Z Gastroenterol 2001; 39(7): 543-549
DOI: 10.1055/s-2001-15970
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© Karl Demeter Verlag im Georg Thieme Verlag Stuttgart · New York

Funktionelle Dyspepsie: Stein der Weisen oder viel Lärm um nichts?

Functional Dyspepsia: Philosophers' stone or much ado about nothingG. Stacher
  • Psychophysiologisches Laboratorium an der Universitätsklinik für Chirurgie, Wien, Österreich
Further Information

Publication History

30.6.2000

16.10.2000

Publication Date:
31 December 2001 (online)

Zusammenfassung

Ist mit der Stellung der Diagnose funktionelle Dyspepsie etwas gewonnen? 1998 empfahl eine in Rom zusammengetretene Arbeitsgruppe, diese Diagnose zu stellen bei anhaltenden oder rezidivierenden Schmerzen in Oberbauchmitte oder bei Sensationen wie vorzeitigem Sättigungsgefühl, Völlegefühl, Blähungen, Übelkeit, die im vergangenen Jahr mehr als 12 Wochen bestanden, weder durch Stuhlgang gelindert würden noch mit einer veränderten Stuhlfrequenz oder Stuhlkonsistenz einhergingen und sich kein zugrunde liegendes Leiden finde. Anamnese, physische Untersuchung und Ösophagogastroskopie wurden als Mindestaufwand empfohlen. Funktionelle Dyspepsie ist also eine Ausschlussdiagnose. Der Begriff ist unglücklich: Er suggeriert eine manifeste oder zu vermutende Funktionsstörung und dass zwischen Störungen definierter und solchen nicht eruierbarer Ursache ein grundlegender Unterschied bestünde - ernst zu nehmen wären nur die zuerst Genannten. Dass bestimmte Untersuchungen keine Ursache zutage brachten, bedeutet überdies nicht, dass keine existierte. Funktionell wird auch gleichbedeutend mit ideologiebefrachteten Begriffen wie Organneurose, Vegetative Dystonie und Psychosomatische Störung verwendet. Patienten mit funktioneller Dyspepsie weisen jedoch weder pathophysiologische, psychosoziale oder psychopathologische Charakteristika auf, noch gibt es eine spezifische Therapie. Diese hat sich nach den jeweiligen Symptomen zu richten. Es ist daher nicht zu erkennen, dass die Stellung der Diagnose funktionelle Dyspepsie für die Behandlung eines Patienten dienlich sein könnte. Wenn eine Kategorisierung wünschenswert erscheint, so brächte der Terminus idiopathische Dyspepsie klar zum Ausdruck, dass die Ursache der Beschwerden unerkannt ist.

Functional Dyspepsia: Philosophers' stone or much ado about nothing

Does it make sense to diagnose functional dyspepsia? In 1998, a committee gathered in Rome recommended to diagnose functional dyspepsia in patients with persistent or recurrent pain or discomfort centered in the upper abdomen but no disease likely to explain the symptoms, which are not exclusively relieved by defecation or associated with changed stool frequency or form. Careful history taking, physical examination and upper endoscopy during a symptomatic period off anti-secretory therapy are recommended as minimum workup. Functional dyspepsia thus is a diagnosis of exclusion. The term is unfortunate: It suggests the presence of a manifest or yet covert organ dysfunction and also a fundamental difference between disorders with defined and with unknown cause, only the former being serious. However, that a limited number of investigations failed to reveal a cause does not mean that there is no cause. Further, functional often is used synonymous with vague and ideology-ridden terms such as “organ neurosis”, “vegetative dystonia” and “psychosomatic disorder”. There are no unequivocal data showing that patients with functional dyspepsia share pathophysiological, psychosocial or psychopathological characteristics or that there is a specific therapy. In the individual patient, therapy has to be tailored according to the symptoms. It thus seems doubtful whether the diagnosis functional dyspepsia can, for a patient's treatment or otherwise, be of value. If a categorization is deemed inevitable, the term idiopathic dyspepsia would be preferable, as it unequivocally makes clear that the symptoms' cause is unrevealed.

