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Horm Metab Res 2003; 35(9): 532-536
DOI: 10.1055/s-2003-42654
Original Clinical
© Georg Thieme Verlag Stuttgart · New York

Effect of Doxazosin on Insulin Resistance in Hypertensive Patients with Obesity

H.  Ueshiba1 , Y.  Miyachi1
  • 1First Department of Internal Medicine, Toho University School of Medicine, Ohmori-Nishi, Ohta-ku, Tokyo, Japan
Further Information

Publication History

Received 20 November 2002

Accepted after Revision 11 March 2003

Publication Date:
30 September 2003 (online)

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Abstract

We determined the effect of α-adrenergic blocking agent doxazosin on insulin resistance in 19 hypertensive patients (blood pressure [BP] >160/90 mmHg) with obesity (mean body mass index [BMI]: 26.7 ± 1.9 kg/m2). Patients received doxazosin 4 mg/day for 12 months. Systolic and diastolic BP decreased from 169 ± 10.8 mmHg to 147 ± 11.9 mmHg (p < 0.0001) and from 102 ± 8.1 mmHg to 87 ± 5.0 mmHg (p < 0.0001), respectively. Insulin resistance and fasting immunoreactive insulin (IRI) were lower at study end vs. baseline (HOMA-R = 1.29 ± 0.38 vs. 3.58 ± 2.23 [p = 0.022]; IRI = 6.00 ± 1.88 µU/ml vs 13.74 ± 8.51 µU/ml [p = 0.046]). Total cholesterol was significantly reduced following treatment. Circulating TNF-α and leptin levels decreased significantly within 3 months of treatment; leptin was independently associated with insulin resistance when adjusted for BMI. We conclude that doxazosin improves insulin resistance and improves dyslipidemia in obese hypertensive patients, and has a beneficial effect on adipose endocrine activity.

Key words

Hypertension - Obesity - Doxazosin - Insulin - Leptin - Adrenergic Alpha-Antagonists - Tumor Necrosis Factor

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H. Ueshiba

First Department of Internal Medicine · Toho University School of Medicine ·

6-11-1 Ohmori-Nishi · Ohta-ku · Tokyo, 143 - 0015 · Japan

Phone: +81(3)3762-4151

Fax: +81(3)37638298 ·

Email: ueshiba@med.toho-u.ac.jp

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