Endogene Steuerung der Ovarialfunktion - Teil 1

Grundlagen

Die physiologische Funktion des Ovars, gekennzeichnet durch die Bereitstellung der Eizellen sowie Produktion der Sexualhormone Östradiol und Progesteron, bildet die Grundlage weiblicher Fertilität. Beide Prozesse sind eng miteinander verwoben und während der reproduktiven Jahre in optimaler Weise aufeinander abgestimmt. Der Menstruationszyklus - auf ovarieller Ebene unterteilt in Follikelreifung, Ovulation und Gelbkörperphase - ist Ausdruck dieses mit großer Regelmäßigkeit ablaufenden Geschehens. Das Verständnis der Steuerung dieses Prozesses ist Grundlage für die Diagnostik eventuell auftretender Störungen.

Literatur

• 1 Suh C S, Sonntag B, Erickson G F. Ovarian life cycle: a contemporary view.  Rev Endocr Metab Disord. 2002;  3 5-12
• 2 Ohno S, Smith J B. Role of fetal follicular cells in meiosis of mammalian oocytes.  Cytogenetics. 1964;  3 324-333
• 3 Vainio S, Heikkila M, Kispert A, Chin N, McMahon A P. Female development in mammals is regulated by Wnt-4 signaling.  Nature. 1999;  397 405-409
• 4 Durlinger A L, Gruijters M J, Kramer P, Karels B, Ingraham H A, Nachtigal M W, Uilenbroek J T, Grootegoed J A, Themmen A P. Anti-Mullerian hormone inhibits initiation of primordial follicle growth in the mouse ovary.  Endocrinology. 2002;  143 1076-1084
• 5 Fortune J E, Cushman R A, Wahl C M, Kito S. The primordial to primary follicle transition.  Mol Cell Endocrinol. 2000;  163 53-60
• 6 Yoshida H. 6 . Stepwise requirement of c-kit tyrosine kinase in mouse ovarian follicle development.  Dev Biol. 1997;  184 122-137
• 7 Dong J, Albertini D F, Nishimori K, Kumar T R L N, Matzuk M. Growth differentiation factor-9 is required during early ovarian folliculogenesis.  Nature. 1996;  383 531-535
• 8 Kumar T R, Wang Y, Lu N, Matzuk M M. Follicle stimulating hormone is required for ovarian follicle maturation but not male fertility.  Nat Genet. 1997;  15 201-204
• 9 Frisch R E, McArthur J W. Menstrual cycles: fatness as a determinant of minimum weight for height necessary for their maintenance or onset.  Science. 1974;  185 949-951
• 10 de Muinich Keizer S M, Mul D. Trends in pubertal development in Europe.  Hum Reprod Update. 2001;  7 287-291
• 11 Catzeflis C, Pierroz D D, Rohner-Jeanrenaud F, Rivier J E, Sizonenko P C, Aubert M L. Neuropeptide Y administered chronically into the lateral ventricle profoundly inhibits both the gonadotropic and the somatotropic axis in intact adult female rats.  Endocrinology. 1993;  132 224-234
• 12 Campfield L A, Smith F J, Guisez Y, Devos R, Burn P. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks.  Science. 1995;  269 546-549
• 13 Richardson S J, Senikas V, Nelson J F. Follicular depletion during the menopausal transition: evidence for accelerated loss and ultimate exhaustion.  J Clin Endocrinol Metab. 1987;  65 1231-1237
• 14 Knobil E. The neuroendocrine control of the menstrual cycle.  Recent Prog Horm Res. 1980;  36 53-88
• 15 Filicori M, Santoro N, Merriam G R, Crowley Jr W F. Characterization of the physiological pattern of episodic gonadotropin secretion throughout the human menstrual cycle.  J Clin Endocrinol Metab. 1986;  62 1136-1144
• 16 Conn P M, Crowley Jr W F. Gonadotropin-releasing hormone and its analogs.  Annu Rev Med. 1994;  45 391-405
• 17 Gougeon A. Regulation of ovarian follicular development in primates: facts and hypotheses.  Endocr Rev. 1996;  17 121-155
• 18 Falck B. Site of production of oestrogen in rat ovary as studied in micro-transplants.  Acta Physiol Scand. 1959;  47 1-101
• 19 Tilly J L, LaPolt P S, Hsueh A J. Hormonal regulation of follicle-stimulating hormone receptor messenger ribonucleic acid levels in cultured rat granulosa cells.  Endocrinology. 1992;  130 1296-1302
• 20 Erickson G F, Wang C, Hsueh A J. FSH induction of functional LH receptors in granulosa cells cultured in a chemically defined medium.  Nature. 1979;  279 336-338
• 21 Mayerhofer A, Dimitrijevic N, Kunz L. The expression and biological role of the non-neuronal cholinergic system in the ovary.  Life Sci. 2003;  72 2039-2045
• 22 Liu J P, Baker J, Perkins A S, Robertson E J, Efstratiadis A. Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1 r).  Cell. 1993;  75 59-72
• 23 Erickson G F, Garzo V G, Magoffin D A. Insulin-like growth factor-I regulates aromatase activity in human granulosa and granulosa luteal cells.  J Clin Endocrinol Metab. 1989;  69 716-724
• 24 Nakatani A, Shimasaki S, Erickson G F, Ling N. Tissue-specific expression of four insulin-like growth factor-binding proteins (1, 2, 3, and 4) in the rat ovary.  Endocrinology. 1991;  129 1521-1529
• 25 Cataldo N A, Giudice L C. Insulin-like growth factor binding protein profiles in human ovarian follicular fluid correlate with follicular functional status.  J Clin Endocrinol Metab. 1992;  74 821-829
• 26 Hourvitz A, Widger A E, Filho F L, Chang R J, Adashi E Y, Erickson G F. Pregnancy-associated plasma protein-A gene expression in human ovaries is restricted to healthy follicles and corpora lutea.  J Clin Endocrinol Metab. 2000;  85 4916-4920
• 27 Rivera G M, Fortune J E. Proteolysis of insulin-like growth factor binding proteins -4 and - 5 in bovine follicular fluid: implications for ovarian follicular selection and dominance.  Endocrinology. 2003;  144 2977-2987
• 28 Erickson G F, Shimasaki S. The role of the oocyte in folliculogenesis.  Trends Endocrinol Metab. 2000;  11 193-198
• 29 Channing C P. Influences of the in vivo and in vitro hormonal environment upon luteinization of granulosa cells in tissue culture.  Recent Prog Horm Res. 1970;  26 589-622
• 30 Vitt U A, Hayashi M, Klein C, Hsueh A JW. Growth differentiation factor-9 stimulates proliferation but suppresses the follicle-stimulating hormone-induced differentiation of cultured granulosa cells from small antral and preovulatory rat follicles.  Biol Reprod. 2000;  62 370-377
• 31 Otsuka F, Yao Z, Lee T, Yamamoto S, Erickson G F, Shimasaki S. Bone morphogenetic protein-15. Identification of target cells and biological functions.  J Biol Chem. 2000;  275 39523-39528
• 32 Otsuka F, Yamamoto S, Erickson G F, Shimasaki S. Bone morphogenetic protein-15 inhibits follicle-stimulating hormone (FSH) action by suppressing FSH receptor expression.  J Biol Chem. 2001;  276 11387-11392