midline glioma, H3K27-altered. The patient underwent a successful two-level lumbar laminectomy with a microsurgical gross total resection. An innovative technique of intraoperative infrared thermography mapping was employed, representing a novel approach for this rare tumor. The patient remains alive at the time of the present publication.
Authors' Contributions
GFSQ: conceptualization, data curation, formal analysis, funding acquisition, investigation, methodology, project administration, resources, software, supervision, validation, visualization, writing – original draft, writing – review & editing; BMD, AACD, CCMPC, DMS, AASS, LSO: data curation, investigation, methodology, writing – review & editing; LRS, MMF, LAWH: supervision, validation, resources.
Publikationsverlauf
Eingereicht: 15. Oktober 2024
Angenommen: 27. Juni 2025
Artikel online veröffentlicht:
14. September 2025
© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit (https://creativecommons.org/licenses/by/4.0/)
Thieme Revinter Publicações Ltda.
Rua Rego Freitas, 175, loja 1, República, São Paulo, SP, CEP 01220-010, Brazil
Gabriel Filipe Soares Quiuqui, Bárbara Moreira Diniz, Antonio Augusto de Carvalho Duarte, Caio Cesar Martins Pedrosa de Castro, Daniel Mendes de Souza, Artiel Aurino Sousa Sampaio, Lucas Scharf Oliveira, Lucas Rodrigues de Souza, Marcelo Mamede de Freitas, Leonardo Augusto Wendling Henriques. Infrared Thermography – A Novel Tool in the Surgical Treatment of H3 K27M-Altered Diffuse Midline Spinal Cord Glioma: Technical and Case Report. Brazilian Journal of Oncology 2025; 21: s00451811529.
DOI: 10.1055/s-0045-1811529
-
References
- 1
Zhao JP,
Liu XJ,
Lin HZ,
Cui CX,
Yue YJ,
Gao S.
et al.
MRI comparative study of diffuse midline glioma, H3 K27-altered and glioma in the
midline without H3 K27-altered. BMC Neurol 2022; 22 (01) 498
Reference Ris Wihthout Link
- 2
Qiu T,
Chanchotisatien A,
Qin Z,
Wu J,
Du Z,
Zhang X.
et al.
Imaging characteristics of adult H3 K27M-mutant gliomas. J Neurosurg 2019; 133 (06)
1662-1670
Reference Ris Wihthout Link
- 3
Schulte JD,
Buerki RA,
Lapointe S,
Molinaro AM,
Zhang Y,
Villanueva-Meyer JE.
et al.
Clinical, radiologic, and genetic characteristics of histone H3 K27M-mutant diffuse
midline gliomas in adults. Neurooncol Adv 2020; 2 (01) vdaa142
Reference Ris Wihthout Link
- 4
Naydenov E,
Minkin K,
Penkov M,
Nachev S,
Stummer W.
Infrared Thermography in Surgery of Newly Diagnosed Glioblastoma Multiforme: A Technical
Case Report. Case Rep Oncol 2017; 10 (01) 350-355
Reference Ris Wihthout Link
- 5
Menezes DR,
de Lima L,
Mansilla R,
Conci A,
Rueda F,
Velarde LGC.
et al.
A prospective study on the usefulness of high-resolution intraoperative infrared thermography
in intracranial tumors. Front Surg 2024; 11: 1386722
Reference Ris Wihthout Link