Geburtshilfe und Frauenheilkunde, Table of Contents Geburtshilfe Frauenheilkd 2003; 63(2): R21-R40DOI: 10.1055/s-2004-817984 GebFra-Refresher Georg Thieme Verlag Stuttgart · New YorkTherapie der drohenden Frühgeburt - Teil 2L. Spätling1 , H. Schneider2 1Fulda 2Bern Recommend Article Abstract Buy Article Full Text References Literatur 1 ACOG . Preterm Labor. Technical Bulletin. 1995; 206 1-10 2 Altura B M, Altura B T. Magnesium ions and contraction of vascular smooth muscles: relationship to some vascular diseases. Fed Proc. 1981; 40 2672-679 3 Alvan G, Orme M, Bertilsson L, Akstrand R, Palmer L. Pharmacokinetics of indomethacin. Clin Pharmacol Ther. 1975; 18 369-373 4 Behrens C, Fallenstein F, Koch K, Spätling L. Ein neuer Ansatz zur Optimierung der Dosierung bei pulsatiler Bolustokolyse. Geburtsh Frauenheilk. 1998; 58 251-256 5 Berg G, Andersson R G, Ryden G. In vitro study of phosphodiesterase-inhiting drugs: a complement to beta-sympathometric drug therapy in premature labor?. Amer J Obstet Gynec. 1983; 145 802-806 6 Berg G, Andersson R G, Ryden G. Beta-adrenergic receptors in human myometrium during pregnancy: changes in the number of receptors after betamimetic treatment. Amer J Obstet Gynec. 1985; 151 392-396 7 Besinger R E, Niebyl J R. The safety and efficacy of tocolytic agents for the treatment of preterm labor. Obstet Gynec Surv. 1990; 45 415-440 8 Canadian Preterm Labor Investigators Group . Treatment of preterm labor with the beta-adrenergic agonist ritodrine. New Engl J Med. 1992; 327 308-312 9 Caritis S N, Venkataramanam R, Darby M J, Chiao J P, Krew M. Pharmacokinetics of ritodrine administered intravenously: recommendations for changes in the current regimen. Amer J Obstet Gynec. 1990; 162 429-437 10 Challis J R, Matthews S G, Gibb W, Lye S I. Endocrine and paracrine regulation of birth at term and preterm. Endocrin Rev. 2000; 21 514-550 11 Challis J RG. Mechanisms of parturition and preterm labour. Obstet Gynecol Surv. 2000; 55 650-660 12 Carlan S J, O'Brien W F, O'Leary T D, Mastrogiannis D. Randomized comparative trial of indomethacin and sulindac for the treatment of refractory preterm labor. Obstet and Gynec. 1992; 79 223-228 13 Chau C G, Gabert H A, Miller J M. A prospective comparison of terbutaline and magnesium for tocolysis. Obstet and Gynec. 1992; 80 847-851 14 Classen H G, Ebel H, Späth M, Marquardt P, Schumacher K A. Production of cardiac necroses in rats - kept on a magnesium- and chloride-deficient diet - by epinephrine and their prevention by magnesium compounds. Naunyn-Schmiedeberg's Arch Pharmacol. 1975; R35 287 15 Crowley P, Chalmers I, Keirse M JNC. The effect of corticosteroid administration before preterm delivery: an overview of the evidence from controlled trials. Brit J Obstet Gynaec. 1990; 97 11-25 16 Fausett M B, Esplin M S. et al . Indomethacin therapy for preterm labor prolongs gestation and is not associated with increased neonatal complications in infants delivered prior to 32 weeks. Am J Obstet Gynecol. 2000; 182 S48 17 Ferguson J E, Hensleigh P A, Kredenster D. Adjunctive use of magnesium sulfate with ritodrine for preterm labor tocolysis. Amer J Obstet Gynec. 1984; 163 767-772 18 Ferguson J E, Dyson D C, Holbrook R H, Schutz T, Stevenson D K. Cardiovascular and metabolic effects associated with nifedipine and ritodrine tocolysis. Amer J Obstet Gynec. 