A Chemoenzymatic Approach to Optically Active 5-Hydroxy-3-oxo-carboxylates

Chengfu Xu; Yonghui Zhang; Chengye Yuan

doi:10.1055/s-2004-817746

LETTER

A Chemoenzymatic Approach to Optically Active 5-Hydroxy-3-oxo-carboxylates

Chengfu Xu, Yonghui Zhang, Chengye Yuan*
Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai, 200032, P. R. China
Fax: +86(21)64166128; e-Mail: yuancy@mail.sioc.ac.cn;

Abstract

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Abstract

Enzymatic hydrolysis was applied to the preparation of certain chiral 5-hydroxy-3-oxo-carboxylates that are potential precursors for natural product synthesis via the formation of lactone derivatives and tetrahydropyran rings.

Key words

5-hydroxy-3-oxo-carboxylates - 6-substituted-4-hydroxy lactones - tetrahydropyran-4-ones - Candia Rugosa lipase (CRL) - enzymatic hydrolysis

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References

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Conditions of chiral HPLC were recorded in Table [2] .

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