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Int J Sports Med 2001; 22(7): 482-497
DOI: 10.1055/s-2001-17606
Review/Physiology and Biochemistry

© Georg Thieme Verlag Stuttgart · New York

Physiology and Pathophysiology of the Serotonergic System and its Implications on Mental and Physical Performance. Part II

H. K. Strüder1 , H. Weicker2
  • 1Institute of Theory and Practice of Training and Movement, German Sport University, Cologne, Germany
  • 2Department of Sports Medicine, Ruprecht-Karls-University, Heidelberg, Germany
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Publication History

Publication Date:
04 October 2001 (online)

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As shown in the first part of this review, well equilibrated neurotransmission in which 5-HT plays a dominant role is important for proper neuromodulation and adjustment of neuronal network elements. Adequate 5-HT system function supports regulation of intercommunicative neuronal transmission in the brain, which optimizes behavioral neuromodulation during and after different forms of exertions, thereby preventing transient dysregulation. Impairment of neuromodulation and neuronal network in the brain with transient dysfunctions or permanent substantial deficits at manifestation of various types of depression results from prevalent impairment of 5-HT neurotransmission and its central interaction with other neurotransmitter systems. Exercise-induced increase of free tryptophan (TRP) in blood occurs due to liberation from albumin, which is caused by adrenergically induced lipolysis of free fatty acids and results in higher free TRP uptake into the brain. Consecutively enhanced serotonin (5-HT) biosynthesis does not per se initiate mood impairment or central fatigue. It is suggested that in overtrained athletes central fatigue, mental deficiency and behavioral alterations with depressive mood are probably not primarily caused by metabolic and neuromuscular alterations. The primary trigger of these transient behavioural alterations might instead be initiated by a central exhaustive exercise stress which elicits impairment of complex neuromodulation, also afflicting the interaction of central neurotransmitters or hypothalamic neuropeptides and releasing factors. In a consecutive correction of the variation, the implication of the serotonergic system on the central neuromodular disturbance might improve or prevent the progressive course both in transient and in permanent mental disorders. However, an unsuccessful attempt to improve the depressive symptomatology leads mostly to an overproportional exaggeration of the behavioral changes.

Key words:

Raphe nuclei, signal transduction, neuromodulation, neuronal network, prolactin, depression, overtraining, eating disorders.

