Zusammenfassung
Östrogene spielen eine zentrale Rolle in der Regulation der Physiologie von Brustdrüsengewebe
und Endometrium. Darüber hinaus kommt ihnen eine entscheidende Bedeutung in der Entstehung
und Progression von Malignomen dieser Gewebe zu. Östrogene vermitteln ihre Wirkung
über verschiedene Östrogenrezeptor-Isoformen und -Isotypen. So überwiegt im Brustdrüsengewebe
und im Endometrium die Expression des klassischen ERα, während im Ovar überwiegend
der alternative ERβ exprimiert wird. Diese Übersicht fasst kurz die Struktur, Funktion
und Expression dieser Rezeptoren unter besonderer Berücksichtigung des Endometriumkarzinoms
zusammen. Erste Ergebnisse deuten darauf, dass eine Verschiebung des physiologischen
ERα/ERβ-Verhältnisses in Endometriumkarzinomen mit einer schlechten klinischen Prognose
korreliert. Darüber hinaus wird die klinische Relevanz der differenziellen Östrogenrezeptorexpression
im Hinblick auf eine Antihormontherapie dargestellt.
Summary
Estrogens play a crucial role in the regulation of the physiology of breast tissue
and endometrium. Furthermore, estrogen has been implicated in the initiation and progression
of neoplasms of these tissues. Estrogens mediate their effects through various estrogen
receptor isoforms and isotypes. In breast tissue and in the endometrium the classical
estrogen receptor ERα represents the mainly expressed ER isoform, whereas in the ovary
the alternative estrogen receptor ERβ is predominantly expressed. This review briefly
describes the structure, function and expression of these receptors with special regard
to endometrial cancer. Recent data indicate that alterations of the physiological
ERα/ERβ ratio in endometrial cancer correlates with poor clinical outcome. The potential
clinical relevance of differential ER-isotype expression is also discussed with respect
to an antihormonal therapy.
Schlüsselwörter
Östrogenrezeptor - Endometrium - Karzinom
Key words
Estrogen receptor - Endometrium - Carcinoma
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Dr. Bettina Hanstein
Universitäts-Frauenklinik Düsseldorf
Moorenstr. 5
D-40225 Düsseldorf
Phone: +49-2 11-8 11 75 01
Fax: +49-2 11-8 11 81 47
Email: Bettina.Hanstein@uni-duesseldorf.de