Int J Sports Med 2001; 22(8): 558-565
DOI: 10.1055/s-2001-18526
Physiology and Biochemistry
© Georg Thieme Verlag Stuttgart · New York

The Circulatory Response to Exercise: Role of the Peripheral Pump

T. W. Rowland
  • Department of Pediatrics, Baystate Medical Center, Springfield, MA, USA
Further Information

Publication History

Publication Date:
20 November 2001 (online)

The circulation of blood during upright exercise involves a two-pump system, a central cardiac pump and a peripheral pump responsible for systemic venous return. Axiomatically, the function of the two pumps must be equal, and certain evidence suggests that the peripheral pump may “drive” the circulation during exercise. Despite its potential importance to circulatory reserve and aerobic fitness, little is known regarding the determinants of the peripheral pump. Pumping function of skeletal muscle and the suction effect of the left ventricle presumably are principal factors in defining systemic venous return. This review, which focuses on data in humans, examines current information regarding the peripheral pump and its potential role as a critical determinant of maximal cardiac output, maximal oxygen uptake, and endurance fitness.

References

  • 1 Agostini P, Butler J. Cardiopuimonary interactions in exercise. In: Whipp BJ, Wasserman K (eds) Exercise: Pulmonary Physiology and Pathophysiology. New York; Marcet Dekker Inc. 1991: 221-252
  • 2 Barcroft H, Dornhorst A C. Demonstration of the “muscle pump” in the human leg.  J Physiol. 1948;  108 39P
  • 3 Barendsen G J, van den Berg  JW. Venous capacity venous refill time and the effectivess of the calf muscle pump in normal subjects.  Angiology. 1984;  35 163-184
  • 4 Bassett D R, Howley E T. Limiting factors for maximum oxygen uptake and determinants of endurance performance.  Med Sci Sports Exerc. 2000;  32 70-84
  • 5 Berger R A. Applied Exercise Physiology. Philadelphia; Lea & Febiger 1982: 205-237
  • 6 Bevegard S, Lodin A. Postural circulatory changes at rest and during exercise in five patients with congenital absence of valves in the deep veins of the legs.  Acta Med Scand. 1962;  172 21-29
  • 7 Bevegard B S, Shepherd J T. Regulation of the circulation during exercise in man.  Physiol Rev. 1967;  47 178-213
  • 8 Braunwald E, Sarnoff S J, Stansby W N. Determinants of duration and mean rate of ventricular ejection.  Circ Res. 1958;  6 319-325
  • 9 Carroll J D, Hess O M, Hirzel H O, Krayenbuehl H P. Dynamics of left ventricular filling at rest and during exercise.  Circulation. 1983;  68 59-67
  • 10 Cheng C P, Igarashi Y, Little W C. Mechanism of augmented rate of left ventricular filling during exercise.  Circ Res. 1992;  70 9-19
  • 11 Courtois M, Ludbrook P A. Intraventricular pressure transients during relaxation and filling. In: Gaasch WH, LeWinter MM (eds) Left Ventricular Diastolic Dysfunction and Heart Failure. Philadelphia; Lea & Febiger 1994: 150-166
  • 12 DiBello V, Santoro G, Talarico L, DiMuro C, Caputo M T, Girogo D, Bertini A, Bianchi M, Giusti C. Left ventricular function during exercise in athletes and in sedentary men.  Med Sci Sports Exerc. 1996;  28 190-196
  • 13 Folkow B, Gaskell P, Waaler B A. Blood flow through limb muscles during heavy rhythmic exercise.  Acta Physiol Scand. 1970;  80 61-72
  • 14 Folkow B, Haglund U, Jodal M, Lundgren O. Blood flow in the calf muscle of man during heavy rhythmic exercise.  Acta Physiol Scand. 1971;  81 157-163
  • 15 Gledhill N, Cox D, Jamnik R. Endurance athletes’ stroke volume does not plateau: major advantage is diastolic function.  Med Sci Sports Exerc. 1994;  26 1116-1121
  • 16 Gotshall R W, Bauer T A, Fahrner S L. Cycling cadence alters exercise hemodynamics.  Int J Sports Med. 1996;  17 17-21
  • 17 Guyton A C. Determination of cardiac output by equating venous return curves with cardiac response curves.  Physio Rev. 1955;  35 123-129
  • 18 Guyton A C, Douglas B H, Langston J B, Richardson T Q. Instantaneous increase in mean circulatory pressure and cardiac output at onset of muscular activity.  Circ Res. 1962;  11 431-441
  • 19 Hamada T, Sale D G, MacDougall J D. Postactivation potentiation in endurance-trained male athletes.  Med Sci Sports Exerc. 2000;  32 403-411
  • 20 Harms C A, Wetter T J, McClaran S R, Pegelow D F, Nickele G A, Nelson W B, Hanson P, Dempsey J A. Effects of respiratory muscle work on cardiac output and its distribution during maximal exercise.  J Appl Physiol. 1998;  85 609-618
  • 21 Higginbotham M B, Morris K G, Williams R S, McHale P A, Coleman R E, Cobb F R. Regulation of stroke volume during submaximal and maximal upright exercise in normal.  Cir Res. 1986;  58 281-291
  • 22 Hilsted J, Parving H H, Christensen N J, Benn J, Galbo H. Hemodynamics in diabetic orthostatic hypotension.  J Clin Invest. 1981;  68 1427-1434
