Morbus Sudeck - Pathophysiologie und Therapie eines komplexen Schmerzsyndroms

Zusammenfassung: Der "Morbus Sudeck", heute Komplexes Regionales Schmerzsyndrom (CRPS) genannt, ist gekennzeichnet durch eine Symptomentrias motorischer, sensibler und autonomer Störungen. Seine klinische Symptomatik ist charakterisiert durch Spontanschmerz und Hyperalgesie, die nicht auf ein Nervenversorgungsgebiet beschränkt bleiben und dem auslösenden Ereignis nicht angemessen sind. Die Pathophysiologie dieser Erkrankung ist noch immer nicht endgültig geklärt, der Großteil therapeutischer Möglichkeiten ist noch immer rein symptomatisch. Der momentane Stand der Forschung zum CRPS ermöglicht jedoch bereits mehr Einblicke in die Grundlagen der Krankheit als noch vor wenigen Jahren und ermöglicht auch Anfänge einer pathophysiologisch orientierten Therapie.

Sudeck`s atrophy: pathophysiology and treatment of a complex pain syndrome

Summary: The "Morbus Sudeck" or Complex Regional Pain Syndrome (CRPS) forms a typical triad of motor, sensory and autonomic symptoms. It is clinically characterized by spontaneous pain and hyperalgesia not limited to a single nerve territory and disproportionate to the inciting event. An underlying pathophysiology which could explain the whole symptomatology of CRPS is still unknown. Therefore, nowadays therapy is still symptomatic. However, recent research led to a better understanding of the disease and to the beginning of a pathophysiologically orientated therapy.

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