Tartaric Acid and Tartrates in the Synthesis of Bioactive Molecules

Arun K. Ghosh; Elena S. Koltun; Geoffrey Bilcer

doi:10.1055/s-2001-15217

REVIEW

Tartaric Acid and Tartrates in the Synthesis of Bioactive Molecules

Arun K. Ghosh*, Elena S. Koltun, Geoffrey Bilcer
Department of Chemistry, University of Illinois at Chicago, 845 West Taylor Street, Chicago, Illinois 60607, USA
Fax: +1(312)9960431; e-Mail: arunghos@uic.edu;

Abstract

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Abstract

A review on the syntheses of bioactive compounds published since 1995 using tartaric acid and its derivatives as synthons is presented.

1 Introduction
2 Acyclic 1,2-Diols
2.1 PQ-8
2.2 Panaxydol
2.3 Panaxytriol
2.4 (+)-Polyoxin J
2.5 Sphingofungin F
2.6 (+)-Bengamide E
3 Carbocycles
3.1 (-)-Rishitin
3.2 (-)-Methyl Jasmonate and (+)-Methyl Epijasmonate
3.3 (+)- and (-)-Isoterrein
3.4 Erythrina alkaloids
3.5 (+)-Condutirol-E
4 Furans and Pyrans
4.1 (-)-Koninginin A
4.2 (+)-Koninginin D
4.3 Thromboxane B₂
4.4 (-)-Kumausallene
4.5 Zaragozic Acid C
5 Lactones and Lactams
5.1 (-)-Cinatrin C1 and C3
5.2 (S,S)-Sapinofuranone B
5.3 (+)-Muricatacin
5.4 Syringolide, Secosyrin and Syributin
5.5 (+)-Boronolide
5.6 Pinolidoxin
5.7 l-Biopterin
6 Nitrogen Heterocycles
6.1 (-)-Anisomycin and (+)-Polyoxamic Acid
6.2 (-)-Deacetylanisomycin
6.3 Nectrisine
6.4 DAB-1, LAB-1
6.5 Lentiginosine
6.6 Trapoxin B
6.7 (+)-FR900482
6.8 Curasin A
7 Miscellaneous Compounds
8 Conclusion

Key words

tartaric acid - tartrate - synthesis - natural products - bioactive

Full Text

References

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