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Aktuelle Dermatologie 2001; 27(5): 150-154
DOI: 10.1055/s-2001-13110
ORIGINALARBEIT
© Georg Thieme Verlag Stuttgart · New York

Insektenstichähnliche Hautveränderungen als Initialmanifestation maligner hämatologischer Erkrankungen

Kasuistik und LiteraturübersichtInsect-Bite Like Reactions as Initial Manifestation of Malignant Hematological Diseases: Case Report and Literature ReviewBettina Dorfner1 , B. Weiss2 , T. Nüsse2 , M. Bohrer3 , V. Voigtländer1
  • 1 Hautklinik am Klinikum der Stadt Ludwigshafen (Direktor: Prof. Dr. med. V. Voigtländer)
  • 2 Medizinische Klinik A am Klinikum der Stadt Ludwigshafen (Direktor: Priv.-Doz. Dr. med. M. Uppenkamp)
  • 3 Institut für Pathologie am Klinikum der Stadt Ludwigshafen (Direktor: Prof. Dr. med. M. Bohrer)
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Publication History

Publication Date:
31 December 2001 (online)

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Zusammenfassung

Ein 80-jähriger Patient entwickelte am frontalen Kapillitium einen livid-rötlichen Knoten, der wegen des Verdachts eines Zeckenlymphozytoms erfolglos mit Tetrazyklinen behandelt wurde. Eine Biopsie des Knotens ließ ein myeloisches Infiltrat vermuten und führte in Verbindung mit der Knochenmarkhistologie und -zytologie zunächst zur Diagnose einer chronisch-myelomonozytären Leukämie (CMMoL). Im weiteren Verlauf entwickelte der Patient jedoch das Bild einer akuten Leukose mit über 90 % Blasten im peripheren Blut und Knochenmark. Die zytochemische und immunphänotypische Diagnostik ergab den Befund einer prä-T-ALL (akute lymphatische Leukämie).

Insect-Bite Like Reactions as Initial Manifestation of Malignant Hematological Diseases: Case Report and Literature Review

An 80-year old patient presented with a livid-red frontal nodule that was treated unsuccessfully with tetracyclines under the diagnosis of a borrelia lymphocytoma. Initially, histopathology of the nodule revealed a myeloic infiltration and, based on bone marrow smears and biopsy, a chronic-myelomonocytic leukemia (CMMoL) was diagnosed. In the course of the disease the patient developed an acute leukosis with more than 90 % blasts in the peripheral blood and bone marrow. Cytochemical and immunophenotypical diagnosis showed a pre-T-ALL (acute lymphoblastic leukemia with T-cell-phenotype).

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Dr. med. Bettina  Dorfner

Hautklinik Ludwigshafen

Bremserstraße 79
67063 Ludwigshafen

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