Employment of MARS (Molecular Adsorbent Recycling System) for replacement of liver detoxification function up to orthotopic liver transplantation

We report the case of a 30-year-old male patient, who was referred to our department because of acute liver failure with underlying chronic alcohol abuse. No recompensation of liver-function was achieved by means of conservative treatment and the patient was listed for orthotopic liver transplantation. Because of clinically severe encephalopathy and progressive hyperbilirubinemia intermittent extracorporal detoxification with Molecular Adsorbent Recycling System (MARS) was initiated. After application of MARS-therapy distinct decrease of bilirubin and prompt improvement of hepatic encephalopathy up to adequate response of the patient occurred. The liver synthesis capacity did not change during MARS-therapy. Through MARS 48 days could be bridged successfully until a transplant was available. The patient was transplanted in a physical and neurological good condition without complications.

Correspondence