1989; 161 788-795 19 Fuchs A R, Vangsted A, Ivanisevic M, Demarest K. Oxytocin antagonist (dTVT) and oxytocin receptors in myometrium and decidua. Am J Perinat. 1989; 6 205-208 20 Garcia-Velasco J A, Gonzalez G A. A prospektive randomized trial of Nefidipine vs. Ritodrine in threatened preterm labor. Int J Gynaecol Obstet. 1998; 61 239-244 21 Glock J L, Morales W J. Efficacy and safety of nifedipine versus magnesium sulfate in the management of preterm labor: a randomized study. Amer J Obstet Gynec. 1993; 169 960-964 22 Goldenberg R L, Nelson K G, Davis R O, Koski J. Delay in delivery: influence of gestational age and the duration of delay on perinatal outcome. Obstet and Gynec. 1984; 64 480-484 23 Goodwin T M, Millar L, North L. et al . The pharmacokinetics of the oxytocin antagonist atosiban in pregnant women with preterm uterine contractions. Am J Obstet Gynecoll. 1995; 173 913-917 24 Groome L J, Goldenberg R L, Cliver S P, Davis R O, Copper R L. Neonatal periventricular-intraventricular hemorrhage after maternal beta-sympathomimetic tocolysis. The March of Dimes Multicenter Study Group. Amer J Obstet Gynec. 1992; 167 873-879 25 Grospietsch G. Wirkungen bzw. Nebenwirkungen der betamimetischen tokolytischen Therapie bei Mutter und Kind. Spätling L, Fallenstein F Bolustokolyse in Theorie und Praxis. Darmstadt; Steinkopff 1993: 143-163 26 Grospietsch G. Tokolyse mit Atosiban. Gynäkol Prax. 2002; 26 239-246 27 Helleberg L. Clinical pharmacokinetics of indomethacin. Clin Pharmacokinet. 1981; 6 245-258 28 Hickok D E, Hollenbach K A, Reilley S F, Nyberg D A. The association between decreased amniotic fluid volume and treatment with non-steroidal antiinflammatory agents for preterm labor. Amer J Obstet Gynec. 1989; 160 1525-1531 29 Huhta J C, Moise K J, Fisher D J, Sharif D S, Wasserstrum N, Martin C. Detection and quantitation of contraction of the fetal ductus arteriosus by doppler echocardiography. Circulation. 1987; 75 406-412 30 Husslein P, Egarter C. Über die Ursachen des Wehenbeginns beim Menschen. Z Geburtsh Perinat. 1994; 198 163-169 31 Huszar G. Physiology of the myometrium. Creasy RK Maternal Fetal Medicine: Principles and Practice. Philadelphia; Saunders 1989: 141-148 32 Huszar G B, Walsh M P. Relationship between myometrial and cervical functions in pregnancy and labor. Semin Perinat. 1991; 15 97-117 33 Jaspers V, hasenburg A, Abdallah A, Spätling L. Durchführung der Tokolyse heute - Ergebnisse einer Umfrage. Spätling L, Fallenstein F Bolustokolyse in Theorie und Praxis. Darmstadt; Steinkopff 1993: 121-126 34 Kaltreider D F, Kohl S. Epidemiology of preterm delivery. Clin Obstet Gynec. 1980; 23 17-31 35 King J F, Grant A, Keirse M JNC. Beta-mimetics in preterm labour: an overview of the randomized control trials. Brit J Obstet Gynaec. 1988; 95 211-222 36 Korenbrot C C, Aalto L H, Laros R K. The cost effectiveness of stopping preterm labor with beta-adrenergic treatment. New Engl J Med. 1984; 310 691-696 37 Lamont R F, Dunlop P D, Crowley M L, Levena M I, Elder M G. Comparative mortality of infants transferred in utero or post-neonatally. J Perinat Med. 1983; 11 200-203 38 Lees C, Campbell S, Jauniaux E. et al . Arrest of preterm labour and prolongation of gestation with glyceryl trinitrate, a nitric oxide donor. Lancet. 