Subscribe to RSS
© Georg Thieme Verlag Stuttgart · New York
Magnetic Resonance Female Breast Imaging (MRFBI)Evaluation of the Changes in Signal Intensity over Time Pre- and Post-administration of 0.2 mmol/kg Gd-DTPAMagnetresonanztomographie der BrustEvaluation der zeitabhängigen Signalveränderung vor und nach Administration von 0,2 mmol/kg Gd-DTPA
04 April 2002 (online)
Purpose: We are looking for a threshold value to discriminate between benign and malign breast lesions in MRI of female breast after administration of 0.2 mmol Gadolinum-DTPA/kg bw.
Materials and Methods: Double coil breast MRI (1.5 Tesla) were performed in 65 patients with an suspicious lesion for malignancy in an anteriorly examination. 57 patients could be evaluated in our study design. Histopathological 35 patients had an invasive carcinoma, 3 patients had an in-situ-carcinoma and in 27 patients benign changes were found.
Results: For different carcinoma diameters we found a different increase of signal intensity (SI): small carcinoma (< 10 mm) had an maximum increase of SI of 102 %, medium sized (10 to 20 mm) 222 % and carcinomas over 20 mm showed an increase of 271 %. We did not find a significant difference between SI in benign and malign lesions. The sensitivity was 94.6 % the specificity 65 %.
Conclusion: A threshold value to distinguish between malign and benign in MRI could not be defined. With the double normal Gd-DTPA dose we do not have better specificity and sensitivity than for normal dose (0.1 mmol/kg bw) is described.
Breast Neoplasms - Magnetic Resonance Imaging - Contrast Media - Gadolinium DTPA - Sensitivity and Specificity
- 1 Heywang-Köbrunner S H, Haustein J, Pohl C, Beck R, Lommatzsch B, Untch M, Nathrath W B. Contrast-enhanced MR imaging of the breast: comparison of two different doses of gadopentetate dimeglumine. Radiology. 1994; 191 639-646
- 2 Kaiser W A. Dynamic magnetic resonance breast imaging using a double breast coil: An important step toward routine examination of the breast. Front Eur Radiol. 1990; 7 39-68
- 3 Heywang-Köbrunner S H. Contrast-enhanced magnetic resonance imaging of the breast. Invest Radiol. 1994; 29 94-104
- 4 Kaiser W A, Zeitler E. MR-imaging of the breast: fast imaging sequences with and without Gd-DTPA. Radiology. 1989; 170 681-686
- 5 Harms S E, Flaming D P, Hesley K L. et al . MR imaging of the breast with rotating delivery of excitation off resonance: clinical experience with pathologic correlation. Radiology. 1993; 187 493-501
- 6 Orel S G, Schnall M D, LiVolsi V A. et al . Suspicious breast lesions: MR imaging with radiologic-pathologic correlation. Radiology. 1994; 190 121
- 7 Mus R D, Boetes C, Holland R, Guijt W, Karssemeijer N, Barentsz J O. One-minute, single-section dynamic MR mammography with color-coded time, slope, and maximum signal intensity images: prelude to MR breast screening. Radiology. 1994; 193 121
- 8 Gribbestad I S, Nilsen G, Fjøsne H, Kvinnsland S, Haugen O A, Rinck P A. Comparative signal intensity measurements in dynamic gadolinium-enhanced MR mammography. JMRI. 1994; 4 477-480
- 9 Turkat T J, Klein B D, Polan R L, Richman R H. Dynamic MR mammography: a technique for potentially reducing the biopsy rate for benign breast disease. JMRI. 1990; 4 563-568
- 10 Flickinger F W, Allison J D, Sherry R M, Wright J C. Differentiation of benign from malignant breast masses by time-intensity evaluation of contrast enhanced MRI. Magn Reson Imaging. 1993; 11 617-620
- 11 Gilles R, Guinebretière J M. et al . Nonpalpable Breast Tumors: Diagnosis with contrast-enhanced subtraction dynamic MR imaging. Radiology. 1994; 191 625-631
- 12 Stalling C B, Hazle J D. MR imagining of the breast. A categorical course in breast imaging. Radiological Society of North America 1995; 185-197
- 13 Kaiser W A. Magnetresonanztomographie der Mamma, Erfahrungen nach 253 Untersuchungen. DMW. 1989; 114 1351-1357
- 14 Kaiser W A. Moderne Diagnostik der Mamma. Geburtsh Frauenheilkd. 1993; 53 1-14
- 15 Stomper P C, Winston J S, Herman S, Klippenstein D L, Arredondo M A, Blumenson L E. Angiogenesis and dynamic MR imaging gadolinium enhancement of malignant and benign breast lesions. Breast Cancer Res Treat. 1997; 45(1) 39-46
- 16 Buadu L D, Murakami J, Murayama S, Hashiguchi N, Sakai S, Masuda K, Toyoshima S, Kuroki S, Ohno S. Breast lesions: correlation of contrast medium enhancement patterns on MR images with histopathologic findings and tumor angiogenesis. Radiology. 1996; 100 639-649
- 17 Gribbestad I S, Nilsen G, Fjøsne H, Fougner R, Haugen O A, Petersen S B, Rinck P A, Kvinnland S. Contrast-enhanced magnetic resonance imaging of the breast. Acta Oncol.. 1992; 31 833-842
Dr. med. Peter Kohlschein
University of Rostock, Medical Faculty
Institute of Clinical Chemistry and Pathobiochemistry