Facial plast Surg 2001; 17(1): 079-085
DOI: 10.1055/s-2001-16368
Copyright © 2001 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

Collagen, Human Collagen, and Fat: The Search for a Three-Dimensional Soft Tissue Filler

Anthony P. Sclafani1,3 , Thomas Romo III2,3
  • 1Division of Facial Plastic Surgery, The New York Eye and Ear Infirmary, New York, New York
  • 2Facial Plastic Surgery, Lenox Hill Hospital, New York, New York
  • 3New York Medical College, Valhalla, New York
Further Information

Publication History

Publication Date:
31 December 2001 (online)


As the body ages, not only are the soft tissues of the face subject to gravity but they also may undergo progressive atrophy. Suspensory procedures may return the tissues to a more youthful position, but the atrophic changes are left uncorrected and produce an aged appearance. Three-dimensional (3-D) soft tissue fillers ideally would replace the bulk that was lost. Safety, persistence, and verisimilitude to the native tissues should be optimal in useful 3-D fillers. To date, no such material has been described, but there has been a resurgence in natural materials for this purpose. This article serves as an update on human-derived soft tissue fillers.