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Pneumologie 2003; 57(2): 91-97
DOI: 10.1055/s-2003-37153
Übersicht
© Georg Thieme Verlag Stuttgart · New York

Die Bedeutung von Zytokinen und Wachstumsfaktoren bei fibrosierenden Lungenerkrankungen

The Role of Cytokines and Growth Factors in Fibroproliferative Lung DiseaseM.  Kolb1 , M.  Schmidt1
  • 1Medizinische Klinik der Julius-Maximilian-Universität Würzburg, Schwerpunkt Pneumologie (Direktor: Prof. Dr. G. Ertl)
DanksagungDie wissenschaftliche Arbeit des Erstautors wird gefördert durch die Stiftung Deutsche Krebshilfe, Deutsche Forschungsgemeinschaft, Canadian Institute of Health Research und die Parker B. Francis Foundation.
Further Information

Publication History

Eingereicht: 31. Juli 2002

Nach Überarbeitung angenommen: 4. November 2002

Publication Date:
11 February 2003 (online)

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Zusammenfassung

Ein neues pathogenetisches Konzept zur Fibrogenese hat die Hypothese aufgestellt, dass es sich bei der Fibrose um „pathologische Wundheilung” oder gestörtes „Remodeling” handelt und Entzündungsvorgänge sekundär sind. Zytokine sind bei diesem Prozess maßgeblich involviert und ein attraktives Ziel für pharmakologische Interventionen. TGFβ hat als profibrotischer Wachstumsfaktor eine Schlüsselstellung und kann auf verschiedenen Wegen inaktiviert oder in seiner Wirkung abgeschwächt werden. Diese Übersichtsarbeit erläutert die Grundlagen der pathobiologischen Abläufe und stellt ihre potenzielle klinische Bedeutung dar.

Abstract

A new hypothesis of the pathogenesis of fibroproliferative lung disease suggests that fibrosis is caused by abnormal and excessive wound healing and pathologic tissue remodelling. Inflammation is possibly an epiphenomenon. Cytokines are critical players in the pathologic process and attractive targets for pharmacological intervention. TGFβ is a key profibrotic growth factor, a variety of approaches are known to modify and inhibit its activity. This article reviews the basic pathological concepts of pulmonary fibrogenesis and outlines its potential clinical benefit.

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Dr. med. M. Kolb

Medizinische Universitätsklinik · Schwerpunkt Pneumologie

Josef-Schneider-Str. 11

97080 Würzburg

Email: kolb_m@klinik.uni-wuerzburg.de

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