Acute Effects of Valsartan on Insulin Sensitivity in Obese, Non-Hypertensive Subjects with and without Type 2 Diabetes

Abstract

Background: Two studies were designed to determine whether a single dose (80 mg) of the angiotensin II receptor blocker (ARB), valsartan, alters insulin sensitivity in obese, non-hypertensive subjects with and without Type 2 diabetes. Methods: Insulin sensitivity (S_I), glucose effectiveness (S_G), and acute insulin response (AIR_{0 - 10 min}) were measured by means of a 3-hour insulin-modified frequently sampled intravenous glucose tolerance test (FSIVGTT) before and after a single dose of valsartan. Study 1: obese, normotensive non-diabetic male subjects (n = 12), mean (SD) age 37.2 ± 11.2 years, BMI 32.8 ± 6.8 kg/m²; Study 2: obese, normotensive Type 2 diabetic patients (n = 12), mean age 55.7 ± 6.9 years, BMI 35.0 ± 6.8 kg/m²/l. Both studies were randomised, double-blind, placebo-controlled, single-dose crossover group studies involving subjects in two study days, two weeks apart. After fasting samples were taken, a 300 mg/kg iv glucose bolus was injected at 0 min, and 0.05 U/kg iv insulin was given 20 min later. Blood samples for analysis of glucose and insulin were taken throughout the 3-hour study period. Results: Study 1 (non-diabetic subjects) S_I 2.81 vs. 2.63 × 10^-4 min^-1 per µU/ml (p = 0.54), S_G 0.020 vs. 0.020 min^-1 (p = 0.90), AIR_{0 - 10 min} 3305 vs. 3450 µU/min/ml (p = 0.71); Study 2 (patients with type 2 diabetes) S_I 0.59 vs. 0.85 × 10^-4 min^-1 per µU/ml (p = 0.15), S_G 0.013 vs. 0.014 min^-1 (p = 0.71), AIR_{0 - 10 min} 65 vs. 119 µU/min/ml (p = 0.14), placebo vs. valsartan, respectively. Conclusion: In obese, non-hypertensive non-diabetic and Type 2 diabetic subjects a single dose of valsartan does not alter insulin sensitivity.

Key words

Valsartan - Insulin Sensitivity - Healthy Subjects - Type 2 Diabetes

References

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