References

  • 1 Abdul-Rahman A, Dahlgren N, Johansson B B, Siesjö B K. Increase in local cerebral blood flow induced by circulating adrenaline. Involvement of blood-brain barrier dysfunction.  Acta Physiol Scand. 1979;  107 227-232
    PubMedGoogle Scholar
  • 2 Abele-Brehm A, Brehm W. Zur Konzeptualisierung und Messung von Befindlichkeit. Die Entwicklung der Befindlichkeitsskalen (BFS).  Diagnostica. 1986;  32 209
    PubMedGoogle Scholar
  • 3 Badawy A AB. The functions and regulation of tryptophan pyrrolase.  Life Sci. 1977;  21 755-768
    CrossrefPubMedGoogle Scholar
  • 4 Badawy A AB, Evans M. Inhibition of rat liver trypotphan pyrrolase activity and elevation of brain tryptophan concentration by administration of antidepressants.  Biochemical Pharmacology. 1981;  30 1211-1216
    CrossrefPubMedGoogle Scholar
  • 5 Badawy A AB, Morgan J. Tryptophan and tryptophan pyrrolase in haem regulation.  Biochem J. 1982;  206 451-460
    PubMedGoogle Scholar
  • 6 Bailey S P, Davis J M, Ahlborn E N. Effect of increased brain serotonergic activity on endurance performance in the rat.  Acta Physiol Scand. 1992;  145 75-76
    PubMedGoogle Scholar
  • 7 Bailey S P, Davis J M, Ahlborn E N. Neuroendocrine and substrate responses to altered brain 5-HT activity during prolonged exercise to fatigue.  J Appl Physiol. 1993;  74 3006-3012
    PubMedGoogle Scholar
  • 8 Bailey S P, Davis J M, Ahlborn E N. Serotonergic agonists and antagonists affect endurance performance in the rat.  Int J Sports Med. 1993;  14 330-333
    PubMedGoogle Scholar
  • 9 Banfi G, Marinelli M, Roi G S, Giacometti M. Platelet indices in athletes performing a race in altitude environment.  J Clin Lab Anal. 1995;  9 34-36
    PubMedGoogle Scholar
  • 10 Barron J L, Noakes T D, Levy W, Smith C, Millar R P. Hypothalamic dysfunction in overtrained athletes.  J Clin Endocrinol Metab. 1985;  60 803-806
    PubMedGoogle Scholar
  • 11 Baumgarten H G, Grozdanovic Z. Die Rolle des Serotonins in der Verhaltensmodulation.  Fortschr Neurol Psychiat. 1995;  63 3-8
    Article in Thieme ConnectPubMedGoogle Scholar
  • 12 Baumgarten H G, Grozdanovic Z. Psychopharmacology of central serotonergic systems.  Pharmacopschiat. 1995;  28 73-79
    Article in Thieme ConnectPubMedGoogle Scholar
  • 13 Biegon A, Weizman A, Karp L, Ram A, Tiano S, Wolff M. Serotonin 5-HT2 receptor binding on blood platelets - a peripheral marker for depression?.  Life Sci. 1987;  41 2485-2492
    CrossrefPubMedGoogle Scholar
  • 14 Blomstrand E, Celsing F, Newsholme E A. Changes in plasma concentration of aromatic and branched chain amino acids during sustained exercise in man and their possible role in fatigue.  Acta Physiol Scand. 1988;  133 115-121
    PubMedGoogle Scholar
  • 15 Blomstrand E, Hassmén P, Ekblom B, Newsholme E A. Administration of branched-chain amino acids during sustained exercise - effects on performance and on plasma concentration of some amino acids.  Eur J Appl Physiol. 1991;  63 83-88
    CrossrefPubMedGoogle Scholar
  • 16 Blomstrand E, Hassmén P, Newsholme E A. Effect of branched-chain amino acid supplementation on mental performance.  Acta Physiol Scand. 1991;  143 225-226
    PubMedGoogle Scholar
  • 17 Bond S W, Crabbe S, Sanders M C. Pharmacotherapy of eating disorders: a critical review.  Drug Intel Clin Pharm. 1986;  20 659-665
    PubMedGoogle Scholar
  • 18 Brewerton T D, Jimerson D C. Studies of serotonin function in anorexia nervosa.  Psychiatry Res. 1996;  62 31-42
    CrossrefPubMedGoogle Scholar
  • 19 Calders P, Pannier J L, Matthys D M, Lacroix E M. Pre-exercise branched-chain amino acid administration increases endurance performance in rats.  Med Sci Sports Exerc. 1997;  29 1182-1186
    PubMedGoogle Scholar
