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Horm Metab Res 2002; 34(2): 55-61
DOI: 10.1055/s-2002-20525
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© Georg Thieme Verlag Stuttgart · New York

Central 5-HT3 Receptor Stimulation by m-CPBG Increases Blood Glucose in Rats

F.  Carvalho 1 , D.  Macêdo 1 , I.  Bandeira 1 , I.  Maldonado 1 , L.  Salles 1 , M.  F.  Azevedo 1 , M.  A.  Rocha Jr. 1 , J.  B.  Fregoneze 2 , E.  De Castro-e-Silva 1
  • 1 Department of Physiology, Health Sciences Institute, Federal University of Bahia, Brazil
  • 2 Department of Zoology, Biology Institute, Federal University of Bahia, Brazil
Further Information

Publication History

9 January 2001

24 September 2001

Publication Date:
04 March 2002 (online)

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Abstract

The aim of the present study was to investigate the role of central 5-HT3 receptors on the control of blood glucose in stressed and non-stressed rats in both fasted and fed states. Adult Wistar male rats had each their third ventricle cannulated 7 days before the experiments. Injections of m-CPBG, a selective 5-HT3 receptor agonist, induced a significant increase in blood glucose in non-stressed rats in both fasted and in fed states. The same procedure was unable to modify stress-induced hyperglycemia. The hyperglycemic effect of m-CPBG central administration was blocked by pretreatment with ondansetron, a specific 5-HT3 receptor antagonist, indicating that the effects here obtained with m-CPBG were a result of its interaction with 5-HT3 receptors. Third ventricle injections of ondansetron alone were not able to modify blood glucose in non-stressed animals and did not change the hyperglycemic responses observed after immobilization stress. We conclude that pharmacological activation of the central 5-HT3 receptor induces a hyperglycemic effect in non-stressed animals.

Key words

Serotonin - Stress - Blood Glucose - Hyperglycemia - 5-HT3 Receptor

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Emilio  de Castro e Silva, M.D., Ph.D.

Universidade Federal da Bahia · Institute de Ciências da Saúde · Departamento de Fisiologia

40110-100 Salvador - BA · Brasil

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