Primäre und sekundäre Neoplasien des Skeletts

Zusammenfassung

Für Staging und Restaging von primären und sekundären (malignen) Neoplasien des Skeletts stellt die Skelettszintigraphie nach wie vor ein valides Verfahren dar. Sie findet sich dabei aber in einer strengen Kosten/Nutzen-Diskussion und in Konkurrenz zu insbesondere MRT und, z. B. beim Prostatakarzinom, zu Tumormarkern als Verlaufsparameter (z. B. PSA). Obwohl für die Darstellung von Knochenmetastasen zahlenmäßig die Knochenmarkszintigraphie sensitiver (läsionsbezogen) als die Skelettszintigraphie ist, hat sie sich routinemäßig nicht durchgesetzt. Der klinische Stellenwert der F-18-Fluorid-PET ist noch nicht vollständig geklärt. Die Positivdarstellung von Metastasen im Skelett ist mit weiteren Radiopharmaka möglich, z. B. „unspezifisch” mit F-18-FDG oder „spezifisch (z. B. neuroendokrine Tumoren) mit I-123-MIBG.

Abstract

Bone scintigraphy is still a valid procedure for staging and restaging of primary and secondary malignancies of the skeleton. However, there is a strong discussion about cost-effectiveness and, especially, with competing procedures like magnetic resonance imaging, and, e. g. for prostate cancer, with tumor markers like PSA. Although bone marrow scintigraphy is more sensitive for the detection of bone metastases (on a lesion by lesion basis) than bone scintigraphy, it is routinely not the procedure of choice. The clinical value of F-18-Fluoride PET is not fully clarified yet. The direct imaging of bone metastases in positive contrast is possible with a number of substances, nonspecific with F-18-FDG or more specific (e. g. neuroendocrine tumors) with I-123-MIBG.

Schlüsselwörter

Knochentumor - Knochenneoplasie - Szintigraphie

Key words

Bone tumor - scintigraphy

Literatur

• 1 Adalet I, Ozger H, Cantez S. Comparison of Tc-99m MIBI and Tl-201 uptake in musculoskeletal lesions.  Clin Nucl Med. 1996;  21 118-121
• 2 Adams S, Hovy L, Baum R P. et al . Intraoperative Metastasenlokalisation mit einer handgeführten Gammasonde.  Nuklearmedizin. 1995;  34 161-164
• 3 Ady N, Zucker J M, Asselain B. et al . A new 123I-MIBG whole body scan scoring method - application to the prediction of the response of metastases to induction chemotherapy in stage IV neuroblastoma.  Eur J Cancer. 1995;  31 256-261
• 4 Alam M S, Kasagi K, Misaki T. et al . Diagnostic value of technetium-99m methoxyisobutyl isonitrile (99mTc-MIBI) scintigraphy in detecting thyroid cancer metastases: a critical evaluation.  Thyroid. 1998;  8 1091-1100
• 5 Aoki J, Watanabe H, Shinozaki T. et al . FDG PET of primary benign and malignant bone tumors: standardized uptake value in 52 lesions.  Radiology. 2001;  219 774-777
• 6 Atasever T, Gundogdu C, Vural G. et al . Evaluation of pentavalent Tc-99m DMSA scintigraphy in small cell and nonsmall cell lung cancers.  Nuklearmedizin. 1997;  36 223-227
• 7 Backhaus M, Burmester G R, Sandrock D. et al . Prospective two year follow up study comparing novel and conventional imaging procedures in patients with arthritic finger joints.  Ann Rheum Dis. 2002;  61 895-904
• 8 Backhaus M, Kamradt T, Sandrock D. et al . Arthritis of the Finger Joints - A Comprehensive Approach Comparing Conventional Radiography, Scintigraphy, Ultrasound, and Contrast- Enhances Magnetic Resonance Imaging.  Artrit Rheumat. 1999;  42 1232-1245
