Zusammenfassung
Die Posttraumatische Belastungsstörung (PTBS) hat aufgrund ihres häufigen Vorkommens
neben der medizinischen auch eine große soziale und wirtschaftliche Bedeutung. Nicht
nur die medizinische Behandlungsnotwendigkeit, sondern auch volkswirtschaftliche Gesichtspunkte
verlangen nach einer effizienten Therapie der Betroffenen. Schätzungen von direkten
und indirekten Folgekosten der PTBS in den USA, bewegen sich, nicht zuletzt als Folge
der Ereignisse vom 11. Sept. 2001, im mehrstelligen Milliarden-Dollar-Bereich. Die
Behandlung der PTBS gestaltet sich aufgrund von häufigen komorbid auftretenden Erkrankungen
schwierig. Die Begleiterkrankungen sind mannigfaltig und decken den gesamten Bereich
psychischer Erkrankungen ab. Die nosologische Eigenständigkeit der PTBS wird durch
vielfältige organische Befunde aus der Elektrophysiologie und der funktionellen Bildgebung
belegt. Ein sich mittlerweile aus vielen Richtungen abzeichnendes organisches Korrelat
und eine Vielzahl von Verhaltensauffälligkeiten stellen weitere Ansatzpunkte für eine
adäquate Therapie dar, die auf das Individuum abgestimmt und in einem integrativen
Ansatz sowohl aus pharmakologischen als auch aus psychotherapeutischen Komponenten
bestehen sollte.
Abstract
Besides a huge impact on psychiatric burden of disease, post-traumatic stress disorder
(PTSD) is of immense socioeconomic importance. Not only medical, but also economical
aspects demand an effective treatment of PTSD: direct and indirect costs of PTSD in
the United States of America are estimated several billion dollars. Due to frequent
co-morbidities, PTSD therapy proves to be complex and difficult. Co-morbid diseases
are numerous and cover almost the whole field of psychiatry. The delineation of PTSD
as a distinct nosological entity is however meanwhile substantiated by various findings
generated by the means of multimodal neuroimaging, e. g. electrophysiological or functional
imaging techniques. Converging lines of evidence, arguing for an organic correlate
of PTSD, and widespread behavioural disturbances provide a further rationale for an
adequate treatment of PTSD. This should be individually tailored for every patient
and include both pharmacological as well as cognitive-behavioural methods to provide
a modern, integrative approach to meet the requirements of this complex disease.
Schlüsselwörter
Posttraumatische Belastungsstörung - PTBS - PTSD - Therapie - Kosten - Ökonomie -
Komorbide Erkrankungen - Pharmakotherapie - Kognitiv-behaviorale Therapie - Debriefing
- Psychotherapie
Key words
Posttraumatic stress disorder - PTSD - therapy - costs - economy - co-morbid disorders
- pharmacotherapy - cognitive-behavioural therapy - debriefing - psychotherapy
Literatur
- 1 Statistisches Bundesamt in Wiesbaden .Die Gesundheitsberichterstattung des Bundes
im Auftrag des Bundesministeriums für Bildung und Forschung. www.gbe-bund.de
- 2
Frommberger U, Stieglitz R D, Nyberg E, Schlickewei W, Kuner E, Berger M.
Prediction of posttraumatic stress disorder by immediate reactions to Trauma: a prospective
study in road traffic accident victims.
Eur Arch Psychiatry Clin Neurosci.
1998;
248
316-321
- 3 Schnyder U. Die psychosozialen Folgen schwerer Unfälle. Darmstadt: Steinkopf 2000
- 4 Miller N E, Magruder K M. Cost-Effectiveness of psychotherapy. New York: Oxford
University Press 1999: Chapter 24, Jaycox LH, Foa EB, S. 259-259
- 5 Suchtjahrbuch. Deutschland 2000
- 6 Kulka R A, John A, Fairbank B. Trauma and the Vietnam War generation: Report of
findings from the National Vietnam Veterans, Readjustment Study. New York: Brunner/Mazel
1990
- 7
Koss M P, Koss P G, Woodruff W J.
Deleterious effects of criminal victimization on woman's health and medical utilization.
Arch Intern Med.
1991;
151
342-347
- 8
Walker E A, Unutzer J, Rutter C.
Costs of health care use by woman HMO members with a history of childhood abuse and
neglect.
Arch Gen Psychiatry.
1999;
56
609-613
- 9
New M, Berliner L.
Mental health service utilisation by victims of crime.
J Trauma Stress.
2000;
13
693-707
- 10
Kessler R C, Frank R G.
The impact of psychiatric disorders on work loss days.
Psychol Med.
1997;
27
861-873
- 11
Kessler R C.
Posttraumatic Stress Disorder: The Burden to the Individual and to Society.
J Clin Psychiatry.
