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CC BY 4.0 · Brazilian Journal of Oncology 2025; 21: s00451812295
DOI: 10.1055/s-0045-1812295
Case Report
Radiotherapy

The Potential of Hypofractionated Radiotherapy: A Revolutionary Treatment for Anorectal Malignant Melanomas

Authors

  • Vandana Thakur 

    1   Department of Radiotherapy & Oncology, Dr. Rajendra Prasad Government Medical College (DR. RPGMC), Tanda, Kangra, Himachal Pradesh, India

  • Poorva Vias 

    1   Department of Radiotherapy & Oncology, Dr. Rajendra Prasad Government Medical College (DR. RPGMC), Tanda, Kangra, Himachal Pradesh, India

  • Hardik Sharma 

    2   Department of Radiotherapy & Oncology, Postgraduate Institute of Medical Education & Research (PGIMER), Chandigarh, India

  • Pratibha Prashar

    1   Department of Radiotherapy & Oncology, Dr. Rajendra Prasad Government Medical College (DR. RPGMC), Tanda, Kangra, Himachal Pradesh, India

  • Aditya Jamwal

    3   Department of Pathology, Dr. Rajendra Prasad Government Medical College (DR. RPGMC), Tanda, Kangra, Himachal Pradesh, India

  • Anupam Thakur

    4   Department of Pathology, Postgraduate Institute of Medical Education & Research (PGIMER), Chandigarh, India
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Abstract

Mucosal melanomas generally arise from mucosal epithelium lining the respiratory, alimentary, and genitourinary tracts and usually carry worse prognosis than cutaneous melanomas. Anorectal melanomas account for 50% of gastrointestinal tract melanomas and 0.3 to 1% of all malignant melanomas. There are no specific treatment guidelines due to the scarcity of the disease, its unique biology, and challenges in management owing to the anatomic location. We report a case of anorectal malignant melanoma treated successfully with abdominoperineal resection followed by hypofractionated radiotherapy in a setting where financial toxicity limits treatment options. The patient presents complete response 2 years postdiagnosis, emphasizing that radiation therapy can be utilized for more than just palliation.

Keywords

malignant melanoma - hypofractionated radiotherapy - anorectal melanoma

Authors' Contributions

VT: data collection, data curation, data analysis and interpretation, writing – original draft, accountability for all aspects of the work; PP: provision of study material and patient care; HS: writing – original draft, critical review and editing of the manuscript; AT: writing – review & editing; AJ: conception and design; PV: final approval of the manuscript.


Informed Consent

Informed consent was obtained from all patients included in the study.




Publication History

Received: 19 March 2025

Accepted: 25 July 2025

Article published online:
27 October 2025

© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit (https://creativecommons.org/licenses/by/4.0/)

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Bibliographical Record
Vandana Thakur, Poorva Vias, Hardik Sharma, Pratibha Prashar, Aditya Jamwal, Anupam Thakur. The Potential of Hypofractionated Radiotherapy: A Revolutionary Treatment for Anorectal Malignant Melanomas. Brazilian Journal of Oncology 2025; 21: s00451812295.
DOI: 10.1055/s-0045-1812295
 

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