1994; 343 1325-1326 39 Leveno K J, Cuninngham F G. Beta-adrenergic agents for preterm labor. New Engl J Med. 1992; 327 349-351 40 Maggi M, Fantoni G, Baldi E. et al . Antagonists for the human oxytocin receptor: an in vitro study. J Reprod Fertil. 1994; 101 345-352 41 Mari G, Kirshon B, Moise K J, Lee W, Cotten D B. Doppler assessment of the fetal and utero placental circulation during nifedipine therapy for preterm labor. Amer J Obstet Gynec. 1989; 161 1514-1518 42 Melin P, Trojnar J, Johansson B, Vildhardt H, Åkerlund M. Synthetic antagonists of the myometrial response to vasopressin and oxytocin. J Endocr. 1986; 11 125-131 43 Miller J M, Keane M W, Horger E O. A comparison of magnesium sulfate and terbutaline for the arrest of premature labor: a preliminary report. J Reprod Med. 1982; 27 348-351 44 Mittendorf R, Covert R, Boman J. et al . Is tocolytic magnesium sulphate associated with increased total paediatric mortality?. Lancet. 1997; 350 1491 45 Moise K J, Huta J C, Sharif D S, Qu C N, Kishon B, Wasserstrum N. Indomethacin in the treatment of premature labor: effects on the fetal ductus arteriosus. New Engl J Med. 1988; 319 327-331 46 Moise K J. The effect of advancing gestational age on the frequency of fetal ductal constriction secondary to maternal indomethacin use. Amer J Obstet Gynec. 1993; 168 1350-1353 47 Morales W J, Smith S G, Angel J L, O'Brien W F, Knuppel R A. Efficacy and safety of indomethacin versus ritodrine in the managements of preterm labor: a randomized study. Obstet and Gynec. 1989; 169 97-102 48 Morales W J, Madhav H M. Efficacy and safety of indomethacin compared with magnesiumsulfate in the management of preterm labor: a randomized study. Am J Ostet Gynecol. 1993; 169 97-102 49 Moutquin J M, Sherman D, Cohen H. et al . Double-blind, randomized, controlled trial of atosiban and ritodrine in the treatment of preterm labor: a multicenter effectiveness and safety study. Am J Obstet Gynecol. 2000; 182 1191-1199 50 Niebyl J R, Blake D A, White R D. et al . The inhibition of premature labor with indomethacin. Amer J Obstet Gynec. 1980; 136 1014-1019 51 Oei S G, Oei S K, Brolmann H A. Myocardial infarction during nifedipine therapy for preterm labor. N Engl J Med. 1999; 340 154 52 Papatsonis D N, Kok J H, van Geijn H P, Bleker O P, Ader H J, Dekker G A. Neonatal effects of nifedipine and ritodrine for preterm labor. Obstet Gynecol. 2000; 95 477-481 53 Pryde P G, Besinger R E, Gianopoulos J G, Mittendorf R. Adverse and beneficial effects of tocolytic therapy. Semin Perinatol. 2001; 25 316-340 54 Ragosch V, Ebert A D, Hindertmark S. Die imminente Frühgeburt als Notfall. Gynäkologe. 2001; 34 739-743 55 Read M D, Wellby D E. The use of a calcium antagonist (nifedipine) to suppress preterm labor. Brit J Obstet Gynaec. 1986; 93 933-937 56 Repke J T, Niebyl J R. Role of prostaglandin synthetase inhibitors in the treatment of preterm labor. Semin Reprod Endocr. 1985; 3 259 57 Romero R, Sibai B M, Sanchez-Ramos L. et al . An oxytocin receptor antagonist (atosiban) in the treatment of preterm Labor: a randomized, double-blind, placebo-controlled trial with tocolytic rescue. Am J Obstet Gynecol. 