• 9 Backhaus M, Sandrock D, Schmidt W A. Imaging in der Rheumatologie.  Dtsch med Wschr. (im Druck)
• 10 Bathmann J, Moser E. Vergleich von Skelettszintigraphie und Knochenmarkszintigraphie beim Nachweis ossärer Metastasen.  Radiologe. 1995;  35 8-14
• 11 Benz-Bohm G, Gross-Fengels W, Widemann B, Linden A. Knochenmarkmetastasierung bei Neuroblastom: MRT im Vergleich zur Knochenmarkzytologie und MIBG-Szintigraphie.  Röfo Fortschr Geb Röntgenstr Neuen Bildgeb Verfahr. 1990;  152 523-527
• 12 Blower P J, Kettle A G, O'Doherty M J. et al . 99mTc(V)DMSA quantitatively predicts 188Re(V)DMSA distribution in patients with prostate cancer metastatic to bone.  Eur J Nucl Med. 2000;  27 1405-1409
• 13 Bombardieri E, Martinetti A, Miceli R. et al . Can bone metabolism markers be adopted as an alternative to scintigraphic imaging in monitoring bone metastases from breast cancer.  Eur J Nucl Med. 1997;  24 1349-1355
• 14 Boutin R D, Spitz D J, Newman J S, Lenchik L, Steinbach L S. Complications in Paget disease at MR imaging.  Radiology. 1998;  209 641-651
• 15 Brandt-Mainz K, Müller S P, Görges R, Saller B, Bockisch A. The value of fluorine-18 fluorodeoxyglucose PET in patients with medullary thyroid cancer.  Eur J Nucl Med. 2000;  27 490-496
• 16 Caluser C I, Abdel-Dayem H M, Macapinlac H A. et al . The value of thallium and three-phase bone scans in the evaluation of bone and soft tissue sarcomas.  Eur J Nucl Med. 1994;  21 1198-1205
• 17 Caner B, Kitapci M, Aras T. et al . Increased accumulation of hexakis (2-methoxyisobutylisonitrile)technetium (I) in osteosarcoma and its metastatic lymph nodes.  J Nucl Med. 1991;  32 1977-1978
• 18 Cook G J, Fogelman I. The role of positron emission tomography in the management of bone metastases.  Cancer. 2000;  15 (Suppl) 2927-2933
• 19 Cook G J, Fogelman I. The role of positron emission tomography in skeletal disease.  Semin Nucl Med. 2001;  31 50-61
• 20 Cook G J, Fogelman I. Detection of bone metastases in cancer patients by 18F-fluoride and 18F-fluorodeoxyglucose positron emission tomography.  Q J Nucl Med. 2001;  45 47-52
• 21 Cook G J, Houston S, Rubens R, Maisey M N, Fogelman I. Detection of bone metastases in breast cancer by 18FDG PET: differing metabolic activity in osteoblastic and osteolytic lesions.  J Clin Oncol. 1998;  16 3375-3379
• 22 Cook G J, Maisey M N, Fogelman I. Fluorine-18-FDG PET in Pagett's disease of bone.  J Nucl Med. 1997;  38 1495-1497
• 23 Daldrup-Link H E, Franzius C, Link T M. et al . Whole-body MR imaging for detection of bone metastases in children and young adults: comparison with skeletal scintigraphy and FDG PET.  Am J Roentgenol. 2001;  177 229-236
• 24 Dietlein M, Krug B, Groth W. et al . Positron emission tomography using 18F-fluorodeoxyglucose in advanced stages of malignant melanoma: a comparison of ultrasonographic and radiological methods of diagnosis.  Nucl Med Commun. 1999;  20 255-261
• 25 Dietlein M, Scheidhauer K, Lauterbach K W, Schicha H. Qualitätskriterien für Kosten-Nutzen-Analysen in der onkologischen Nuklearmedizin und Stand ihrer Realisierung.  Z Ärztl Fortbild Qualitätssich. 1999;  93 49-55
• 26 Elgamal A A, Troychak M J, Murphy G P. ProstaScint scan may enhance identification of prostate cancer recurrences after prostatectomy, radiation, or hormone therapy: analysis of 136 scans of 100 patients.  Prostate. 1998;  37 261-269
