Resistance of Succinic Acid Dimethyl Ester Insulinotropic Action to Exendin (9-39) Amide

Abstract

Exendin (9-39) amide (Ex [9-39]) was recently proposed for use in the treatment of alimentary or reactive hypoglycaemia. It was indeed found to antagonise the insulinotropic action of GLP-1 in rats infused with the dimethyl ester of succinic acid (SAD). We have now investigated whether, under comparable experimental conditions, Ex (9-39) also opposes the insulin-releasing action of SAD itself. Since this was not the case, Ex (9-39) could be safely used to abolish the incretin effect of GLP-1 without interfering with the control of insulin secretion by circulating nutrients.

Key words

Exendin (9-39) Amide - Succinic Acid Dimethyl Ester - Insulin Secretion - Anaesthetized Rats

References

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