Literatur

  • 1 Agréus L, Svärdsudd K, Nyrén O, Tibblin G. Irritable bowel syndrome and dyspepsia in the general population: Overlap and lack of stability over time.  Gastroenterology. 1995;  109 671-680
  • 2 Agréus L, Talley N J. Dyspepsia: Current understanding and management.  Annu Rev Med. 1998;  49 475-493
  • 3 American Gastroenterological Association Medical Position Statement . Evaluation of dyspepsia.  Gastroenterology. 1998;  114 579-581
  • 4 Armstrong D. Helicobacter pylori infection and dyspepsia.  Scand J Gastroenterol. 1996;  31 (Suppl. 215) 38-47
  • 5 Bennett E, Beaurepaire J, Langeluddecke P, Kellow J, Tennant C. Life stress and non-ulcer dyspepsia: A case-control study.  J Psychosom Med. 1991;  35 579-590
  • 6 Blum A L, Talley N J, O'Moráin C. et al. for the Omeprazole plus Clarithromycin and Amoxicillin Effect One Year after Treatment (OCAY) Study Group . Lack of effect of treating Helicobacter pylori infection in patients with nonulcer dyspepsia.  N Engl J Med. 1998;  339 1875-1881
  • 7 Champion M C, MacCannell K L, Thomson A B. et al . A double-blind randomized study of cisapride in the treatment of nonulcer dyspepsia. The Canadian Cisapride Nud Study Group.  Can J Gastroenterol. 1997;  11 127-134
  • 8 Chang C S, Chen G H, Kao C H. et al . The effect of Helicobacter pylori infection on gastric emptying of digestible and indigestible solids in patients with nonulcer dyspepsia.  Am J Gastroenterol. 1996;  91 474-479
  • 9 Coffin B, Azpiroz F, Guarner F, Malagelada J -R. Selective gastric hypersensitivity and reflex hyporeactivity in functional dyspepsia.  Gastroenterology. 1994;  107 1345-1351
  • 10 Diamant N E. Overview of functional gut disorders: A challenge.  Scand J Gastroenterol. 1995;  30 (Suppl. 213) 1-6
  • 11 Drossman D A. Importance of the psyche in heartburn and dyspepsia.  Aliment Pharmacol Ther. 1997;  11 (Suppl. 2) 57-67
  • 12 Rome II: A multinational consensus document on functional gastrointestinal disorders. Drossman DA, Corazziari E, Talley NJ, Thompson WG, Whitehead WE Gut 1999 45 (Suppl. II): II1-81
  • 13 The functional gastrointestinal disorders. Diagnosis, pathophysiology, and treatment. Drossman DA, Richter JE, Talley NJ et al A multinational consensus Boston; Little, Brown and Co 1994
  • 14 Finney J S, Kinnersley N, Hughes M, O'Brian-Tear C G, Lothian J. Meta-analysis of antisecretory and gastrokinetic compounds in functional dyspepsia.  J Clin Gastroenterol. 1998;  26 312-320
  • 15 Gilja O H, Hausken T, Wilhelmsen I, Berstad A. Impaired accomodation of proximal stomach to a meal in functional dyspepsia.  Dig Dis Sci. 1996;  41 689-696
  • 16 Glasbrenner B, Malfertheiner P, Nilius M. et al . Prevalence of Helicobacter pylori infection and dyspepsia in young adults in Germany.  Z Gastroenterol. 1996;  34 478-482
  • 17 Glasbrenner B, Weiler S, Ellenrieder V, Müller P, Adler G. Relationship between Helicobacter pylori infection, histological gastritis, and functional dyspepsia.  Hepatogastroenterology. 1998;  45 2238-2243
  • 18 Hallas J, Bytzer P. Screening for drug related dyspepsia: An analysis of prescription symmetry.  Eur J Gastroenterol Hepatol. 1998;  10 27-32