• 27 Ercan M T, Senekowitsch-Schmidtke R, Bernatz S. Biodistribution of 99mTc- glutathione in mice with osteosarcoma: effect of gamma irradiation on tumour uptake.  Res Exp Med (Berl). 2000;  199 359-367
• 28 Erlemann R, Sciuk J, Bosse A. et al . Response of osteosarcoma and Ewing sarcoma to preoperative chemotherapy: assessment with dynamic and static MR imaging and skeletal scintigraphy.  Radiology. 1990;  175 791-796
• 29 Franzius C, Sciuk J, Brinkschmidt C, Jürgens H, Schober O. Evaluation of chemotherapy response in primary bone tumors with F-18 FDG positron emission tomography compared with histologically assessed tumor necrosis.  Clin Nucl Med. 2000;  25 874-881
• 30 Franzius C, Sciuk J, Daldrup-Link H E, Jürgens H, Schober O. FDG- PET for detection of osseous metastases from malignant primary bone tumours: comparison with bone scintigraphy.  Eur J Nucl Med. 2000;  27 1305-1311
• 31 Frilling A, Malago M, Martin H, Broelsch C E. Use of somatostatin receptor scintigraphy to image extrahepatic metastases of neuroendocrine tumors.  Surgery. 1998;  124 1000-1004
• 32 Gendreau V, Montravers F, Philippe C, Talbot J N. Reevaluation of the usefulness of systematic bone scanning in initial staging and follow-up of small cell lung carcinoma, taking into account the serum levels of neuron-specific enolase.  Int J Biol Markers. 1997;  12 148-153
• 33 Giannakenas C, Kalofonos H P, Apostolopoulos D. et al . Scintigraphic imaging of sarcomatous tumors with [(111)In-DTPA-phe-1]-octreotide.  Oncology. 2000;  58 18-24
• 34 Haines D M, Bruland O S, Matte G. et al . Immunoscintigraphic detection of primary and metastatic spontaneous canine osteosarcoma with F(ab′)2 fragments of osteosarcoma-associated monoclonal antibody TP-1.  Anticancer Res. 1992;  12 2151-2157
• 35 Han L J, Au-Yong T K, Tong W C. et al . Comparison of bone single-photon emission tomography and planar imaging in the detection of vertebral metastases in patients with back pain.  Eur J Nucl Med. 1998;  25 635-638
• 36 Haubner R, Wester H J, Reuning U. et al . Radiolabeled alpha(v)beta3 integrin antagonists: a new class of tracers for tumor targeting.  J Nucl Med. 1999;  40 1061-1071
• 37 Haubold-Reuter B G, Duewell S, Schilcher B R, Marincek B, von Schulthess G K. The value of bone scintigraphy, bone marrow scintigraphy and fast spin-echo magnetic resonance imaging in staging of patients with malignant solid tumours: a prospective study.  Eur J Nucl Med. 1993;  20 1063-1069
• 38 Haukaas S, Roervik J, Halvorsen O J, Foelling M. When is bone scintigraphy necessary in the assessment of newly diagnosed, untreated prostate cancer?.  Br J Urol. 1997;  79 770-776
• 39 Hendler A, Hershkop M. When to use bone scintigraphy. It can reveal things other studies cannot.  Postgrad Med. 1998;  104 54-66
• 40 Herrlin K, Willen H, Wiebe T. Flare phenomenon in osteosarcoma after complete remission.  J Nucl Med. 1995;  36 1429-1431
• 41 Hoh C K, Hawkins R A, Dahlbom, M. et al . Whole body skeletal imaging with 18F fluoride ion and PET.  J Comput Assist Tomogr. 1993;  17 34-41
• 42 Imbriaco M, Yeh S D, Yeung H. et al . Thallium-201 scintigraphy for the evaluation of tumor response to preoperative chemotherapy in patients with osteosarcoma.  Cancer. 1997;  80 1507-1512
