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Z Gastroenterol 2001; 39(9): 807-813
DOI: 10.1055/s-2001-17197
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© Karl Demeter Verlag im Georg Thieme Verlag Stuttgart · New York

Matrixmetalloproteinasen als Promotoren der Tumorinvasion und Metastasierung

Eine Übersicht unter besonderer Berücksichtigung des GastrointestinaltraktesMatrix metalloproteinases: Promoters of tumor invasion and metastasis - A review with focus on gastrointestinal tumorsE. Roeb, S. Matern
  • Medizinische Klinik III Universitätsklinikum der RWTH Aachen
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Publikationsverlauf

1.12.2000

18.1.2001

Publikationsdatum:
14. September 2001 (online)

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Zusammenfassung

Die Degradation von Basalmembran und extrazellulärer Matrix ist eine Voraussetzung für die Invasion und Metastasierung von Tumorzellen. Die dazu erforderliche Proteolyse erfolgt unter anderem durch Matrixmetalloproteinasen und ist streng kontrolliert durch spezifische endogene Proteaseinhibitoren.

Dieser Review fasst den gegenwärtigen Stand der Erkenntnisse über die Rolle der Matrixmetalloproteinasen im Wachstum, der Invasion und Metastasierung zusammen und fokussiert sich auf die Bedeutung der Matrixmetalloproteinasen bei gastrointestinalen Tumoren.

Matrix metalloproteinases: Promoters of tumor invasion and metastasis - A review with focus on gastrointestinal tumors

Degradation of basement membrane and extracellular matrix is crucial for invasion and metastasis of tumor cells. Proteolysis occurs via matrix metalloproteinases and is tightly controlled by specific endogenous proteinase inhibitors.

This review will summarize the current view on the role of matrix metalloproteinases in tumor growth, invasion and metastasis and focus on the importance of matrix metalloproteinases in gastrointestinal cancer.

Schlüsselwörter

Matrixmetalloproteinasen - TIMP - Kolonkarzinom - Invasion - Metastasierung

Key words

Matrix Metalloproteinases - TIMP - Colon Carcinom - Invasion - Metastasis

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Anschrift für die Verfasser

PD Dr. Elke Roeb

Medizinische Klinik III
Universitätsklinikum der RWTH Aachen

Pauwelsstraße 30

52057 Aachen

eMail: elke.roeb@post.klinikum.rwth-aachen.de