Strategies for the Preparation of (1-Acetyloxyethylidene)-1,1-bisphosphonic Acid Derivatives

Petri A. Turhanen; Jouko J. Vepsäläinen

doi:10.1055/s-2004-822345

SHORTPAPER

Strategies for the Preparation of (1-Acetyloxyethylidene)-1,1-bisphosphonic Acid Derivatives

Petri A. Turhanen*, Jouko J. Vepsäläinen
University of Kuopio, Department of Chemistry, P.O. Box 1627, 70211 Kuopio, Finland
Fax: +358(17)163259; e-Mail: Petri.Turhanen@uku.fi;

Abstract

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Abstract

The novel strategies for the synthesis of acetylated etidronic acid derivatives were investigated. (1-Acetyloxyethylidene)-1,1-bisphosphonic acid and its P,P′-dimethyl, trimethyl and tetramethyl esters were prepared in high 81-100% yields.

Key words

bisphosphonate - etidronate - partial esters - synthesis - prodrug

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References

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