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CC BY 4.0 · World J Nucl Med
DOI: 10.1055/s-0045-1813680
Case Report

Amyloid Mimicking Myeloma: A Diagnostic Trap

Authors

  • Shivangi Dikshit 

    1   Department of Nuclear Medicine, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India

  • Sukanta Barai

    1   Department of Nuclear Medicine, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India

  • Deepa Thulasikumar Sunitha

    1   Department of Nuclear Medicine, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India
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Abstract

We present the case of a 54-year-old male with relapsing multiple myeloma (MM) complicated by biopsy-proven amyloid deposition, monitored over a span of 13 years with serial 18F-FDG PET/CT imaging. The patient experienced multiple treatment interruptions and disease relapses, with evolving imaging features ranging from widespread skeletal involvement to soft tissue plasmacytoma formation and associated amyloid deposition. This case highlights the evolving role of 18F-FDG PET/CT in detecting disease progression and treatment response in plasma cell dyscrasias with coexisting amyloidosis.

Keywords

18F-FDG PET/CT - multiple myeloma - amyloid - plasmacytoma - paramedullary


Publication History

Article published online:
09 December 2025

© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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