Graphite-Supported Ketodecarboxylation of Carboxylic Diacids

Julien Marquié; André Laporterie; Jacques Dubac; Nicolas Roques

doi:10.1055/s-2001-12319

Synlett 2001; 2001(4): 0493-0496
DOI: 10.1055/s-2001-12319

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Graphite-Supported Ketodecarboxylation of Carboxylic Diacids

Julien Marquié^* , André Laporterie, Jacques Dubac, Nicolas Roques

^*Hétérochimie Fondamentale et Appliquée (UMR CNRS 5069), Université Paul-Sabatier, 118 route de Narbonne, 31062 Toulouse Cedex, France; Fax (33) 5 61 55 82 04; E-mail: laporter@ramses.ups-tlse.fr

Abstract

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Thermal decarboxylative cyclization of several carboxylic diacids supported on graphite gave the corresponding five- and six-membered cycloalkanones in high yields. The process took advantage of the retention of diacid on graphite, even for high temperature experiments (450 °C), which avoid its vaporization. Moreover, the addition of catalyst is useless, the iron-containing inclusions present on graphite play this function. The reactions were also realized under microwave irradiation.

cycloalkanones - decarboxylation - diacids - graphite - microwaves

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