2000;
61 (suppl 5)
4-12
- 12 Miller T R, Cohen M A, Wiesrma B. Victim costs and consequences: a new look. Washington
DC: United States Department of Justice, National Institute of Justice. Research Report
1996
- 13
Duncan R D, Saunsers B E, Kilpatrick D G, Rochelle F.
Childhood physical assault as a risk factor for PTSD, depression and substance abuse:
Findings form a national survey.
Am J Orthopsych.
1996;
66
437-448
- 14
Kessler R C, Sonnega A, Bromet E.
Posttraumatic stress disorder in the National Comorbidity Survey.
Arch Gen Psychiatry.
1995;
52
1048-1060
- 15
Breslauf N, Davis G C, Andreski P.
Traumatic events and posttraumatic stress disorder in an urban population of young
adults.
Arch Gen Psychiatry.
1991;
48
216-222
- 16
Deering C G, Glover S G, Ready D.
Unique patterns of comorbidity in post traumatic stress disorder from different sources
of trauma.
Compr Psychiatry.
1996;
37
336-346
- 17
Gibson L E, Holt J C, Fondacaro K M, Tang T S, Powell T A, Turbitt E L.
An examination of antecedent traumas and psychiatric comorbidity among male inmates
with PTSD.
Journal of Traumatic Stress.
1999;
12
473-484
- 18
Kessler R C, Borges G, Walters E E.
Prevalence of and risk factors for lifetime suicide attempts in the national comorbidity
survey.
Arch Gen Psychiatry.
1999;
56
617-626
- 19
Ferrada-Noli M, Asberg M, Ormstad K, Lundin T, Sundbom E.
Suicidal behavior after severe trauma. Part 1: PTSD diagnosis, psychiatric comorbidity
and assessments of suicidal behavior.
Journal of Traumatic Stress.
1998;
11
103-112
- 20
Acinero R, Kilpatrick D G, Resnick H, Saunders B, De Arellano M, Best C.
Assault, PTSD, family substance use and depression as risk factors for cigarette use
in youth: Findings from the national survey of adolescents.
Journal of Traumatic Stress.
2000;
13
381-396
- 21
Brown P J, Stout R L, Gannon-Rowley J.
Substance use disorder-PTSD comorbidity. Patients'perceptions of symptom interplay
and treatment issues.
Journal of Substance Abuse and its Treatment.
1998;
15
445-448
- 22 Yehuda R. Risk factors for PTSD. Washington DC, London, England: American Psychiatric
Press, Inc 1999
- 23
Zlotnick C, Warshaw M, Shea M T, Allsworth J.
Chronicity in PTSD and predictors of course of comorbid PTSD in patients with anxiety
disorders.
J of Traumatic Stress.
1999;
12
89-99
- 24
Maes M, Delmeire L, Mylle J, Altamura C.
Risk and preventive factors of PTSD: Alcohol consumption and intoxication prior to
a traumatic event diminishes the relative risk to develop PTSD in response to that
trauma.
J Affect Disord.
2001;
63
113-121
- 25
Deahl M P, Gillham A B, Thomas J.
Psychological sequelae following the Gulf War. Factors associated with subsequent
morbidity and the effectiveness of psychological debriefing.
Br J Psychiatry.
1994;
165 (2)
60-65
- 26
Deahl M P, Srinivasan M, Jones N.
Evaluating psychological debriefing: are we measuring the right outcomes?.
J Trauma Stress.
2001;
14 (3)
527-529
- 27
Carol S, Fullerton Ph D, Robert J.
Debriefing Following Trauma.
Psychiatric Q.
2000;
71
259-276
- 28
Suzanna R, Jonathan B, Simon W.
Psychological debriefing for preventing PTSD.
Cochrane Database Syst Rev.
2001;
(3)
CD000560
- 29
Horowitz M J.
Stress response syndromes. Character style and dynamic psychotherapy.
Arch Gen Psychiatry.
1974;
31
768-781
- 30
Reist C, Kauffmann C D, Haier R J.
A controlled trial of desipramine in 18 men with PTSD.
Am J Psychiatry.
1989;
146
513-516
- 31
Davidson J RC, Kudler H, Smith R.
Treatment of PTSD with amitriptyline and placebo.
Arch Gen Psychiatry.
1990;
47
259-266
- 32
Kosten T R, Frank J B, Dan E.
Pharmacotherapy for PTSD using phenelzine or imipramine.
J Nerv Ment Dis.
1991;
179
366-370
- 33
Van der Kolk B A, Dreyfull D, Michaels M.
Fluoxetine in PTSD.
J Clin Psychiatry.
1994;
55
517-522
- 34
Marshall R D, Schneider F R, Knight C BG.
An open trial of Paroxetine in patients with combat-related chronic PTSD.
J Clin Psychopharmacol.
1998;
18
10-18
- 35
Brady K T, Sonne S C, Roberts J M.
Sertraline in the treatment of rape victims with PTSD and alcohol dependence.
