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CC BY 4.0 · Indian J Med Paediatr Oncol
DOI: 10.1055/s-0045-1812068
Original Article

A Retrospective Multicenter Real-World Study to Determine the Efficacy and Safety of PHESGO in HER2-Positive Breast Cancer from a Community Oncology Practice in Western India

Authors

  • Udip Maheshwari

    1   Department of Medical Oncology, MOC Cancer Care & Research Centre, Mumbai, Maharashtra, India

  • Vashishth Maniar

    1   Department of Medical Oncology, MOC Cancer Care & Research Centre, Mumbai, Maharashtra, India

  • Ashish Joshi

    1   Department of Medical Oncology, MOC Cancer Care & Research Centre, Mumbai, Maharashtra, India

  • Pritam Kalaskar

    1   Department of Medical Oncology, MOC Cancer Care & Research Centre, Mumbai, Maharashtra, India

  • Kshitij Joshi

    1   Department of Medical Oncology, MOC Cancer Care & Research Centre, Mumbai, Maharashtra, India

  • Disha Morzaria 

    4   Department of Clinical Research, MOC Cancer Care & Research Centre, Mumbai, Maharashtra, India

  • Pradip Kendre

    1   Department of Medical Oncology, MOC Cancer Care & Research Centre, Mumbai, Maharashtra, India

  • Smit Sheth

    1   Department of Medical Oncology, MOC Cancer Care & Research Centre, Mumbai, Maharashtra, India

  • Chandrashekhar Pethe

    2   Department of Medical Oncology, MOC Cancer Care & Research Centre, Nashik, Maharashtra, India

  • Sonal Dhande

    2   Department of Medical Oncology, MOC Cancer Care & Research Centre, Nashik, Maharashtra, India

  • Seema Jagiasi

    1   Department of Medical Oncology, MOC Cancer Care & Research Centre, Mumbai, Maharashtra, India

  • Taha Sethjiwala

    3   Department of Medical Oncology, MOC Cancer Care & Research Centre, Indore, Madhya Pradesh, India

  • Krushna Chaudhari

    3   Department of Medical Oncology, MOC Cancer Care & Research Centre, Indore, Madhya Pradesh, India

Funding None.
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Abstract

Introduction

The treatment landscape for HER2-positive breast cancer has evolved with the introduction of targeted therapy using trastuzumab and pertuzumab. Though effective, intravenous (IV) administration presents challenges like infusion-related reactions and logistical issues, affecting patient adherence and quality of life. The advent of the subcutaneous (SC) formulation of PHESGO has emerged as a promising alternative, which enhances patient experience and adherence in the treatment of HER2-positive breast cancer.

Objectives

This study evaluates the efficacy, safety, and patient preference of PHESGO in a real-world setting.

Materials and Methods

This retrospective analysis included 30 patients with HER2-positive breast cancer receiving PHESGO as monotherapy or in combination with chemotherapy. Inclusion criteria encompassed patients aged 18 to 80 with comprehensive medical records and documented survival status. Data were extracted from electronic medical records to evaluate treatment efficacy, adverse events, and patient satisfaction, using validated Patient Preference and Therapeutic Antibody Satisfaction Questionnaire - Subcutaneous Injection (TASQ-SC) questionnaires.

Results

The median (interquartile range) age was 53.5 (18.0) years, with most patients at cancer stage IV (36.7%). PHESGO achieved an 86.7% objective response rate (ORR) and 76.7% [95% CI: 59.07–88.21] progression-free survival over a median survival duration of 496 days. Nearly 90% of the patients remained alive at the end of the observation period. Among neoadjuvant chemotherapy patients, a 75.0% pathological complete response rate was observed. All participants (100%) preferred SC administration, citing greater comfort and reduced clinic time, with 89.5% reporting minimal pain.

Conclusion

The findings indicate comparable efficacy and a favorable safety profile of PHESGO relative to traditional IV administration. The high levels of satisfaction and preference for SC administration suggest that PHESGO not only meets clinical efficacy standards but also meaningfully enhances the overall patient experience.

Keywords

breast neoplasms - trastuzumab - pertuzumab - drug administration routes - patient preference

Patients' Consent

Written informed consent was obtained from all participants before their inclusion in the study.


Supplementary Material



Publikationsverlauf

Artikel online veröffentlicht:
09. Oktober 2025

© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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