Horm Metab Res 2001; 33(11): 687-688
DOI: 10.1055/s-2001-18685
Short Communication
© Georg Thieme Verlag Stuttgart · New York

Long-Term Correction of Hyperglycaemia in Streptozotocin-Induced Diabetic Rats Transplanted with Islets Placed in an Implantation Device

E. Olivares 1 , S. Piranda 2 , W. J. Malaisse 1
  • 1 Laboratory of Experimental Medicine, Brussels Free University, Brussels, Belgium
  • 2 Statice Santé, Besançon, France
Further Information

Publication History

Publication Date:
04 December 2001 (online)

Introduction

Pancreatic islet xenotransplantation might conceivably be successfully achieved if the islets are placed in a device protecting them against immune rejection [1]. We were interested in taking a first step in exploring this possibility using a rat model. The present study was aimed at monitoring the changes in body weight and glycemia occurring in streptozotocin-induced diabetic rats (STZ rats) transplanted with xenografted islets. Islets were prepared from animals of the same species and strain and placed in an implantation device with selectively permeable membranes.

References

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Prof. W. J. Malaisse

Laboratory of Experimental Medicine
Brussels Free University

808 Route de Lennik
1070 Brussels, Belgium


Phone: + 32 (2) 55 56 238

Fax: + 32 (2) 55 56 239

Email: [email protected]