Cerebellar and extra-cerebellar symptoms in movement disorders

Abstract

The cerebellum and basal ganglia are integrated structures of the motor system, classically viewed as separate entities with different roles. Interactions between these structures were believed to occur mainly at the cortical level. However, neuroanatomical studies have resulted in a shift in this perspective. Symptoms attributed to basal ganglia disorders may arise from aberrant cerebellar circuit activity, and, conversely, cerebellar dysfunction may manifest due to pathological changes in basal ganglia pathways. In this narrative review, we present multiple disorders of the basal ganglia and cerebellum, highlighting their intricate interactions.

Keywords

Cerebellum - Basal Ganglia - Movement Disorders - Ataxia

Authors' Contributions

Conceptualization: JLP; Data curation: DLB, VRP; Formal analysis: DLB, VRP; Funding acquisition: JLP; Investigation: DLB, VRP; Methodology: DLB, VRP; Project administration: JLP; Resources: JLP; Software: JLP; Supervision: JLP; Validation: JLP; Visualization: HBF, OGPB; Writing – original draft: DLB, VRP Writing – review & editing: HBF, OGPB.

Data Availability Statement

No new data were generated or analyzed in this study.

Editor-in-Chief: Hélio A. G. Teive https://orcid.org/0000-0003-2305-1073.

Associate Editor: Vitor Tumas https://orcid.org/0000-0003-2402-2709.

Publikationsverlauf

Eingereicht: 30. März 2025

Angenommen: 15. Juli 2025

Artikel online veröffentlicht:
19. September 2025

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