Thorac Cardiovasc Surg 2001; 49(2): 65-69
DOI: 10.1055/s-2001-11699
Original Cardiovascular
© Georg Thieme Verlag Stuttgart · New York

Surface Modification of Extracorporeal Circuits: Is there really an Impact on Cerebral Performance after Cardiopulmonary Bypass?[1]

F. Isgro, A.-H. Kiessling, H. Mittelstaedt, W. Saggau
  • Klinik für Herzchirurgie, Herzzentrum Ludwigshafen, Ludwigshafen, Germany
Further Information

Publication History

Publication Date:
31 December 2001 (online)

Background: Pathophysiology of extracorporeal circulation is multifactorial, and the link between newly developed “biomaterials” and clinical outcome is not easy to illustrate. Material and methods: We designed a randomized, double-blinded, prospective study in order to verify the impact of a new surface modification [SMARXT] in combination with an optimized blood air interface, on the cerebral performance after cardiopulmonary bypass. 80 patients were randomly divided into two subgroups (SMARXT vs. standard PVC control) and analyzed for the kinetic of cerebral ischemia markers neuronspecific enolase, protein S100 and neuropsychologically tested with the Mini-Mental-Status Test (MMST) before and after the operation. Results: We could not show significant differences of protein S100 and neuron-specific enolase (NSE) levels between SMARXT patients and the controls, but the incidence of neurological complications was exceptionally low. Although no statistically significant differences could be obtained for the MMST, the different pointloss between both groups trends toward a better cerebral performance in SMARXT patients. Conclusion: The use of a biologically inert circuit in combination with an optimized perfusion management seems to be worthy of recommondation.

1 The paper has been presented at the meeting ofThe Austrian, German and Swiss Society for Thoracic and Cardiovascular Surgery in Lucerne, Suisse, 02/1 1/2000

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1 The paper has been presented at the meeting ofThe Austrian, German and Swiss Society for Thoracic and Cardiovascular Surgery in Lucerne, Suisse, 02/1 1/2000

M.D. Frank Isgro

Klinik für Herzchirurgie, Herzzentrum Ludwigshafen

Bremserstraße 73

67063 Ludwigshafen

Germany

Phone: +49 621 503 4050

Fax: +49 621 503 4060

Email: isgrof@klilu.de

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