  • 20 Chaouloff F. Physical exercise and brain monoamines: a review.  Acta Physiol Scand. 1989;  137 1-13
    PubMedGoogle Scholar
  • 21 Chaouloff F. Effects of acute physical exercise on central serotonergic systems.  Med Sci Sports Exerc. 1997;  29 58-62
    PubMedGoogle Scholar
  • 22 Chaouloff F, Elghozi J L, Guezennec Y, Laude D. Effects of conditioned running on plasma, liver and brain tryptophan and on brain 5-hydroxytryptamine metabolism of the rat.  Br J Pharmacol. 1985;  86 33-41
    PubMedGoogle Scholar
  • 23 Chaouloff F, Kennett G A, Serrurier B, Merina D, Curzon G. Amino acid analysis demonstrates that increased plasma free tryptophan causes the increase of brain tryptophan during exercise in rat.  J Neurochem. 1986;  46 1647-1650
    Google Scholar
  • 24 Chaouloff F, Laude D, Elghozi J L. Physical exercise: evidence for differential consequences of tryptophan on 5-HT synthesis and metabolism in central serotonergic cell bodies and terminals.  J Neural Transm. 1989;  78 121-130
    CrossrefPubMedGoogle Scholar
  • 25 Crow S J, Mitchell J E. Rational therapy of eating disorders.  Drugs. 1994;  48 372-379
    PubMedGoogle Scholar
  • 26 Da Prada M, Cesura A M, Launay J M, Richards J G. Platelets as a model for neurones?.  Experientia. 1988;  44 115-126
    PubMedGoogle Scholar
  • 27 Davids E, Lesch K P. Der 5-HT1A-Rezeptor: Ein neues Wirkprinzip psychopharmakologischer Therapiestrategien?.  Fortschr Neurol Psychiat. 1996;  64 460-472
    PubMedGoogle Scholar
  • 28 Davis J M. Carbohydrates, branched-chain amino acids, and endurance: the central fatigue hypothesis.  Int J Sport Nutr. 1995;  5 29-38
    PubMedGoogle Scholar
  • 29 Davis J M, Bailey S P. Possible mechanisms of central nervous system fatigue during exercise.  Med Sci Sports Exerc. 1997;  29 45-57
    PubMedGoogle Scholar
  • 30 Davis J M, Bailey S P, Jackson D A, Strasner A B, Morehouse S L. Effects of a serotonin (5-HT) agonist during prolonged exercise to fatigue in humans.  Med Sci Sports Exerc. 1993;  25 S78
    PubMedGoogle Scholar
  • 31 Davis J M, Bailey S P, Woods J A, Galiano F J, Hamilton M T, Bartoli W P. Effects of carbohydrate feedings on plasma free tryptophan and branched-chain amino acids during prolonged cycling.  Eur J Appl Physiol. 1992;  65 513-519
    CrossrefPubMedGoogle Scholar
  • 32 De Palo E F, Metus P, Gatti R, Previti O, Bigon L, De Palo C B. Branched-chain amino acids chronic treatment and muscular exercise performance in athletes: a study through plasma acetyl-carnitine levels.  Amino Acids. 1993;  4 255-266
    PubMedGoogle Scholar
  • 33 Dixon G, Eurman P, Stern B E, Schwartz B, Rebar R W. Hypothalamic function in amenorrheic runners.  Fertility and Sterility. 1984;  42 377-383
    PubMedGoogle Scholar
  • 34 Dunn A, Dishmann R. Exercise and the neurobiology of depression.  Exerc Sport Sci Rev. 1991;  19 41-98
    PubMedGoogle Scholar
  • 35 Fernstrom J D, Wurtman R J. Brain serotonin content: physiological regulation by plasma neutral amino acids.  Science. 1971;  178 414-416
    PubMedGoogle Scholar
  • 36 Friedman P A, Kappelman A H, Kaufman S. Partial purification and characterization of tryptophan hydroxylase from rabbit hind brain.  J Biol Chem. 1972;  247 4165-4173
    PubMedGoogle Scholar
  • 37 Fry R W, Morton A R, Keast D. Overtraining in athletes.  Sports Med. 1991;  12 32-65
    CrossrefPubMedGoogle Scholar
  • 38 Galiano F J, Davis J M, Baily S P, Woods J A, Hamilton M. Physiologic, endocrine and performance effects of adding branched chain amino acids to a 6 % carbohydrate-electrolyte beverage during prolonged cycling.  Med Sci Sports Exerc. 1991;  23 14
    PubMedGoogle Scholar