  • 19 Haug T T, Wilhelmsen I, Berstad A, Ursin H. Life events and stress in patients with functional dyspepsia compared with patients with duodenal ulcer and healthy controls.  Scand J Gastroenterol. 1995;  30 524-530
  • 20 Hausken T, Svebak S, Wilhelmsen I. et al . Low vagal tone and antral dysmotility in patients with functional dyspepsia.  Psychosom Med. 1993;  55 12-22
  • 21 Holtmann G, Goebell H, Holtmann M, Talley N J. Dyspepsia in healthy blood donors: Patterns of symptoms and association with Helicobacter pylori.  Dig Dis Sci. 1994;  39 1090-1098
  • 22 Holtmann G, Goebell H, Talley N J. Impaired small intestinal peristaltic reflexes and sensory thresholds are independent functional disturbances in patients with chronic unexplained dyspepsia.  Am J Gastroenterol. 1996;  91 485-491
  • 23 Holtmann G, Stanghellini V, Talley N J. Nomenclature of dyspepsia, dyspepsia subgroups and functional dyspepsia: Clarifying the concepts.  Baillière's Clin Gastroenterol. 1998;  12 417-433
  • 24 Hui W M, Shiu L P, Lam S K. The perception of life events and daily stress in nonulcer dyspepsia.  Am J Gastroenterol. 1991;  86 292-296
  • 25 Jebbink H JA, van Berge-Henegouwen G P, Akkermans L MA, Smout A JPM. Small intestinal motor abnormalities in patients with functional dyspepsia demonstrated by ambulatory manometry.  Gut. 1996;  38 694-700
  • 26 Johannessen T, Petersen H, Kristensen P. et al . The intensity and variability of symptoms in dyspepsia.  Scand J Prim Health Care. 1993;  11 50-55
  • 27 Jones R, Lydeard S. Prevalence of symptoms of dyspepsia in the community.  BMJ. 1989;  298 30-32
  • 28 Kellow J E, Cowan H, Shuter B. et al . Efficacy of cisapride therapy in functional dyspepsia.  Aliment Pharmacol Ther. 1995;  9 153-160
  • 29 Klatt S, Pieramico O, Guethner C. et al . Gastric hypersensitivity in nonulcer dyspepsia: An inconsistent finding.  Dig Dis Sci. 1997;  42 720-723
  • 30 Langeluddecke P, Goulston K, Tennant C. Psychological factors in dyspepsia of unknown cause: A comparison with peptic ulcer disease.  J Psychosom Res. 1990;  34 215-222
  • 31 Lémann M, Dedering J P, Flourié B. et al . Abnormal perception of visceral pain in response to gastric distension in chronic idiopathic dyspepsia. The irritable stomach syndrome.  Dig Dis Sci. 1991;  36 1249-1254
  • 32 Maes B D, Ghoos Y F, Hiele M I, Rutgeerts P J. Gastric emptying rate of solids in patients with nonulcer dyspepsia.  Dig Dis Sci. 1997;  42 1158-1162
  • 33 Magni G, di Mario F, Bernasconi G, Mastropaolo G. DSM-III diagnoses associated with dyspepsia of unknown cause.  Am J Psychiatry. 1987;  144 1222-1223
  • 34 Malfertheiner P, McColl K (coordinators), Baldi F, Dinelli M, Festi D. et al. (participants) . Workshop 5, Dyspepsia.  Eur J Gastroenterol Hepatol. 1997;  9 624-625
  • 35 McColl K, Murray L, El-Omar E. et al . Symptomatic benefit from eradicating Helicobacter pylori infection in patients with nonulcer dyspepsia.  N Engl J Med. 1998;  339 1869-1874
  • 36 Mearin F, Cucala M, Azpiroz F, Malagelada J -R. The origin of symptoms on the brain-gut axis in functional dyspepsia.  Gastroenterology. 1991;  101 999-1006
  • 37 Mitscherlich A. Krankheit als Konflikt. Studien zur psychosomatischen Medizin I Frankfurt; Suhrkamp 1969 5. Aufl.: 13