  • 23 Hughson R L, Tschakovsky M E. Cardiovascular dynamics at the onset of exercise.  Med Sci Sports Exerc. 1999;  31 1005-1010
  • 24 Janicki J S, Sheriff D D, Robotham J L, Wise R A. Cardiac output during exercise: contributions of the cardiac, circulatory, and respiratory systems. In: Rowell RB, Shepherd JT (eds) Handbook of Physiology. Exercise: Regulation and Integration of Multiple Systems. Bethesda MD; American Physiological Society 1996: 649-704
  • 25 Key J D, Keys T G, Callahan J A. Historical development of concept of blood circulation.  Am J Cardiol. 1979;  43 1026-1032
  • 26 Laughlin M H. Skeletal muscle blood flow capacity role of muscle pump in exercise hyperemia.  Am J Physiol. 1987;  253 H993-H1004
  • 27 Laughlin M H, Schrage W G. Effects of muscle contraction on skeletal muscle blood flow: when is there a muscle pump?.  Med Sci Sports Exerc. 1999;  31 1027-1035
  • 28 Libonati J R. Exercise training improves left ventricular isovolumic relaxation.  Med Sci Sports Exerc. 2000;  32 1399-1405
  • 29 Libonati J R. Exercise and myocardial diastolic function.  Med Sci Sports Exerc. 1999;  31 1741-1747
  • 30 Linden R J. The size of the heart.  Cardioscience. 1994;  5 225-233
  • 31 Nielsen H V. Effect of vein pump activation upon muscle blood flow and venous pressure in the human leg.  Acta Physiol Scand. 1982;  114 481-485
  • 32 Notarius C F, Magder S. Central venous pressure during exercise: role of muscle pump.  Can J Physiol Pharmacol. 1996;  74 647-651
  • 33 Paavolainen L M, Nummela A T, Rusko H K. Neuromuscular characteristics and muscle power as determinants of 5 km running performance.  Med Sci Sports Exerc. 1999;  31 124-130
  • 34 Pollack A A, Wood E H. Venous pressure in the saphenous vein at the ankle in man during exercise and changes in posture.  J Appl Physiol. 1949;  1 649-662
  • 35 Reeves J T, Groves B M, Cymerman A, Sutton J R, Wagner P D, Turkevich D, Houston C S. Operation Everest II: Cardiac filling pressures during cycle exercise at sea level.  Resp Physiol. 1990;  80 47-154
  • 36 Rowell L B, O’Leary D S, Kellogg D L. Integration of cardivascular control systems in dynamic exercise. In: Rowell LB, Shepherd JT (eds) Handbook of Physiology. Regulation and Integration of Multiple Systems. Bethesda, MD; American Physiological Society 1996: 778-781
  • 37 Rowland T W. Cardiovascular function. In: Armstrong N, van Mechelen W (eds) Paediatric Exercise Science and Medicine. Oxford; Oxford University Press 2000: 163-172
  • 38 Rowland T, Blum J W. Cardiac dynamics during upright cycle exercise in boys.  Am J Hum Biol. 2000;  12 749-757
  • 39 Rowland T, Mannie E, Gawle  L. Dynamics of left ventricular diastolic filling during exercise: A Doppler echocardiographic study of 10 - 14 year old boys (abstract).  Ped Exerc Sci. 2001;  13 181-187
  • 40 Rowland T, Potts J, Potts T, Sandor G, Goff D, Ferrone L. Cardiac responses to progressive exercise in normal children: a synthesis.  Med Sci Sports Exerc. 2000;  32 255-259
  • 41 Senior D G, Waters K L, Cassidy M, Crucitti T, Shapiro H, Riba A L. Effect of aerobic training on left ventricular diastolic filling.  Conn Med. 1989;  53 67-70
  • 42 Sheriff D D, Powell L B, Scher A M. Is rapid rise in vascular conductance at onset of dynamic exercise due to muscle pump?.  Am J Physiol. 1993;  265 H1227-H1234
  • 43 Stegall H F. Muscle pumping in the dependent leg.  Circ Res. 1966;  19 180-190
  • 44 Stick C, Jaeger H, Witzleb E. Measurements of volume changes and venous pressure in the human lower leg during walking and running.  J Appl Physiol. 1992;  72 2063-2068
  • 45 Tschakovsky M E, Shoemaker J K, Hughson R L. Vasodilation and muscle pump contribution to immediate exercise hyperemia.  Am J Physiol. 1996;  271 H1697-H1701
  • 46 Udelson J F, Bacharach S L, Cannon P O, Bonow R O. Minimum left ventricular pressure during B-adrenergic stimulation in human subjects.  Circulation. 1990;  82 1174-1182
  • 47 Van Overschelde J J, Essamri B, van Butsele R, D’Hondt A M, Cosyns J R, Detry J M, Melin J A. Contribution of left ventricular diastolic function to exercise capacity in normal subjects.  J Appl Physiol. 1993;  74 2225-2233
  • 48 Walloe L, Wesche J. Time course and magnitude of blood flow changes in the human quadriceps muscles during and following rhythmic exercise.  J Physiol. 1988;  405 257-273
  • 49 Wexler L D, Bergel D H, Gabe I T, Makin G S, Mills C J. Velocity of blood flow in normal human venae cavae.  Circ Res. 1968;  23 349-359
  • 50 Yellin E L, Nikolic S D. Diastolic suction and the dynamics of left ventricular filling. In: Gaasch WH, LeWinter MM (eds) Left Ventricular Diastolic Dysfunction and Heart Failure. Philadelphia; Lea & Febiger 1994: 89-102

T. W. Rowland, M. D.

Department of Pediatrics
Baystate Medical Center

Springfield, MA 01199
USA


Phone: +01(413) 794 7350

Fax: +01(413) 794 3623

    >