  • 39 Gleeson M, Blannin A K, Sewell D A. Short-term changes in the blood leucocyte and platelet count following different durations of high-intensity treadmill running.  J Sports Sci. 1995;  13 115-123
    PubMedGoogle Scholar
  • 40 Graeff F G. Serotonergic systems.  Psychiat Clin North America. 1997;  20 723-739
    PubMedGoogle Scholar
  • 41 Halmi K A. The state of research in anorexia nervosa and bulimia.  Psychiatric Developments. 1983;  3 247-262
    PubMedGoogle Scholar
  • 42 Han L, Nielsen D A, Rosenthal N E, Jefferson K, Kaye W, Murphy D, Altemus M, Humphries J, Cassano G, Rotondo A, Virkkunen M, Linnoila M, Goldman D. No coding variant of the tryptophan hydroxylase gene detected in seasonal affective disorder, obsessive-compulsive disorder, anorexia nervosa, and alcoholism.  Biol Psychiatry. 1999;  45 615-619
    CrossrefPubMedGoogle Scholar
  • 43 Hassmén P, Blomstrand E, Ekblom B, Newsholme E A. Branched-chain amino acid supplementation during 3-km competitive run: mood and cognitive performance.  Nutrition. 1994;  10 405-410
    PubMedGoogle Scholar
  • 44 Hefler S K, Wideman L, Gaesser G A, Weltman A. Branched-chain amino acid (BCAA) supplementation improves endurance performance in competitive cyclists.  Med Sci Sports Exerc. 1995;  27 S 149
    PubMedGoogle Scholar
  • 45 Hoyer D. International union of pharmacology classification of receptors for 5-hydroxytryptamine (serotonin).  Pharmacol Rev. 1993;  46 157
    PubMedGoogle Scholar
  • 46 Hoyer D, Middlemiss D N. The pharmacology of the terminal 5-HT autoreceptors in mammalian brain: evidence for species differences.  Trends Pharmacol Sci. 1989;  10 130-132
    CrossrefPubMedGoogle Scholar
  • 47 Hudson J I, Pope H G, Jonas M D, Yurgelun-Todd D. Treatment of anorexia nervosa with antidepressants.  J Clin Psychopharmacol. 1985;  5 17-23
    PubMedGoogle Scholar
  • 48 Jakeman P M, Hawthorne J E, Maxwell S RJ, Kendall M J, Holder G. Evidence for downregulation of hypothalamic 5-hydroxytryptamine receptor function in endurance-trained athletes.  Exper Physiol. 1994;  79 461-464
    PubMedGoogle Scholar
  • 49 Kaplan L M. Herrisons principles of internal medicine. Grayhill 1998: 584-592
    Google Scholar
  • 50 Kaye W, Gendall K, Strober M. Serotonin neuronal function and selective serotonin reuptake inhibitor treatment in anorexia and bulimia nervosa.  Biol Psychiatry. 1998;  44 825-838
    CrossrefPubMedGoogle Scholar
  • 51 Keizer H A. Hormonal responses in women as a function of physical exercise and training.  Int J Sports Med. 1987;  8 137-174
    PubMedGoogle Scholar
  • 52 Kreider R B, Miriel V, Bertun E. Amino acid supplementation and exercise performance. Analysis of the proposed ergogenic value.  Sports Med. 1993;  16 190-209
    PubMedGoogle Scholar
  • 53 Kuipers H, Keizer H A. Overtraining in elite athletes: review and directions for the future.  Sports Med. 1988;  6 79-92
    CrossrefPubMedGoogle Scholar
  • 54 Lambert M, Velloza P, Wilson G. The effect of carbohydrate and branched-chain amino acid supplementation on cycling performance and mental fatigue. Aberdeen; 9th Int. Conference Biochemistry of Exercise 1994: 53
    Google Scholar
  • 55 Lehmann M, Gastmann U, Petersen K G, Bachl N, Seidel A, Khalaf A K, Fischer S, Keul J. Training-overtraining: performance, and hormone levels, after a defined increase in training volume versus intensity in experienced middle- and long-distance runners.  Br J Sport Med. 1992;  26 233-242
    CrossrefPubMedGoogle Scholar
  • 56 Leibowitz S F. The role of serotonin in eating disorders.  Drugs. 1990;  39 33-48
    PubMedGoogle Scholar
  • 57 Litt I F, Glader L. Anorexia nervosa, athletics, and amenorrhea.  J Pediatrics. 1986;  109 150-153
    PubMedGoogle Scholar