  • 38 Møller Hansen J, Bytzer P, Muckadell de Schaffalitzky O B. Placebo-controlled trial of cisapride and nizatidine in unselected patients with functional dyspepsia.  Am J Gastroenterol. 1998;  93 368-374
  • 39 Nandurkar S, Talley N J, Xia H. et al . Dyspepsia in the community is linked to smoking and aspirin use but not Helicobacter pylori infection.  Arch Intern Med. 1998;  158 1427-1433
  • 40 Penston J G, Pounder R E. A survey of dyspepsia in Great Britain.  Aliment Pharmacol Ther. 1996;  10 83-89
  • 41 Quartero A O, De Witt N J, Lodder A C. et al . Disturbed solid-phase gastric emptying in functional dyspepsia. A meta-analysis.  Dig Dis Sci. 1998;  43 2028-2033
  • 42 Richter J E. Dyspepsia: Organic causes and differential characteristics from functional dyspepsia.  Scand J Gastroenterol. 1991;  26 (Suppl. 182) 11-16
  • 43 Richter J E. and the Working Team for Functional Esophageal Disorders .The functional gastrointestinal disorders. Diagnosis, pathophysiology, and treatment. Drossman DA, Richter JE, Talley NJ, Thompson WG, Corazziari E, Whitehead WE A multinational consensus Boston; Little, Brown and Co 1994: 25-70
  • 44 Salet G AM, Samsom M, Roelofs J MM. et al . Responses to gastric distention in functional dyspepsia.  Gut. 1998;  42 823-829
  • 45 Scott A M, Kellow J E, Shuter B. et al . Intragastric distribution and gastric emptying of solids and liquids in functional dyspepsia. Lack of influence of symptom subgroups and H. pylori-associated gastritis.  Dig Dis Sci. 1993;  38 2247-2254
  • 46 Stanghellini V, Tosetti C, Paternicò A. et al . Risk indicators of delayed gastric emptying of solids in patients with functional dyspepsia.  Gastroenterology. 1996;  110 1036-1042
  • 47 Tack J, Piessevaux H, Coulie B, Caenepeel P, Janssens J. Role of impaired gastric accomodation to a meal in functional dyspepsia.  Gastroenterology. 1998;  115 1346-1352
  • 48 Talley N J, Boyce P, Jones M. Dyspepsia and health care seeking in a community. How important are psychological factors?.  Dig Dis Sci. 1998;  43 1016-1022
  • 49 Talley N J, Colin-Jones D, Koch K L. et al . Functional dyspepsia. A classification with guidelines for diagnosis and management.  Gastroenterology International. 1991;  4 145-160
  • 50 Talley N J, Ellard K, Jones M, Tennant C, Piper D W. Suppression of empotions in essential dyspepsia and chronic duodenal ulcer. A case-control study.  Scand J Gastroenterol. 1988;  23 337-340
  • 51 Talley N J, Evans J M, Fleming K C, Harmsen W S, Zinsmeister A R, Melton L J III. Nonsteroidal antiinflammatory drugs and dyspepsia in the elderly.  Dig Dis Sci. 1995;  40 1345-1350
  • 52 Talley N J, Fung L H, Gilligan I J, McNeil D, Piper D W. Association of anxiety, neuroticism, and depression with dyspepsia of unknown cause. A case-control study.  Gastroenterology. 1986;  90 886-892
  • 53 Talley N J, Hunt R H. What role does Helicobacter pylori play in nonulcer dyspepsia? Arguments for and against H. pylori being associated with dyspeptic symptoms.  Gastroenterology. 1997;  113 (Suppl.) S67-77
  • 54 Talley N J, Janssens J, Lauritsen K, Racz I, Bolling-Sternevald E. Eradication of Helicobacter pylori in functional dyspepsia: Randomised double blind placebo controlled trial with 12 months' follow-up. The Optimal Regimen Cures Helicobacter Induced Dyspepsia (ORCHID) Study Group.  BMJ. 1999;  318 833-837
