Zentralbl Gynakol 2002; 124(2): 104-110
DOI: 10.1055/s-2002-24233

© Georg Thieme Verlag Stuttgart · New York

Magnetic Resonance Female Breast Imaging (MRFBI)

Evaluation of the Changes in Signal Intensity over Time Pre- and Post-administration of 0.2 mmol/kg Gd-DTPAMagnetresonanztomographie der BrustEvaluation der zeitabhängigen Signalveränderung vor und nach Administration von 0,2 mmol/kg Gd-DTPAH. Schedel1 , H. Oellinger1 , P. Kohlschein2 , C. Siewert1 , J. Hadijuana1 , J. U. Blohmer3 , T. Kissner3 , R. Felix1
  • 1Department of Radiology, Charité, Campus Virchow Wedding, Humboldt-University, Medical Faculty, Augustenburger Platz 1, D-13353 Berlin
  • 2Institute of Clinical Chemistry and Pathobiochemistry, University of Rostock, Medical Faculty, Ernst Heydemann-Straße 6, D-18057 Rostock
  • 3Department of Obstetrics and Gynecology, Charité, Campus Charité Mitte, Humboldt-University Berlin, Medical Faculty, Schumannstraße 20/21, D-10117 Berlin
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04. April 2002 (online)


Purpose: We are looking for a threshold value to discriminate between benign and malign breast lesions in MRI of female breast after administration of 0.2 mmol Gadolinum-DTPA/kg bw.
Materials and Methods: Double coil breast MRI (1.5 Tesla) were performed in 65 patients with an suspicious lesion for malignancy in an anteriorly examination. 57 patients could be evaluated in our study design. Histopathological 35 patients had an invasive carcinoma, 3 patients had an in-situ-carcinoma and in 27 patients benign changes were found.
Results: For different carcinoma diameters we found a different increase of signal intensity (SI): small carcinoma (< 10 mm) had an maximum increase of SI of 102 %, medium sized (10 to 20 mm) 222 % and carcinomas over 20 mm showed an increase of 271 %. We did not find a significant difference between SI in benign and malign lesions. The sensitivity was 94.6 % the specificity 65 %.
Conclusion: A threshold value to distinguish between malign and benign in MRI could not be defined. With the double normal Gd-DTPA dose we do not have better specificity and sensitivity than for normal dose (0.1 mmol/kg bw) is described.


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Dr. med. Peter Kohlschein

University of Rostock, Medical Faculty

Institute of Clinical Chemistry and Pathobiochemistry

Ernst-Heydemann-Straße 6

18057 Rostock

Telefon: +49/381/494-7595

Fax: +49/381/494-7672

eMail: peter.kohlschein@med.uni-rostock.de