  • 58 Long D, Blake M, McNaughton L, Angle B. Hematological and biochemical changes during a short triathlon competition in novice triathletes.  Eur J Appl Physiol. 1990;  61 93-99
    CrossrefPubMedGoogle Scholar
  • 59 Madsen K, Christensen D. Administration of glucose, glucose plus branched-chain amino acids or placebo during sustained exercise and their effects on a 100 km bike performance. Aberdeen; 9th Int. Conference Biochemistry of Exercise 1994: 35
    Google Scholar
  • 60 Mans A M, Biebuyck J F, Hawkins R A. Ammonia selectively stimulates neutral amino acid transport across blood-brain barrier.  Am J Physiol. 1983;  245 C74-C77
    PubMedGoogle Scholar
  • 61 Marvin G, Sharma A, Aston W, Field C, Kendall M J, Jones D A. The effects of buspirone on perceived exertion and time to fatigue in man.  Exp Physiol. 1997;  82 1057-1060
    PubMedGoogle Scholar
  • 62 McMenamy R H. Binding of indole analogues to human serum albumin. Effects of fatty acids.  J Biol Chem. 1965;  240 4235-4243
    PubMedGoogle Scholar
  • 63 McMenamy R H, Oncley J L. The specific binding of L-tryptophan to serum albumin.  J Biol Chem. 1958;  233 1436-1447
    PubMedGoogle Scholar
  • 64 Meeusen R, De Meirleir K. Exercise and brain neurotransmission.  Sports Med. 1995;  20 160-188
    PubMedGoogle Scholar
  • 65 Meeusen R, Roeykens J, Magnus L, Keizer H, De Meirleir K. Endurance performance in humans: the effect of a dopamine precursor or a specific serotonin (5-HT2A/2C) antagonist.  Int J Sports Med. 1997;  18 571-577
    PubMedGoogle Scholar
  • 66 Mittleman K D, Ricci M R, Bailey S P. Branched-chain amino acids prolong exercise during heat stress in men and women.  Med Sci Sports Exerc. 1998;  30 83-91
    PubMedGoogle Scholar
  • 67 Monteleone P, Brambilla F, Bortolotti F, LaRocca A, Maj M. Prolactin response to d-fenfluramine is blunted in people with anorexia nervosa.  Brit J Psychiatry. 1998;  172 438-442
    PubMedGoogle Scholar
  • 68 Murphy D L, Andrews A M, Wichems C H, Li Q, Tohda M, Greenberg B. Brain serotonin neurotransmission: an overview and update with an emphasis on serotonin subsystem heterogeneity, multiple receptors, interactions with other neurotransmitter systems, and consequent implications for understanding the actions of serotonergic drugs.  1998;  59 4-12
    PubMedGoogle Scholar
  • 69 Nathanson J A. Adrenergic receptors in brain microvessels.  Trends Neurol Sci. 1983;  4 422-425
    PubMedGoogle Scholar
  • 70 Neumärker K J, Bartsch A J. Anorexia nervosa und “anorexia athletica”?. WMW 1998: 245-250
    Google Scholar
  • 71 Newsholme E A, Acworth I N, Blomstrand E. Amino acids, brain neurotransmitters and a functional link between muscle and brain that is important in sustained exercise. In: Benzi G (ed) Advances in Myochemistry. London; John Libbey Eurotext 1987: 127-133
    Google Scholar
  • 72 Newsholme E A, Blomstrand E, Hassmén P, Ekblom B. Physical and mental fatigue: do changes in plasma amino acids play a role?.  Biochem Soc Trans. 1991;  19 358-362
    PubMedGoogle Scholar
  • 73 Nicholls J G, Martin A R, Wallace B G. Vom Neuron zum Gehirn. Stuttgart; Fischer 1995: 176-203
    Google Scholar
  • 74 Nitsch J R. Die Eigenzustandsskala (EZ-Skala) - Ein Verfahren zur hierarchisch-mehrdimensionalen Befindlichkeitsskalierung. In: Nitsch JR, Udris I (eds) Beanspruchung im Sport. Bad Homburg; Limpert 1976: 81-102
    Google Scholar
  • 75 Owens M J, Nemeroff C B. Role of serotonin in the pathophysiology of depression: focus on the serotonin transporter.  Clin Chem. 1994;  40 288-295
    CrossrefPubMedGoogle Scholar
  • 76 Pannier J L, Bouckaert J J, Lefebvre R A. The antiserotonin agent pizotifen does not increase endurance performance in humans.  Eur J Appl Physiol. 1995;  72 175-178
