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Semin Musculoskelet Radiol 2001; 05(2): 095-098
DOI: 10.1055/s-2001-15659
Copyright © 2001 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

Adult T-Cell Leukemia

Jun Aoki1 , Noriko Sato1 , Nariyuki Oya1 , Tomio Inoue2 , Keigo Endo1 2
  • 1Department of Diagnostic Radiology; Gunma University School of Medicine, Maebashi, Japan and
  • 2Department of Nuclear Medicine, Gunma University School of Medicine, Maebashi, Japan
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Publication History

Publication Date:
31 December 2001 (online)

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ABSTRACT

Adult T-cell leukemia (ATL) is endemic in southwestern Japan, in the Caribbean islands, and in central Africa. Human T-cell lymphotropic virus type I (HTLV-I) is the etiologic agent of ATL. The clinical characteristics are (1) onset in adulthood, (2) subacute or chronic leukemia with rapidly progressive terminal course, (3) frequent skin lesions, (4) lymphadenopathy that characteristically spares the mediastinum, (5) hepatosplenomegaly, (6) hypercalcemia, and (7) a tendency toward geographical clustering. Although hypercalcemia and osteoclastic activity due to parathyroid hormone-related peptide are frequently reported histologically, radiographic abnormalities of bone are not common. Two major patterns of osteolytic lesions observed in ATL are ``punched-out'' lesions resembling multiple myeloma and osteolytic metastasis and subperiosteal bone resorptions similar to those in hyperparathyroidism.

KEYWORD

Bones - leukemia - lymphoma

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