Facial plast Surg 2002; 18(1): 013-026
DOI: 10.1055/s-2002-19823
Copyright © 2002 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

Bone Healing and Bone Substitutes

Peter D. Costantino1, 2 , David Hiltzik1 , Satish Govindaraj1 , Jason Moche1
  • 1Department of Otolaryngology, Mount Sinai Medical Center, New York, NY
  • 2Center for Cranial Skull Base Surgery, St. Luke's-Roosevelt Hospital Center, New York, NY
Further Information

Publication History

Publication Date:
29 January 2002 (online)


With the advent of new biomaterials and surgical techniques, the reconstructive surgeon has a wider range of treatment modalities for the rehabilitation and reconstruction of craniofacial skeletal deformities than ever before. These innovative substances act as true bone graft substitutes, thereby allowing the surgeon to avoid the use of autogenous bone grafts and their associated donor site morbidity. Surgeons have long been interested in producing a composite graft that can heal faster by induction, incorporate with surrounding tissues, and be remodeled to resemble native bone. Currently, there are a host of bone graft substitutes available that vary in both their composition and properties. Craniomaxillofacial surgeons must therefore become comfortable with numerous biomaterials to best tailor the treatment for each patient individually. Ongoing investigations into the next phase of tissue engineering will continue to bring us closer to the ability to regenerate or replace bone.