• 43 Jager P L, Hoekstra H J, Albertus-Leeuw J. et al . Routine bone scintigraphy in primary staging of soft tissue sarcoma; Is it worthwhile?.  Cancer. 2000;  89 1726-1731
• 44 Kao C H, Hsieh J F, Tsai S C, Ho Y J, Yen R F. Comparison and discrepancy of 18F-2-deoxyglucose positron emission tomography and Tc-99m MDP bone scan to detect bone metastases.  Anticancer Res. 2000;  20 2189-2192
• 45 Kaste S C, Billips C, Tan M. et al . Thallium bone imaging as an indicator of response and outcome in nonmetastatic primary extremity osteosarcoma.  Pediatr Radiol. 2001;  31 251-256
• 46 Kobayashi Y, Ozaki T, Takeda Y, Kawai A, Inoue H. Evaluation of the effect of preoperative chemotherapy in bone sarcomas. 99mTc-HMDP scintigraphy in 34 cases.  Acta Orthop Scand. 1998;  69 611-616
• 47 Kobayashi H, Sakahara H, Hosono M. et al . Improved clearance of radiolabeled biotinylated monoclonal antibody following the infusion of avidin as a „chase” without decreased accumulation in the target tumor.  J Nucl Med. 1994;  35 1677-1684
• 48 Koda M, Okamura T, Kobashi T. et al . A case of an adult neuroblastoma with bone-marrow metastases: 131I-MIBG scintigraphy in comparison with MRI.  Kaku Igaku. 1997;  34 821-826
• 49 Korholz D, Verheyen J, Engelbrecht V. et al . Nachsorge bei Patienten mit Osteosarkom und Ewing-Tumoren. Eine retrospektive Nutzenanalyse.  Klin Pädiatr. 2000;  212 220-223
• 50 Korholz D, Wirtz I, Vosberg H. et al . The role of bone scintigraphy in the follow-up of osteogenic sarcoma.  Eur J Cancer. 1996;  32 A 461-464
• 51 Kotzerke J, Prang J, Neumaier B. et al . Experience with carbon-11 choline positron emission tomography in prostate carcinoma.  Eur J Nucl Med. 2000;  27 1415-1419
• 52 Kunisada T, Ozaki T, Kawai A. et al . Imaging assessment of the responses of osteosarcoma patients to preoperative chemotherapy: angiography compared with thallium-201 scintigraphy.  Cancer. 1999;  86 949-956
• 53 Lam A S, Kettle A G, O'Doherty M J. et al . Pentavalent 99Tcm-DMSA imaging in patients with bone metastases.  Nucl Med Commun. 1997;  18 907-914
• 54 Lau A K, Roach P J. Bone metastases in pheochromocytoma. Optimal timing of I-123 MIBG scintigraphy.  Clin Nucl Med. 1996;  21 316-318
• 55 Lin J, Leung W T, Ho S K. et al . Quantitative evaluation of thallium-201 uptake in predicting chemotherapeutic response of osteosarcoma.  Eur J Nucl Med. 1995;  22 553-555
• 56 Menendez L R, Fideler B M, Mirra J. Thallium-201 scanning for the evaluation of osteosarcoma and soft-tissue sarcoma. A study of the evaluation and predictability of the histological response to chemotherapy.  J Bone Joint Surg Am. 1993;  75 526-531
• 57 Mentes M, Leitha T, Windhager R, Breitenseher M. Nachweis eines im planaren Knochenszintigramm negativen Osteoidosteoms mittels MRT und SPECT.  Röfo Fortschr Geb Röntgenstr Neuen Bildgeb Verfahr. 1997;  167 537-539
• 58 Moser E. Die Bedeutung der Skelettszintigraphie in der Nachsorge von Malignompatienten.  Radiologe. 1990;  30 465-471
• 59 Munz D L. Knochenmarkszintigraphie. Prinzipien, klinische Ergebnisse und Indikationen.  Radiologe. 1992;  32 485-494
• 60 Nishiyama Y, Yamamoto Y, Ono Y. et al . Comparison of Tc-99m-tetrofosmin with Tl-201 and I-131 in the detection of differentiated thyroid cancer metastases.  Nucl Med Commun. 2000;  21 917-923