    CrossrefPubMedGoogle Scholar
  • 77 Pletscher A. The 5-hydroxytryptamine system of blood platelets: physiology and pathophysiology.  Int J Cardiol. 1987;  14 177-188
    CrossrefPubMedGoogle Scholar
  • 78 Rudnick G, Clark H. From synapse to vesicle: the reuptake and storage of biogenic amine neurotransmitters.  Biochim Biophys Acta. 1993;  1144 249-263
    CrossrefPubMedGoogle Scholar
  • 79 Segura R, Ventura J L. Effect of L-tryptophan supplementation on exercise performance.  Int J Sports Med. 1988;  9 301-305
    PubMedGoogle Scholar
  • 80 Sheline Y l, Bardgett M E, Jackson J L, Newcomer H W, Csernansky I G. Platelet serotonin markers and depressive symptomatology.  Biol Psychiatry. 1995;  37 442-447
    CrossrefPubMedGoogle Scholar
  • 81 Sourkes T L. Toxicology of serotonin precursors.  Adv Biol Psychiat. 1983;  10 160-175
    PubMedGoogle Scholar
  • 82 Spector A A. Fatty acid binding to plasma albumin.  J Lipid Res. 1975;  16 165-179
    PubMedGoogle Scholar
  • 83 Spigset O, Mjörndal T. Serotonin 5-HT2A receptor binding in platelets from healthy subjects as studied by [3H]-lysergic acid diethylamide ([3H]-LSD): intra- and interindividual variability.  Neuropsychopharmacol. 1997;  16 285-293
    PubMedGoogle Scholar
  • 84 Stensrud T, Ingjer F, Holm H, Strømme S B. L-tryptophan supplementation does not improve running performance.  Int J Sports Med. 1992;  13 481-485
    PubMedGoogle Scholar
  • 85 Støving R K, Hangaard J, Hansen-Nord M, Hagen C. A review of endocrine changes in anorexia nervosa.  J Psychiatric Res. 1999;  33 139-152
    CrossrefPubMedGoogle Scholar
  • 86 Strachan A T, Maughan R J. Platelet serotonin transporter density and related parameters in endurance-trained and sedentary male subjects.  Acta Physiol Scand. 1998;  163 165-171
    CrossrefPubMedGoogle Scholar
  • 87 Strachan A T, Maughan R J. The hormonal response to a d-fenfluramine challenge in trained and sedentary men.  Med Sci Sports Med. 1999;  31 547-553
    PubMedGoogle Scholar
  • 88 Strüder H K. Influence of muscular work on brain metabolism and psyche in trained and untrained males of different ages. The monoaminergic and neuroendocrine system. Cologne; German Sport University Cologne 2000
    Google Scholar
  • 89 Strüder H K, Ferrauti A, Gotzmann A, Weber K, Hollmann W. Effect of carbohydrates and caffeine on plasma amino acids, neuroendocrine responses and performance in tennis.  Nutr Neurosci. 1998;  1 419-426
    PubMedGoogle Scholar
  • 90 Strüder H K, Hollmann W, Donike M, Platen P, Weber K. Effect of O2 availability on neuroendocrine variables at rest and during exercise: O2 breathing increases plasma prolactin.  Eur J Appl Physiol. 1996;  74 443-449
    CrossrefPubMedGoogle Scholar
  • 91 Strüder H K, Hollmann W, Duperly J, Weber K. Amino acid metabolism in tennis and its possible influence on the neuroendocrine system.  Br J Sp Med. 1995;  29 28-30
    PubMedGoogle Scholar
  • 92 Strüder H K, Hollmann W, Platen P, Donike M, Gotzmann A, Weber K. Influence of paroxetine, branched-chain amino acids and tyrosine on neuroendocrine system responses and fatigue in humans.  Horm Metab Res. 1998;  30 188-194
    PubMedGoogle Scholar
  • 93 Strüder H K, Hollmann W, Platen P, Duperly J, Fischer H G, Weber K. Alterations in plasma free tryptophan and large neutral amino acids do not affect perceived exertion and prolactin during 90min of treadmill exercise.  Int J Sports Med. 1996;  17 73-79
    PubMedGoogle Scholar
  • 94 Strüder H K, Hollmann W, Platen P, Rost R, Weicker H, Kirchhof O, Weber K. Neuroendocrine system and mental function in sedentary and endurance-trained elderly males.  Int J Sports Med. 1999;  20 159-166
    Article in Thieme ConnectPubMedGoogle Scholar