J Clin Psychiatry.
1995;
56
502-505
- 36
Kline N A, Dow B M, Brown S A.
Sertraline efficacy in depressed combat veterans with PTSD.
Am J Psychiatry.
1994;
151
621
- 37
DeBoer M, Op den Velde W, Falger P J.
Fluvoxamine treatment for chronic PTSD: A pilot study.
Psychother Psychosom.
1992;
57
158-163
- 38
Marmar C R, Schoenfeld F, Weiss D S.
Open trial of fluvoxamine treatment for combat-related PTSD.
J Clin Psychiatry.
1996;
57 (Suppl.)
66-72
- 39
Baker D G, Diamond B I, Gillette G.
A double-blind, randomized, placebo-controlled, multicenter study of brofaromine in
the treatment of PTSD.
Psychopharmacology.
1995;
122
386-389
- 40
Katz R J, Lott M H, Arbus P.
Pharmacotherapy of PTSD with a novel psychotropic.
Anxiety.
1995;
1
169-174
- 41
Neal L A, Sapland W, Fox C.
An open trial of moclobemide in the treatment of PTSD.
Int Clin Psychopharmacol.
1997;
12
231-315
- 42
Lowenstein R J, Hornstein N, Farber B.
Open trial of clonazepam in the treatment of post traumatic stress symptoms in multiple
personality disorder.
Dissociation.
1988;
1
2-12
- 43
Kitchner I, Greenstein R.
Low dose lithium carbonate in the treatment of PTSD.
Mil Med.
1985;
150
378-381
- 44
Van der Kolk B A.
Psychopharmacological issues in PTSD.
Hosp Comm Psychiatry.
1983;
34
683-691
- 45
Forster P L, Schoenfeld F B, Marmar C R.
Lithium for irritability in PTSD.
J Traum Stress.
1995;
8
143-149
- 46
Lipper S, Hammett E B, Davidson J RT.
Preliminary study of carbamazepine in PTSD.
Psychosomatics.
1986;
27
849-854
- 47
Looff D, Grimley P, Kuller F.
Carbamazepine for PTSD.
J Am Acad Child Adolesc Psychiatry.
1995;
34
703-704
- 48
Wolf M E, Alavi A, Mosnaim A D.
PTSD in Vietnam Veterans: Clinical and EEG findings; possible therapeutic effects
of carbamazepine.
Biol Psychiatry.
1988;
23
642-644
- 49
Donovan S J, Susser E S, Nunes E V.
Divalproex treatment of disruptive adolescents: A report on 10 cases.
J Clin Psychiatry.
1997;
58
12-15
- 50
Fesler F A.
Valproate in combat-related PTSD.
J Clin Psychiatry.
1991;
52
361-364
- 51
Szymansky H V, Olympia J.
Divalproex In PTSD.
Am J Psychiatry.
1991;
148
1086-1087
- 52 Kolb L C, Burris B C, Griffith S. Propranolol and clonidine in the treatment of
PTSD of war: Psychological and biological sequelae. Washington/DC, London: American
Psychiatric Press 1984: pp 98-105
- 53
Hamner M B.
Clozapine treatment for a veteran with comorbid psychosis and PTSD.
Am J Psychiatry.
1996;
60
309-318
- 54
Solomon S D, Gerrity E T, Muff A M.
Efficacy of treatments for PTSD. An empirical review.
JAMA.
1992;
286
633-638
- 55
Ebbinghaus R, Bauer M, Riebe S.
Behandlung der PTBS.
Fortschr Neurol Psychiat.
1996;
64
433-443
- 56
Shalev A Y, Bonne O, Eth S P.
Treatment of PTSD: A review.
Psychosom Med.
1996;
58
165-182
- 57 Gerrity E T, Solomon S D. The treatment of PTSD and related stress disorders. Current
research and clinical knowledge. In: Marsella AJ, Friedmann M, Spain B. Ethnocultural
Aspects of PTSD. Washington, DC: American Psychological Association 1996: 87-102
- 58
Foa E B, Meadows E A.
Psychosocial treatments for PTSD. A critical review.
Ann Rev Psychol.
1997;
48
449-480
- 59
Sherman J J.
Effects of psychotherapeutic treatments for PTSD: a meta-analysis of controlled clinical
trials.
J Trauma Stress.
1998;
11
413-435
- 60
van Etten M L, Taylor S.
Comparative efficacy of treatments for PTSD: a meta-analysis.
J Clin Psychol Psychother.
1998;
5
126-144
- 61
Shepherd J, Stein K, Milne R.
EMDR in the treatment of PTSD: a review of an emerging therapy.
Psychol Med.
2000;
30
863-871
Dr. Stephan Kamolz
Klinik und Poliklinik für Psychiatrie und Psychotherapie der Universität Würzburg
Füchsleinstraße 15
97080 Würzburg