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Dtsch Med Wochenschr 2000; 125(47): 1435-1438
DOI: 10.1055/s-2000-8490
Der Arzneistoff
© Georg Thieme Verlag Stuttgart · New York

Methotrexat

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Publication History

Publication Date:
31 December 2000 (online)

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Methotrexat (MTX) wird seit Ende der 40er Jahre in der Chemotherapie maligner Erkrankungen verwandt. Seit den 80er Jahren findet MTX als Basistherapeutikum der rheumatoiden Arthritis (RA) eine zunehmende Verbreitung [1]. Das Wissen über Nutzen und Risiko einer langfristigen Behandlung und über den molekularen Wirkmechanismus nimmt stetig zu. Chemisch ist MTX der Folsäure nahe verwandt [Abb. 1].

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Dr. med. F. Schröder

Abteilung Kardiologie und Angiologie Medizinische Hochschule Hannover

Carl-Neuberg-Straße 1

30625 Hannover

Prof. Dr. med. J. O. Schroeder

2. Medizinische Klinik und Poliklinik der Christian-Albrechts-Universität

Chemnitzstraße 33

24116 Kiel