• 61 Ohta M, Tokuda Y, Suzuki Y. et al . Whole body PET for the evaluation of bony metastases in patients with breast cancer: comparison with 99Tcm-MDP bone scintigraphy.  Nucl Med Commun. 2001;  22 875-879
• 62 Ohtomo K, Terui S, Yokoyama R. et al . Thallium-201 scintigraphy to assess effect of chemotherapy in osteosarcoma.  J Nucl Med. 1996;  37 1444-1448
• 63 Ongolo-Zogo P, Thiesse P, Sau J. et al . Assessment of osteosarcoma response to neoadjuvant chemotherapy: comparative usefulness of dynamic gadolinium-enhanced spin-echo magnetic resonance imaging and technetium-99m skeletal angioscintigraphy.  Eur Radiol. 1999;  9 907-914
• 64 Oommen R, Geethanjali F S, Gopalakrishnan G. et al . Correlation of serum prostate specific antigen levels and bone scintigraphy in carcinoma prostate.  Br J Radiol. 1994;  67 469-471
• 65 Otsuka N, Sone T, Morita K, Fukunaga M. I-123 iodoamphetamine scintigraphic detection of bone metastases from malignant melanoma.  Clin Nucl Med. 1996;  21 847-850
• 66 Ozcan Z, Burak Z, Erinc R. et al . Correlation of 99mTc-sestamibi uptake with blood-pool and osseous phase 99mTc-MDP uptake in malignant bone and soft-tissue tumours.  Nucl Med Commun. 2001;  22 679-683
• 67 Page R L, Garg P K, Garg S. et al . PET imaging of osteosarcoma in dogs using a fluorine-18-labeled monoclonal antibody Fab fragment.  J Nucl Med. 1994;  35 1506-1513
• 68 Perkins A C, Hardy J G. Intra-operative nuclear medicine in surgical practice.  Nucl Med Commun. 1996;  17 1006-1015
• 69 Piepenburg R, Bockisch A, Hach A. et al . Bedeutung der Ganzkörper-Skelettszintigraphie im Rahmen des Staging von Malignomen im HNO-Bereich.  Laryngorhinootologie. 1992;  71 605-610
• 70 Reske S, Kartsens J, Sohn M, Glöckner W, Büll U. Bone marrow immunoscintigraphy compared with conventional bone scintigraphy for the detection of bone metastases.  Acta Oncol. 1993;  32 753-761
• 71 Roach P J, Connolly L P, Zurakowski D, Treves S T. Osteoid osteoma: comparative utility of high-resolution planar and pinhole magnification scintigraphy.  Pediatr Radiol. 1996;  26 222-225
• 72 Robinson L A, Preksto D, Muro-Cacho C, Hubbell D S. Intraoperative gamma probe-directed biopsy of asymptomatic suspected bone metastases.  Ann Thorac Surg. 1998;  65 1426-1432
• 73 Rosen G, Loren G J, Brien E W. et al . Serial thallium-201 scintigraphy in osteosarcoma. Correlation with tumor necrosis after preoperative chemotherapy.  Clin Orthop. 1993;  293 302-306
• 74 Rosselli-Del-Turco M, Palli D, Cariddi A. et al . Intensive diagnostic follow-up after treatment of primary breast cancer. A randomized trial. National Research Council Project on Breast Cancer follow-up.  JAMA. 1994;  271 1593-1597
• 75 Ryan P J, Fogelman I. Bone SPECT in osteoid osteoma of the vertebral lamina.  Clin Nucl Med. 1994;  19 144-145
• 76 Sahin M, Basoglu T, Bernay I. et al . Evaluation of metastatic bone disease with pentavalent 99Tc(m)- dimercaptosuccinic acid: a comparison with whole-body scanning and 4/24 hour quantitation of vertebral lesions.  Nucl Med Commun. 2000;  21 251-258
• 77 Sandrock D, Backhaus M, Burmester G, Munz D L. Bildgebende Verfahren in der Rheumatologie: Szintigraphie bei rheumatoider Arthritis.  Dtsch Z Rheumatologie. (im Druck)
• 78 Sato O, Kawai A, Ozaki T. et al . Value of thallium-201 scintigraphy in bone and soft tissue tumors.  J Orthop Sci. 1998;  3 297-303
