A New Approach to Atroposelective Biaryl Synthesis, Utilizing Chiral Carbon-Carbon Bridges1

Gerhard Bringmann; Paul A. Keller; Karin Rölfing

doi:10.1055/s-1994-22873

Synlett 1994; 1994(6): 423-424
DOI: 10.1055/s-1994-22873

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A New Approach to Atroposelective Biaryl Synthesis, Utilizing Chiral Carbon-Carbon Bridges¹

Gerhard Bringmann^* , Paul A. Keller, Karin Rölfing

^*Institute of Organic Chemistry, University of Würzburg, Am Hubland, D-97074 Würzburg, Germany

Abstract

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A new approach for the atropoenantioselective synthesis of biaryls is described that utilizes a chiral 2-carbon unit bridge to prefix the two aryl moieties prior to the coupling step. The degree of atroposelectivity appears to be determined by the degree of flexibility of this bridge.

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