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CC BY 4.0 · Indian J Med Paediatr Oncol
DOI: 10.1055/s-0045-1811554
Case Series

Clinical Insights into Duodenal Neuroendocrine Tumors: A Case Series

Debasmita Pal 
1   Department of Medical Oncology, K.S. Hegde Medical Academy of NITTE (Deemed to be University), Mangalore, Karnataka, India
,
Adesh Kumar 
1   Department of Medical Oncology, K.S. Hegde Medical Academy of NITTE (Deemed to be University), Mangalore, Karnataka, India
,
Vijith Shetty
1   Department of Medical Oncology, K.S. Hegde Medical Academy of NITTE (Deemed to be University), Mangalore, Karnataka, India
,
Kishan Prasad HL
2   Department of Pathology, K.S. Hegde Medical Academy of NITTE (Deemed to be University), Mangalore, Karnataka, India
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Funding None.
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Abstract

Duodenal neuroendocrine tumors (d-NETs) are rare neoplasms representing a small subset of gastrointestinal NETs. Due to their nonspecific symptoms, such as abdominal pain, vomiting, and weight loss, diagnosis is often delayed. This case series analyzes six patients with well-differentiated d-NETs, highlighting their clinical presentation, diagnostic evaluation, treatment strategies, and follow-up. Diagnosis was established through endoscopic biopsy, imaging modalities including computed tomography (CT) and positron emission tomography-CT, and confirmed by histopathology and immunohistochemistry. Tumors were graded using the World Health Organization/European Neuroendocrine Tumor Society classification, with Ki-67 indices ranging from 1 to 6%, corresponding to grade 1 or 2 NETs. Treatment included endoscopic or surgical resection in localized cases, while somatostatin analog therapy and peptide receptor radionuclide therapy were used in multifocal or metastatic disease. All patients were managed with an individualized, multidisciplinary approach, and demonstrated stable disease on follow-up. This study emphasizes the importance of early detection, accurate grading, and personalized management to optimize outcomes in patients with d-NETs.

Keywords

case series - duodenal neuroendocrine tumors - diagnosis - octreotide therapy - surgical resection

Authors' Contributions

V.S., K.P.H.L.: Concepts. D.P., A.K.: Design; D.P., V.S., K.P.H.L.: Definition of intellectual content; D.P.: Literature search; D.P., A.K., V.S.: Clinical studies; A.K., K.P.H.L.: Data analysis; D.P., K.P.H.L.: Manuscript preparation; A.K.: Manuscript editing; D.P., A.K., V.S., K.P.H.L.: Manuscript review; A.K.: Guarantor.


Ethical Approval

Institutional ethical committee approval was obtained.


Patient's Consent

Informed consent was obtained from the patient or the patient's party for the publication of the cases. No patient information was used without consent. The identity of the patients and the patient party has been kept confidential.




Publikationsverlauf

Artikel online veröffentlicht:
26. August 2025

© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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