Thorac Cardiovasc Surg 2000; 48(1): 46-54
DOI: 10.1055/s-2000-12142
Cardiovascular Review
© Georg Thieme Verlag Stuttgart · New York

Myocardial Protection In Hypoxic Immature Hearts[1]

K. Ihnken
  • Stanford University Hospital, Stanford, CA, USA
Further Information

Publication History

Publication Date:
31 December 2000 (online)

Current myocardial protection techniques in cyanotic immature hearts are not optimal. Despite successful surgical correction of congenital cardiac defects causing hypoxemia, myocardial dysfunction remains the leading cause of postoperative mortality. New studies indicate that the intraoperative reintroduction of molecular oxygen on cardiopulmonary bypass causes a reoxygenation injury leading to postoperative cardiac dysfunction. Biochemical and functional changes of reoxygenation injury can be avoided by several methods aimed at reducing oxygen free radical production and nitric oxide release. The present investigation provides an overview of our current understanding of pathogenesis, implication, and treatment of myocardial reoxygenation injury. New surgical concepts of myocardial protection including normoxic CPB and controlled reoxygenation are introduced.

1 Based on the paper awarded the Ernst-Derra Prize 1997 by the German Society for Thoracic and Cardiovascular Surgery

References

1 Based on the paper awarded the Ernst-Derra Prize 1997 by the German Society for Thoracic and Cardiovascular Surgery

Dr. Kai Ihnken

Stanford University Hospital

Department of Surgery

Room H3680

300 Pasteur Drive

Stanford, CA 94305

USA



Phone: 650-725-2181

Fax: 650-725-0791