  • 95 Strüder H K, Hollmann W, Platen P, Wöstmann R, Donike M, Weber K. Einfluss von Paroxetin, verzweigtkettingen Aminosäuren und Tyrosin auf das endocrine System und die körperliche Leistungsfähigkeit.  Dtsch Z Sportmed. 1995;  46 458-463
    PubMedGoogle Scholar
  • 96 Strüder H, Hollmann W, Platen P, Wöstmann R, Ferrauti A, Weber K. Effects of exercise intensity on free tryptophan to branched-chain amino acids ratio and plasma prolactin during endurance exercise.  Can J Appl Physiol. 1997;  22 280-291
    PubMedGoogle Scholar
  • 97 Strüder H K, Hollmann W, Platen P, Wöstmann R, Weicker H, Molderings G H. Effect of acute and chronic exercise on plasma amino acids and prolactin concentrations and on [3H]ketanserin binding to 5-HT2A receptors on human platelets.  Eur J Appl Physiol. 1999;  79 318-324
    CrossrefPubMedGoogle Scholar
  • 98 Strüder H K, Hollmann W, Weicker H, Strobel G, Platen P, Heck H, Hartmann U, Bartmus U, Grabow V, Schulz H, Wöstmann R, Weber K. Influence of moderate and excessive endurance training on the serotonergic system.  Int J Sports Med. 1999;  20 S38
    PubMedGoogle Scholar
  • 99 Sundgot-Borgen J. Nutrient intake of female elite athletes suffering from eating disorders.  Int J Sport Nutrition. 1993;  3 431-442
    PubMedGoogle Scholar
  • 100 Sundgot-Borgen J. Eating disorders, energy intake, training volume and menstrual function in high-level modern rhythmic gymnasts.  Int J Sport Nutrition. 1996;  6 100-109
    PubMedGoogle Scholar
  • 101 Takikawa O, Kuroiwa T, Yamazahki F, Kido R. Function and regulation of extrahepatic tryptophan pyrrolase (indoleamine 2,3-dioxygenase): studies of its induction by interferon-γ. In: Bender DA, Joseph MH, Kochen W, Steinhart H (eds) Progress in tryptophan and serotonin research 1986. Berlin; De Gruyter 1987: 47-52
    Google Scholar
  • 102 Urhausen A, Kindermann W. Current markers for the diagnosis of overtraining in sports practice.  Int J Sports Med. 1999;  20 S54
    PubMedGoogle Scholar
  • 103 Van Hall G, Raaymakers J SH, Saris W HM, Wagenmakers A JM. Ingestion of branched-chain amino acids and tryptophan during sustained exercise in man: failure to affect performance.  J Physiol. 1995;  486 789-794
    PubMedGoogle Scholar
  • 104 Van Wersch J WJ, Kaiser V, Janssen G ME. Platelet system changes associated with a training period of 18 - 20 months: a transverse and a longitudinal approach.  Int J Sports Med. 1989;  10 S181-S185
    PubMedGoogle Scholar
  • 105 Varnier M, Sarto P, Martines D, Lora L, Carmignoto F, Leese G P, Naccarato R. Effect of infusing branched-chain amino acid during incremental exercise with reduced muscle glycogen content.  Eur J Appl Physiol. 1994;  69 26-31
    CrossrefPubMedGoogle Scholar
  • 106 Verger P, Aymard P, Cynobert L, Anton G, Luigi R. Effects of administration of branched-chain amino acids vs glucose during acute exercise in the rat.  Physiol Behav. 1994;  55 523-526
    CrossrefPubMedGoogle Scholar
  • 107 Weicker H, Strobel G. Sportmedizin - biochemisch-physiologische Grundlagen und ihre sportartspezifische Bedeutung. Stuttgart, Jena, New York; Fischer 1994
    Google Scholar
  • 108 Wilson W M, Maughan R J. Evidence for a possible role of 5-hydroxytryptamine in the genesis of fatigue in man: administration of paroxetine, a 5-HT re-uptake inhibitor, reduces the capacity to perform prolonged exercise.  Exp Physiol. 1992;  77 921-924
    CrossrefPubMedGoogle Scholar

PD Dr. H. K. Strüder

Institute of Theory and Practice of Training and Movement
German Sport University

Carl-Diem-Weg 6
50933 Cologne
Germany


Phone: +49 (221) 4995818

Fax: +49 (221) 4995818

Email: strueder@hrz.dshs-koeln.de

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