• 79 Sautter-Bihl M L, Bihl H, Heinze H G. Stellenwert der 99mTc-MDP-Skelettszintigraphie beim Neuroblastom. Ist eine Neubewertung nötig?.  Nuklearmedizin. 1991;  30 7-12
• 80 Savelli G, Maffioli L, Maccauro M, De-Deckere E, Bombardieri E. Bone scintigraphy and the added value of SPECT (single photon emission tomography) in detecting skeletal lesions.  Q J Nucl Med. 2001;  45 27-37
• 81 Schirrmeister H, Guhlmann A, Kotzerke J. et al . Early detection and accurate description of extent of metastatic bone disease in breast cancer with fluoride ion and positron emission tomography.  J Clin Oncol. 1999;  17 2381-2389
• 82 Schirrmeister H, Kotzerke J, Rentschler M. et al . Die Positronenemissionstomographie des Skelettsystems mit 18FNa: Häufigkeit, Befundmuster und Verteilung benigner Veränderungen.  Röfo Fortschr Geb Röntgenstr Neuen Bildgeb Verfahr. 1998;  169 310-314
• 83 Schmidt M, Scheidhauer K, Luyken C. et al . Somatostatin receptor imaging in intracranial tumours.  Eur J Nucl Med. 1998;  25 675-686
• 84 Schünemann H, Langecker P J, Ellgas W, Leonhardt A, Merkl H. Value of bone scanning in the follow-up of breast cancer patients. A study of 1 000 cases.  J Cancer Res Clin Oncol. 1990;  116 486-491
• 85 Schulte M, Brecht-Krauss D, Werner M. et al . Evaluation of neoadjuvant therapy response of osteogenic sarcoma using FDG PET.  J Nucl Med. 1999;  40 1637-1643
• 86 Schultze J, Kimmig B. Wertigkeit der Knochenszintigraphie fur die Bestrahlungsplanung im Skelettsystem.  Nuklearmedizin. 1996;  35 59-62
• 87 Sedonja I, Budihna N V. The benefit of SPECT when added to planar scintigraphy in patients with bone metastases in the spine.  Clin Nucl Med. 1999;  24 407-413
• 88 Seeger L L, Gold R H, Chandnani V P. Diagnostic imaging of osteosarcoma.  Clin Orthop. 1991;  270 254-263
• 89 Shirato M, Yasukochi H, Higashi S, Takahashi T. 67Ga scintigram and MRI in malignant bone tumors and malignant soft tissue tumors.  Kaku Igaku. 1992;  29 635-638
• 90 Sissons G R, Clements R, Peeling W B, Penney M D. Can serum prostate- specific antigen replace bone scintigraphy in the follow-up of metastatic prostatic cancer?.  Br J Radiol. 1992;  65 861-864
• 91 Smolarz K, Jungehülsing M, Krug B. et al . Kernspintomographie des Knochenmarks bei Karzinompatienten mit einer solitären Mehranreicherung im Skelettszintigramm.  Nuklearmedizin. 1990;  29 269-273
• 92 Soderlund V, Larsson S A, Bauer H C. et al . Use of 99mTc-MIBI scintigraphy in the evaluation of the response of osteosarcoma to chemotherapy.  Eur J Nucl Med. 1997;  24 511-515
• 93 Spitz J, Becker C, Tittel K, Weigand H. Die klinische Relevanz der Ganzkörperskelettszintigraphie bei mehrfachverletzten und polytraumatisierten Patienten.  Unfallchirurgie. 1992;  18 133-147
• 94 Spitz J, Lauer I, Tittel K. Untersuchungen zur Altersabhängigkeit der traumatisch induzierten ossären Umbaureaktion im Skelettszintigramm.  Nuklearmedizin. 1991;  30 155-160
• 95 Spitz J, Lauer I, Tittel K, Wiegand H. Scintimetric evaluation of remodeling after bone fractures in man.  J Nucl Med. 1993;  34 1403-1409
• 96 Staudenherz A, Steiner B, Puig S, Kainberger F, Leitha T. Is there a diagnostic role for bone scanning of patients with a high pretest probability for metastatic renal cell carcinoma?.  Cancer. 1999;  85 153-155
