Exp Clin Endocrinol Diabetes 2003; 111(1): 2-7
DOI: 10.1055/s-2003-37492

J. A. Barth Verlag in Georg Thieme Verlag Stuttgart · New York

Leptin Resistance - Or Why Leptin Fails to Work in Obesity

K. El-Haschimi 1 , H. Lehnert 1
  • 1Department of Endocrinology and Metabolism, Otto-Von-Guericke University, Magdeburg, Germany
Further Information

Publication History

Received: May 16, 2002 First decision: July 22, 2002

Accepted: August 20, 2002

Publication Date:
26 February 2003 (online)


In experimental models of obesity high serum concentrations of leptin without subsequent inhibition of food intake indicate a resistance to the physiological effects of leptin. Similar to the animal model leptin concentrations in most of the obese patients are higher compared to normal-weight persons. The postulated leptin resistance is one major target in the search for a better understanding of obesity and the development of pharmacological tools to treat this spreading disease.


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Hendrik Lehnert

Department of Endocrinology and Metabolism · Otto-Von-Guericke University

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