A Rapid Entry to Natural and Unnatural Disubstituted Maleic Anhydrides

Abstract

Copper-mediated tandem vicinal difunctionalisation of dimethyl acetylenedicarboxylate, followed in selected cases by oxidation of one of the substituents, provides a versatile and rapid route to a variety of natural and unnatural disubstituted maleic anhydrides.

conjugate additions - copper - maleic anhydrides - natural products - tandem reactions

References

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New address: R. J. Cox, Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, USA.

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