2000; 182 1173-1183 58 Rominger K L. Zur Pharmakokinetik von Partusisten. Jung H, Friedrich E Fenoterol (Partusisten) bei der Behandlung in der Geburtshilfe und Perinatologie. Stuttgart, New York; Thieme 1987: 15-20 59 Roth B. Kurz- und Langzeitwirkungen der Tokolyse auf das Neugeborene. Wolff F Standortbestimmung der Tokolysebehandlung. Darmstadt; Steinkopff 1994: 67-78 60 Ryden G, Andersson R G, Berg G. et al . Binding of four oxytocin analouges to myometrial oxytocin and arginine-vasopressin binding sites in pregnant women. Gynecol Obstet Invest. 1990; 29 6-9 61 Schneider H, Naiem A, Malek A, Hänggi W. Aetiologische Klassifizierung der Frühgeburt und ihre Bedeutung für die Prävention. Geburtsh Frauenheilk. 1994; 54 12-19 62 Schneider H. Pharmacological intervention in preterm labour. Res Clin Forums. 1994; 16 59-83 63 Schneider H, Berger-Menz E, Hänggi W. Besonderheiten der Geburtsleitung bei der kleinen Frühgeburt. Arch Gynec. 1995; 257 462-471 64 Sibai B M, Villar M A, Bray E. Magnesium supplementation during pregnancy: a double-blind randomized controlled clinical trial. Amer J Obstet Gynec. 1989; 161 115-119 65 Spätling L. Orale Magnesium-Zusatztherapie bei vorzeitiger Wehentätigkeit. Geburtsh Frauenheilk. 1981; 41 101-102 66 Spätling L. Die Frühgeburt vor der 34. Schwangerschaftswoche: Häufigkeit, Ursachen und Früherkennung. Gynäkologe. 1987; 20 4-13 67 Spätling L, Spätling G. Magnesium supplementation during pregnancy: a double blind study. Brit J Obstet Gynaec. 1988; 95 120-125 68 Spätling L, Fallenstein F, Schneider H, Dancis J. Bolus tocolysis: treatment of preterm labor with pulsatile administration of beta-adrenergic agonists. Amer J Obstet Gynec. 1989; 160 713-717 69 Steer C M, Petrie R H. A comparision of magnesium sulfate and alcohol for the prevention of premature labor. Amer J Obstet Gynec. 1977; 129 1-4 70 Teichmann A T. Vorkommen und psychosoziale Bedingungen der vorzeitigen Wehentätigkeit. Gynäkologe. 1987; 20 14-19 71 The Worldwide Atosiban versus Beta-agonists Study Group . Effectiveness and safety of the oxytocin antagonist atosiban versus beta-adrenergic agonists in the treatment of preterm labour. The Worldwide Atosiban versus Beta-agonists Study Group. BJG. 2001; 108 133-142 72 Thronton S, Gillespie J I, Anson L C. et al . The effect of the oxytocin antagonists CAP 476 and F 327 on calcium mobilisation in single cultured human myometrial cells. Br J Obstet Gynaecol. 1993; 100 581-586 73 Tsatsaris V, Papatsonis D, Goffinet F, Dekker G, Carbonne B. Tokolysis with nifedipin or betaadrenergic agonists: a metaanalysis. Obstet Gynecol. 2002; 99 518-519 74 Valenzuela G J, Craig J, Bernhardt M D. et al . Placental passage of the oxytocin antagonist atosiban. Am J Obstet Gynecol. 1995; 172 1304-1306 75 Valenzuela G J, Sanchez-Ramos L, Romero R. et al . Maintenance treatment of preterm labor with the oxytocin antagonist atosiban. Am J Obstet Gynecol. 2000; 182 1184-1190 76 van den Vejver J B, Moise K J. Prostaglandin synthetase inhibitors in pregnancy. Obstet Gynec Surv. 1993; 48 493-502 77 Weintraub Z, Solovechick M, Reichman B. et al . Effect of maternal tocolysis on the incidence of severe periventricular/intraventricular haemorrhage in very low birthweight infants. Arch Dis Child Fetal Neonatal Ed. 2001; 85 F13-17 78 Wilkins I A, Lynch L, Mehalek K E, Berkowitz G S, Berkowitz R L. Efficacy and side effects of magnesium sulfate and ritodrine as tocolytic agents. Amer J Obstet Gynec. 1988; 159 685-689 79 Ziegler A. Wirksamkeit von Nitratpflastern bei vorzeitiger Wehentätigkeit. Gynäk Prax. 1996; 20 25-26