Cedranediolborane as a Borylating Agent for the Preparation of Boronic Acids: Synthesis of a Boronated Nucleoside Analogue

Yi-Lin Song; Christophe Morin

doi:10.1055/s-2001-10762

Synlett 2001; 2001(2): 0266-0268
DOI: 10.1055/s-2001-10762

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Cedranediolborane as a Borylating Agent for the Preparation of Boronic Acids: Synthesis of a Boronated Nucleoside Analogue

Yi-Lin Song^* , Christophe Morin

^*Laboratoire d'Etudes Dynamiques et Structurales de la Sélectivité (UMR CNRS 5616), Université Joseph Fourier, BP 53X, 38041 Grenoble Cedex 9, France; Fax +476 514 382; E-mail: christophe.morin§ujf-grenoble.fr

Abstract

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Cedranediolborane can be cross-coupled with aryl iodides under Pd(0) catalysis to yield aryl boronates which can easily be deprotected to form the corresponding free boronic acids. The application of this methodology has led to the preparation of a boronated nucleoside indole analogue.

cedrane - borylation - boronic acids - boronates - nucleoside

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