• 97 Steinborn M M, Heuck A F, Tiling R. et al . Whole-body bone marrow MRI in patients with metastatic disease to the skeletal system.  J Comput Assist Tomogr. 1999;  23 123-129
• 98 Sueyoshi K, Narabayashi I, Aratani T. et al . Utility of Tc-99m GSA whole-body scintigraphy in detecting bone metastases from hepatocellular carcinoma.  Clin Nucl Med. 2001;  26 221-224
• 99 Suto Y, Iwamiya T, Tanigawa N, Shabana M, Ohta Y. Clinical experience of 123I-IMP scintigraphy in detecting vertebral bone metastases of hepatocellular carcinoma. A comparison with bone scintigraphy with 99mTc-MDP.  Acta Radiol. 1994;  35 159-163
• 100 Suto Y, Tanigawa N, Iwamiya T, Shabana M, Ohta Y. The potential use of I-123 IMP scintigraphy for pelvic bone metastases in hepatocellular carcinoma. A comparison with Ga-67 scintigraphy.  Clin Nucl Med. 1994;  19 302-306
• 101 Tamada T, Nagai K, Iizuka M. et al . Comparison of whole-body MR imaging and bone scintigraphy in the detection of bone metastases from breast cancer.  Nippon Igaku Hoshasen Gakkai Zasshi. 2000;  60 249-254
• 102 Tausig A, Manthey N, Berger F. et al . Vorzüge und Limitationen der Ganzkörper-Knochenmark-MRT mit Turbo-STIR-Sequenzen im Vergleich zur planaren Skelettszintigraphie.  Nuklearmedizin. 2000;  39 174-179
• 103 Theissen P, Smolarz K, Scharl A. et al . Kernspintomographie zum Metastasen-Screening? Ein prospektiver Vergleich mit der Skelettszintigraphie.  Nuklearmedizin. 1994;  33 132-137
• 104 Traill Z C, Talbot D, Golding S, Gleeson F V. Magnetic resonance imaging versus radionuclide scintigraphy in screening for bone metastases.  Clin Radiol. 1999;  54 448-451
• 105 Traub T, Petkov V, Ofluoglu S. et al . 111In-DOTA- lanreotide scintigraphy in patients with tumors of the lung.  J Nucl Med. 2001;  42 1309-1315
• 106 Van Laere K, Casier K, Uyttendaele D. et al . Technetium-99m-MDP scintigraphy and long-term follow-up of treated primary malignant bone tumors.  J Nucl Med. 1998;  39 1563-1569
• 107 Venz S, Hosten N, Friedrichs R. et al . Osteoplastische Knochenmetastasen beim Prostatakarzinom: Magnetresonanztomographie und Knochenmarkszintigraphie.  Röfo Fortschr Geb Röntgenstr Neuen Bildgeb Verfahr. 1994;  161 64-69
• 108 Vijayakumar V, Vijayakumar S, Quadri S F, Blend M J. Can prostate-specific antigen levels predict bone scan evidence of metastases in newly diagnosed prostate cancer?.  Am J Clin Oncol. 1994;  17 432-436
• 109 Wester H J, Herz M, Senekowitsch-Schmidtke R. et al . Preclinical evaluation of 4-[18F]fluoroprolines: diastereomeric effect on metabolism and uptake in mice.  Nucl Med Biol. 1999;  26 259-265
• 110 Willkomm P, Bender H, Bangard M. et al . FDG PET and immunoscintigraphy with 99mTc-labeled antibody fragments for detection of the recurrence of colorectal carcinoma.  J Nucl Med. 2000;  41 1657-1663
• 111 Wioland M, Sergent-Alaoui A. Didactic review of 175 radionuclide-guided excisions of osteoid osteomas.  Eur J Nucl Med. 1996;  23 1003-1011
• 112 Yeh K A, Fortunato L, Ridge J A. et al . Routine bone scanning in patients with T1 and T2 breast cancer: a waste of money.  Ann Surg Oncol. 1995;  2 319-324
• 113 Zöller G, Sandrock D, Munz D L, Ringert R H. Bone marrow immunoscintigraphy versus conventional bone scintigraphy in the diagnosis of skeletal metastases in urogenital malignancies.  Eur Urol. 1994;  26 141-144