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Thorac Cardiovasc Surg 2003; 51(3): 138-141
DOI: 10.1055/s-2003-40314
Original Cardiovascular
© Georg Thieme Verlag Stuttgart · New York

Intracellular Adhesion Molecule-1 in Patients Developing Pulmonary Insufficiency after Cardiopulmonary Bypass

G.  Görlach1 , J.  Sroka1 , M.  Heidt1 , I.  Knez1 , A.  Sablotzki2 , M.  Schönburg1 , H.  Akintürk1 , P.  Roth1 , G.  Wozniak1 , P.  R.  Vogt1
  • 1Department of Cardiovascular Surgery, University Hospital, Giessen, Germany
  • 2Department of Anaesthesiology and Intensive Care Medicine, University Hospital, Giessen, Germany
Further Information

Publication History

Received: August 18, 2002

Publication Date:
30 June 2003 (online)

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Abstract

Objectives: Cardiopulmonary bypass activates adhesion molecules, which are associated with systemic inflammation and organ dysfunction. The intracellular adhesion molecule-1 (ICAM-1) has been evaluated in patients presenting pulmonary dysfunction after cardiac surgery. Materials and Methods: Postoperative serum levels of the ICAM-1 were measured in 40 patients who underwent isolated coronary artery bypass grafting, in 28 with uneventful postoperative recovery (70 %) (Group 1), and in 12 (30 %) with postoperative respiratory insufficiency (Group 2), defined by the need for prolonged (> 24 hours) mechanical ventilation using a fractional oxygen concentration of > 40 %. Results: Patients in group 1 were ventilated for 12.21 ± 4.86 hours and those in group 2 for 92.91 ± 48.14 hours (p < 0.001). ICAM-1 decreased from 145.98 ± 73.40 ng/ml to 81.15 ± 114.82 ng/ml in group 1, while in group 2 ICAM-1 showed a significant higher level and increased to 435.01 ± 130.02 ng/ml (p < 0.001). The leukocyte count increased in both groups as well as the C-reactive protein (CRP) during the postoperative course. The CRP behaves similar in both groups (p = 0.636) in contrast to the leukocyte count which was significantly higher in group 2 (p < 0.01). While none of the patients in group 1 died the mortality in group 2 was 50 % (p < 0.001). Conclusion: Respiratory insufficiency after cardiopulmonary bypass is associated with a distinct increase in the ICAM-1. The reason for the increase of the ICAM-1 in this small subset of patients has not been clarified.

Key words

Pulmonary insufficiency - ICAM-1 - cardiopulmonary bypass

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MD Gerold Görlach

Department of Cardiovascular Surgery, University Hospital

Rudolf-Buchheim-Strasse 7

35385 Giessen

Germany

Phone: +49/641/99 44 333

Fax: +49/641/99 44 309

Email: Gerold.Goerlach@chiru.med.uni-giessen.de

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