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Thorac Cardiovasc Surg 2000; 48(2): 109-111
DOI: 10.1055/s-2000-9938
Case Report
© Georg Thieme Verlag Stuttgart · New York

Small Thymomas and Myasthenia Gravis: a Poorly Understood Association

S. Christiansen1 , A. Marx3 , R. Kiefer2 , H. H. Scheld1 , M. Semik1
  • 1Department of Cardiothoracic Surgery,
  • 2Department of Neurology, University of Münster, Münster, Germany
  • 3Department of Pathology, University of Würzburg, Würzburg, Germany
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Publication History

Publication Date:
31 December 2000 (online)

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Myasthenia gravis (MG) is associated with about 20 % of all patients with thymomas, but the occurrence in patients with small thymomas is rare. The pathogenetic relevante of these small thymomas for MG is poorly understood until now. We report an the clinical course of a 39-year-old female patient suffering from MG and undergoing thymectomy for a small thymoma and discuss the pathogenetic importance of small thymomas for MG.

Key words:

Myasthenia gravis - Small thymoma - Thymectomy - Pathogenesis

References

  • 1 Marx A, Schultz A, Wilisch A, Nenninger R, Müller-Hermelink H K. Autoimmunity in thymic epithelial tumors.  Dev Immunol.. 1998;  6 129-40
    PubMedGoogle Scholar
  • 2 Müller-Hermelink H K, Marx A, Kirchner Th. Advances in the diagnosis and classification of thymic epithelial tumors. In: Anthony PP and MacSween RNM, eds. Current Advances in Histopathology, Fascicle 16. Edinburgh: Churchill Livingstone 1994: 49-63
    Google Scholar
  • 3 Müller-Hermelink H K, Wilisch A, Schultz A, Marx A. Characterization of the human thymic microenvironment: lymphoepithelial interaction in normal thymus and thymoma.  Arch Histol Cytol.. 1997;  60 9-28
    PubMedGoogle Scholar
  • 4 Quintanilla-Martinez L, Wilkins E W, Choi N, Efird J, Hug E, Harris N L. Thymoma.  Cancer.. 1994;  74 606-17
    CrossrefPubMedGoogle Scholar
  • 5 Kirchner T, Schalke B, Marx A, Müller-Hermelink H K. Evaluation of prognostic features in thymic epithelial tumors.  Thymus.. 1989;  14 195-203
    PubMedGoogle Scholar
  • 6 Nenninger R, Schultz A, Hoffacker V. et al . Abnormal thymocyte development and generation of autoreactive T cells in mixed and cortical thymomas.  Lab Invest.. 1998;  78 743-53
    PubMedGoogle Scholar
  • 7 Schalke B CG, Mertens H G, Kirchner T, Wegener S, Müller-Hermelink H K. Long term treatment with azathioprine abolishes thymic lymphoid follicular hyperplasia in myasthenia gravis (letter).  Lancet.. 1987;  11 682
    PubMedGoogle Scholar
  • 8 Papatestas A E, Pozner J, Genkins G, Kornfeld P, Matta R J. Prognosis in occult thymomas in myasthenia gravis following transcervical thymectomy.  Arch Surg.. 1987;  122 1352-6
    CrossrefPubMedGoogle Scholar
  • 9 Venuta F, Rendina E A, Pescarmona E O. et al . Multimodality treatment of thymoma: a prospective study.  Ann Thorac Surg.. 1997;  64 1585-92
    CrossrefPubMedGoogle Scholar

Received for Publication: January 18, 1999

Dr. med. S. Christiansen

Department of Cardiothoracic Surgery Universität Münster

Albert-Schweitzer-Straße 33

48149 Münster

Germany

Phone: +49-251/834-8316

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