PDF herunterladen
Synlett 1996; 1996(4): 317-318
DOI: 10.1055/s-1996-5423
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Regioselective and Enantioselective Metallation of A Tricarbonyl(η6-arene)chromium Complex Derived from 1,3-Dihydroisobenzofuran

Richard A. Ewin, Nigel S. Simpkins*
  • *Department of Chemistry, The University of Nottingham, University Park, Nottingham, NG7 2RD, UK, Fax (0115) 9513564; e-mail Nigel.Simpkins@Nottingham.ac.uk
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
31. Dezember 2000 (online)

 als PDF herunterladen  Lizenzen und Reprints Alle Artikel dieser Rubrik

The tricarbonyl(η6-arene)chromium complex derived from 1,3-dihydroisobenzofuran (phthalan) can be converted into chiral non-racemic derivatives, in up to 80% ee, via asymmetric deprotonation at the benzylic position using a chiral lithium amide base. Unexpectedly, different alkyllithium and lithium amide bases showed contrasting regioselectivities in deprotonation of the phthalan complex at either the benzylic or ortho positions.

enantioselective metallation - chiral lithium amide - tricarbonyl(η6-arene)chromium complex