Metabolic and Hemodynamic Responses to Exercise in Subcutaneous   Adipose Tissue and Skeletal Muscle

M. Boschmann; M. Rosenbaum; R. L. Leibel; K. R. Segal

doi:10.1055/s-2002-35527

International Journal of Sports Medicine, Table of Contents

Int J Sports Med 2002; 23(8): 537-543
DOI: 10.1055/s-2002-35527

Physiology & Biochemistry

Metabolic and Hemodynamic Responses to Exercise in Subcutaneous Adipose Tissue and Skeletal Muscle

M. Boschmann¹ , M. Rosenbaum^1, ² , R. L. Leibel^1, ² , K. R. Segal³

¹Laboratory of Human Behavior and Metabolism, The Rockefeller University, New York, USA
²Division of Molecular Genetics, Department of Pediatrics, Columbia University, New York, USA
³Department of Pediatrics, Cornell University Medical College, New York, USA

Abstract

This study evaluated the effect of standardized bicycle exercise on metabolism and blood flow in abdominal (aSAT) and femoral subcutaneous adipose tissue (fSAT) and skeletal muscle in eleven women and nine men. Using microdialysis, the respective tissues were perfused with Ringer's solution (+ 50 mM ethanol) and dialysate [ethanol], [glycerol], [lactate] and [pyruvate] were measured in order to estimate blood flow (ethanol dilution technique), lipolysis and glycolysis, respectively. At rest, blood flow tended to be higher in the respective tissues of women when compared to men. During exercise, blood flow was increased significantly in fSAT and muscle, but not in aSAT. Dialysate [glycerol] was increased two- to three-fold in aSAT and fSAT, similarly in men and women. However, in muscle, dialysate [glycerol] was increased five-fold in women and four-fold in men without reaching a steady state in women. Corrected for blood flow, the increase in lipolysis was greater in muscle than in fSAT, and greater in fSAT than in aSAT, and in muscle the increase was greater for women compared with men. Dialysate [lactate] and [lactate]/[pyruvate] ratio were much more increased in muscle compared with aSAT and fSAT. It is concluded that lipids stored in muscle are rather used than lipids stored in adipose tissue for fueling the energy metabolism of muscle during exercise. During exercise, lipid mobilization is much greater in women than in men.

Key words

Blood flow - glycerol - lactate - pyruvate - microdialysis

Full Text

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Dr. M. Boschmann

German Institute of Human Nutrition · Dept. Biochemistry & Physiology of Nutrition

Arthur-Scheunert-Allee 114-116 · 14558 Bergholz-Rehbrücke · Germany ·

Phone: +49 (33200) 88-430

Fax: +49 (33200) 88-500

Email: boschman@www.dife.de