  • 55 Talley N J, Meineche-Schmid V, Paré P. et al . Efficacy of omeprazole in functional dyspepsia: Double blind, randomized, placebo-controlled trials (the Bond and Opera studies).  Aliment Pharmacol Ther. 1998;  12 1055-1065
  • 56 Talley N J, Piper W. A prospective study of social factors and major life event stress in patients with dyspepsia of unknown cause.  Scand J Gastroenterol. 1987;  22 268-272
  • 57 Talley N J, Stanghellini V, Heading R C. et al . Functional gastroduodenal disorders.  Gut. 1999;  45 (Suppl. II) II37-42
  • 58 Talley N J, Vakil N, Ballard E D II, Fennerty M B. Absence of benefit of eradicating Helicobacter pylori in patients with nonulcer dyspepsia.  N Engl J Med. 1999;  341 1106-1011
  • 59 Talley N J, Weaver A L, Tesmer D L, Zinsmeister A R. Lack of discriminant value of dyspepsia subgroups in patients referred for upper endoscopy.  Gastroenterology. 1993;  105 1378-1386
  • 60 Talley N J, Zinsmeister A R, Schleck C D, Melton L J III. Dyspepsia and dyspepsia subgroups: A population-based study.  Gastroenterology. 1992;  102 1259-1268
  • 61 Troncon L EA, Thompson D G, Ahluwalia N K, Barlow J, Heggie L. Relations between upper abdominal symptoms and gastric distension abnormalities in dysmotility like functional dyspepsia and after vagotomy.  Gut. 1995;  37 17-22
  • 62 Veldhuyzen van Zanten S JO, Cleary C, Talley N J. et al . Drug treatment of functional dyspepsia: A systematic analysis of trial methodology with recommendations for design of future trials.  Am J Gastroenterol. 1996;  91 660-673
  • 63 Veldhuyzen van Zanten S JO, Sherman P M. Helicobacter pylori infection as a cause of gastritis, duodenal ulcer, gastric cancer and nonulcer dyspepsia: A systematic overview.  Can Med Assoc J. 1994;  150 177-185
  • 64 von Uexküll Th. Funktionelle Syndrome in der inneren Medizin. von Uexküll Th Lehrbuch der Psychosomatischen Medizin München; Urban & Schwarzenberg 1981 2. Aufl.: 453-463
  • 65 von Uexküll Th, Köhle K. Funktionelle Syndrome. Adler RH, Herrmann JM, Köhle K, Schonecke OW, von Uexküll Th, Wesiack W Thure von Uexküll Psychosomatische Medizin München; Urban & Schwarzenberg 1998 5. Aufl.: 655-669
  • 66 Wegener M, Börsch G, Schaffstein J, Reuter C, Leverkus F. Frequency of idiopathic gastric stasis and intestinal transit disorders in essential dyspepsia.  J Clin Gastroenterol. 1989;  11 163-168
  • 67 Werdmuller B F, van der Putten A B, Loffeld R J. Symptom clusters cannot be used in distinguishing Helicobacter pylori positive or negative patients with functional dyspepsia.  Neth J Med. 1998;  53 164-167
  • 68 Wilmer A, van Cutsem E, Andrioli A. et al . Ambulatory gastrojejunal manometry in severe motility-like dyspepsia: Lack of correlation between dysmotility, symptoms, and gastric emptying.  Gut. 1998;  42 235-242
  • 69 Wolfe M M, Lichtenstein D R, Singh G. Gastrointestinal toxicity of nonsteroidal antiinflammatory drugs.  N Engl J Med. 1999;  340 1888-1899

Univ.-Prof. Dr. Georg Stacher

Psychophysiologisches Laboratorium

Währinger Gürtel 18-20

1090 Wien

Österreich

Email: georg.stacher@akh-wien.ac.at

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